All Stories

  1. Improved Immune Responses and Tuberculosis Protection by Aerosol Vaccination with recombinant BCG expressing ESX-1 from Mycobacterium marinum

    Article • September 2025, Cold Spring Harbor Laboratory Press

    Dr Fadel SAYES

  2. Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection

    Article • September 2025, Cold Spring Harbor Laboratory Press

    Dr Fadel SAYES

  3. Evaluation of the role of whiB6 and kdpDE in the dominant multidrug-resistant clone Mycobacterium tuberculosis B0/W148

    Article • Microbiology Spectrum, July 2025, ASM Journals

    Dr Fadel SAYES

  4. Speeding up drug susceptibility testing in Mycobacterium tuberculosis using RNA biomarkers

    Article • EBioMedicine, March 2025, Elsevier

    Dr Fadel SAYES

  5. Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillus

    Article • PLoS Pathogens, August 2024, PLOS

    Dr Fadel SAYES

  6. Genomic and phenotypic characterization of Mycobacterium tuberculosis’ closest-related non-tuberculous mycobacteria

    Article • Microbiology Spectrum, June 2024, ASM Journals

    Wafa FRIGUI, Dr Fadel SAYES

  7. Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli

    Article • PLoS Pathogens, July 2023, PLOS

    Wafa FRIGUI, Dr Fadel SAYES

  8. The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy

    Article • Molecular Therapy — Nucleic Acids, March 2022, Elsevier

    Dr Fadel SAYES

  9. Breaching the phagosome, the case of the tuberculosis agent

    Article • Cellular Microbiology, May 2021, Hindawi Publishing Corporation

    Dr Fadel SAYES

  10. Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors

    Article • Frontiers in Cellular and Infection Microbiology, August 2020, Frontiers

    Dr Fadel SAYES

  11. Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential

    Article • EBioMedicine, May 2020, Elsevier

    Dr Fadel SAYES

  12. TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages

    Article • Nature Communications, February 2020, Springer Science + Business Media

    Dr Fadel SAYES

  13. Mycobacterial virulence: impact on immunogenicity and vaccine research

    Article • F1000Research, November 2019, Faculty of 1000, Ltd.

    Dr Fadel SAYES, Wafa FRIGUI

  14. Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity

    Article • Genome Biology and Evolution, July 2018, Oxford University Press (OUP)

    Dr Fadel SAYES

  15. RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

    Article • PLoS Pathogens, June 2018, PLOS

    Dr Fadel SAYES, Wafa FRIGUI

  16. Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors

    Article • Cell Reports, April 2018, Elsevier

    Dr Fadel SAYES, Wafa FRIGUI

  17. Basophil activation through TLR2 and TLR4 signaling pathways

    Article • AIMS Allergy and Immunology, January 2018, American Institute of Mathematical Sciences (AIMS)

    Dr Fadel SAYES

  18. Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

    Article • Cell Reports, March 2017, Elsevier

    Dr Fadel SAYES, Wafa FRIGUI

  19. ESX-1 and phthiocerol dimycocerosates ofMycobacterium tuberculosisact in concert to cause phagosomal rupture and host cell apoptosis

    Article • Cellular Microbiology, February 2017, Wiley

    Dr Fadel SAYES

  20. Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis

    Article • Mucosal Immunology, February 2017, Springer Science + Business Media

    Dr Fadel SAYES

  21. ESX secretion systems: mycobacterial evolution to counter host immunity

    Article • Nature Reviews Microbiology, September 2016, Springer Science + Business Media

    Dr Fadel SAYES

  22. CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

    Article • PLoS Pathogens, July 2016, PLOS

    Dr Fadel SAYES, Wafa FRIGUI

  23. Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo

    Article • PLoS Pathogens, February 2015, PLOS

    Dr Fadel SAYES

  24. Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

    Article • Nature Genetics, January 2013, Springer Science + Business Media

    Dr Sylvain Brisse, Professor Julian Parkhill, Dr Fadel SAYES, Wafa FRIGUI

  25. Strong Immunogenicity and Cross-Reactivity of Mycobacterium tuberculosis ESX-5 Type VII Secretion -Encoded PE-PPE Proteins Predicts Vaccine Potential

    Article • Cell Host & Microbe, April 2012, Elsevier

    Dr Fadel SAYES

  26. Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation

    Article • Molecular Microbiology, February 2012, Wiley

    Dr Fadel SAYES, Wafa FRIGUI