All Stories

  1. Improved immune responses and tuberculosis protection by aerosol vaccination with recombinant BCG expressing ESX-1 from Mycobacterium marinum

    Article • PLoS Pathogens, February 2026, PLOS

    Wafa FRIGUI

  2. Evaluation of the role of whiB6 and kdpDE in the dominant multidrug-resistant clone Mycobacterium tuberculosis B0/W148

    Article • Microbiology Spectrum, July 2025, ASM Journals

    Dr Fadel SAYES, Wafa FRIGUI

  3. Speeding up drug susceptibility testing in Mycobacterium tuberculosis using RNA biomarkers

    Article • EBioMedicine, March 2025, Elsevier

    Dr Fadel SAYES, Wafa FRIGUI

  4. Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillus

    Article • PLoS Pathogens, August 2024, PLOS

    Dr Fadel SAYES, Wafa FRIGUI

  5. Genomic and phenotypic characterization of Mycobacterium tuberculosis’ closest-related non-tuberculous mycobacteria

    Article • Microbiology Spectrum, June 2024, ASM Journals

    Wafa FRIGUI, Dr Fadel SAYES

  6. A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection

    Article • PLoS Biology, April 2024, PLOS

    Wafa FRIGUI

  7. Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli

    Article • PLoS Pathogens, July 2023, PLOS

    Wafa FRIGUI, Dr Fadel SAYES

  8. De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

    Article • eLife, December 2021, eLife

    Wafa FRIGUI

  9. Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli

    Article • Nature Microbiology, July 2021, Springer Science + Business Media

    Wafa FRIGUI

  10. ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains

    Article • mBio, June 2021, ASM Journals

    Wafa FRIGUI

  11. Phenotypic and genomic hallmarks of a novel, potentially pathogenic rapidly growing Mycobacterium species related to the Mycobacterium fortuitum complex

    Article • Scientific Reports, June 2021, Springer Science + Business Media

    Wafa FRIGUI

  12. Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts

    Article • Microbial Genomics, February 2021, Society for General Microbiology

    Wafa FRIGUI

  13. Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential

    Article • EBioMedicine, May 2020, Elsevier

    Dr Fadel SAYES, Wafa FRIGUI

  14. Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis

    Article • Scientific Reports, February 2020, Springer Science + Business Media

    Wafa FRIGUI

  15. TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages

    Article • Nature Communications, February 2020, Springer Science + Business Media

    Dr Fadel SAYES, Wafa FRIGUI

  16. Mycobacterial virulence: impact on immunogenicity and vaccine research

    Article • F1000Research, November 2019, Faculty of 1000, Ltd.

    Dr Fadel SAYES, Wafa FRIGUI

  17. RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

    Article • PLoS Pathogens, June 2018, PLOS

    Dr Fadel SAYES, Wafa FRIGUI

  18. Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors

    Article • Cell Reports, April 2018, Elsevier

    Dr Fadel SAYES, Wafa FRIGUI

  19. PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis

    Article • PLoS Pathogens, May 2017, PLOS

    Wafa FRIGUI

  20. Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

    Article • Cell Reports, March 2017, Elsevier

    Dr Fadel SAYES, Wafa FRIGUI

  21. CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

    Article • PLoS Pathogens, July 2016, PLOS

    Dr Fadel SAYES, Wafa FRIGUI

  22. pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence

    Article • Nature Microbiology, January 2016, Springer Science + Business Media

    Wafa FRIGUI

  23. The changes in mycolic acid structures caused byhadCmutation have a dramatic effect on the virulence ofMycobacterium tuberculosis

    Article • Molecular Microbiology, November 2015, Wiley

    Wafa FRIGUI

  24. Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis

    Article • Scientific Reports, November 2015, Nature

    Dr Jean-Louis Herrmann, Wafa FRIGUI

  25. ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection

    Article • Tuberculosis, June 2015, Elsevier

    Wafa FRIGUI

  26. Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system

    Article • Vaccine, May 2015, Elsevier

    Wafa FRIGUI

  27. A Specific Polymorphism in Mycobacterium tuberculosis H37Rv Causes Differential ESAT-6 Expression and Identifies WhiB6 as a Novel ESX-1 Component

    Article • Infection and Immunity, June 2014, ASM Journals

    Professor Carlos Martin, Wafa FRIGUI

  28. Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

    Article • Nature Genetics, January 2013, Springer Science + Business Media

    Dr Sylvain Brisse, Professor Julian Parkhill, Dr Fadel SAYES, Wafa FRIGUI

  29. Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation

    Article • Molecular Microbiology, February 2012, Wiley

    Dr Fadel SAYES, Wafa FRIGUI

  30. ESAT-6 Secretion-Independent Impact of ESX-1 Genes espF and espG1 on Virulence of Mycobacterium tuberculosis

    Article • The Journal of Infectious Diseases, April 2011, Oxford University Press (OUP)

    Wafa FRIGUI

  31. Control of M. tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP

    Article • PLoS Pathogens, January 2008, PLOS

    Professor Carlos Martin, Wafa FRIGUI

  32. Genome plasticity of BCG and impact on vaccine efficacy

    Article • Proceedings of the National Academy of Sciences, March 2007, Proceedings of the National Academy of Sciences

    Wafa FRIGUI

  33. Early trafficking events of Mycobacterium ulcerans within Naucoris cimicoides

    Article • Cellular Microbiology, February 2007, Wiley

    Wafa FRIGUI

  34. Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer

    Article • Genome Research, January 2007, Cold Spring Harbor Laboratory Press

    Wafa FRIGUI

  35. Article • Arthritis Research & Therapy, January 2006, Springer Science + Business Media

    Wafa FRIGUI

  36. Common Evolutionary Origin for the Unstable Virulence Plasmid pMUM Found in Geographically Diverse Strains of Mycobacterium ulcerans

    Article • Journal of Bacteriology, March 2005, ASM Journals

    Wafa FRIGUI

  37. Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans

    Article • Proceedings of the National Academy of Sciences, January 2004, Proceedings of the National Academy of Sciences

    Wafa FRIGUI