All Stories

  1. Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli

    Article • PLoS Pathogens, July 2023, PLOS

    Wafa FRIGUI

  2. De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

    Article • eLife, December 2021, eLife

    Wafa FRIGUI

  3. Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli

    Article • Nature Microbiology, July 2021, Springer Science + Business Media

    Wafa FRIGUI

  4. ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains

    Article • mBio, June 2021, ASM Journals

    Wafa FRIGUI

  5. Phenotypic and genomic hallmarks of a novel, potentially pathogenic rapidly growing Mycobacterium species related to the Mycobacterium fortuitum complex

    Article • Scientific Reports, June 2021, Springer Science + Business Media

    Wafa FRIGUI

  6. Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts

    Article • Microbial Genomics, February 2021, Society for General Microbiology

    Wafa FRIGUI

  7. Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis

    Article • Scientific Reports, February 2020, Springer Science + Business Media

    Wafa FRIGUI

  8. Mycobacterial virulence: impact on immunogenicity and vaccine research

    Article • F1000Research, November 2019, Faculty of 1000, Ltd.

    Dr Fadel SAYES, Wafa FRIGUI

  9. RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

    Article • PLoS Pathogens, June 2018, PLOS

    Dr Fadel SAYES, Wafa FRIGUI

  10. Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors

    Article • Cell Reports, April 2018, Elsevier

    Dr Fadel SAYES, Wafa FRIGUI

  11. PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis

    Article • PLoS Pathogens, May 2017, PLOS

    Wafa FRIGUI

  12. Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

    Article • Cell Reports, March 2017, Elsevier

    Dr Fadel SAYES, Wafa FRIGUI

  13. CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

    Article • PLoS Pathogens, July 2016, PLOS

    Dr Fadel SAYES, Wafa FRIGUI

  14. pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence

    Article • Nature Microbiology, January 2016, Springer Science + Business Media

    Wafa FRIGUI

  15. The changes in mycolic acid structures caused byhadCmutation have a dramatic effect on the virulence ofMycobacterium tuberculosis

    Article • Molecular Microbiology, November 2015, Wiley

    Wafa FRIGUI

  16. Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis

    Article • Scientific Reports, November 2015, Nature

    Dr Jean-Louis Herrmann, Wafa FRIGUI

  17. ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection

    Article • Tuberculosis, June 2015, Elsevier

    Wafa FRIGUI

  18. Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system

    Article • Vaccine, May 2015, Elsevier

    Wafa FRIGUI

  19. A Specific Polymorphism in Mycobacterium tuberculosis H37Rv Causes Differential ESAT-6 Expression and Identifies WhiB6 as a Novel ESX-1 Component

    Article • Infection and Immunity, June 2014, ASM Journals

    Professor Carlos Martin, Wafa FRIGUI

  20. Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

    Article • Nature Genetics, January 2013, Springer Science + Business Media

    Dr Sylvain Brisse, Professor Julian Parkhill, Dr Fadel SAYES, Wafa FRIGUI

  21. Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation

    Article • Molecular Microbiology, February 2012, Wiley

    Dr Fadel SAYES, Wafa FRIGUI

  22. ESAT-6 Secretion-Independent Impact of ESX-1 Genes espF and espG1 on Virulence of Mycobacterium tuberculosis

    Article • The Journal of Infectious Diseases, April 2011, Oxford University Press (OUP)

    Wafa FRIGUI

  23. Control of M. tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP

    Article • PLoS Pathogens, January 2008, PLOS

    Professor Carlos Martin, Wafa FRIGUI

  24. Genome plasticity of BCG and impact on vaccine efficacy

    Article • Proceedings of the National Academy of Sciences, March 2007, Proceedings of the National Academy of Sciences

    Wafa FRIGUI

  25. Early trafficking events of Mycobacterium ulcerans within Naucoris cimicoides

    Article • Cellular Microbiology, February 2007, Wiley

    Wafa FRIGUI

  26. Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer

    Article • Genome Research, January 2007, Cold Spring Harbor Laboratory Press

    Wafa FRIGUI

  27. Article • Arthritis Research & Therapy, January 2006, Springer Science + Business Media

    Wafa FRIGUI

  28. Common Evolutionary Origin for the Unstable Virulence Plasmid pMUM Found in Geographically Diverse Strains of Mycobacterium ulcerans

    Article • Journal of Bacteriology, March 2005, ASM Journals

    Wafa FRIGUI

  29. Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans

    Article • Proceedings of the National Academy of Sciences, January 2004, Proceedings of the National Academy of Sciences

    Wafa FRIGUI