All Stories

  1. “In Litero” Screening: Retrospective Evaluation of Clinical Evidence to Establish a Reference List of Human Chemical Respiratory Sensitizers

    Article • Frontiers in Toxicology, July 2022, Frontiers

    Dr. Erwin L J Roggen

  2. Mechanistic data linked to Alzheimer’s disease.

    Article • Journal of Alzheimer s Disease Reports, June 2022, IOS Press

    Maria Tsamou, Dr. Erwin L J Roggen

  3. The impact of chemicals on late-onset Alzheimer's can be assessed using specific biomarkers.

    Article • Journal of Alzheimer s Disease, April 2022, IOS Press

    Dr. Erwin L J Roggen, Maria Tsamou

  4. iPSC-derived neurons as in vitro models to identify Alzheimer's and AD-related molecular mechanisms.

    Article • Toxicology Letters, March 2022, Elsevier

    Dr. Erwin L J Roggen

  5. Moving towards a probabilistic risk assessment approach without animal experimentation

    Article • Toxicology, June 2021, Elsevier

    Dr. Erwin L J Roggen

  6. Environmental neurotoxicants push the aging brain towards late-onset Alzheimer's disease.

    Article • Journal of Alzheimer s Disease, May 2021, IOS Press

    Dr. Erwin L J Roggen

  7. Skin Sensitization Tests: The LLNA and the RhE IL-18 Potency

    Article • January 2021, Springer Science + Business Media

    Dr. Erwin L J Roggen

  8. An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxic effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals

    Article • Toxicology in Vitro, August 2020, Elsevier

    Dr. Erwin L J Roggen

  9. COST Action ‘ImpARAS’: what have we learnt to improve food allergy risk assessment. A summary of a 4 year networking consortium

    Article • Clinical and Translational Allergy, May 2020, Wiley

    Dr. Erwin L J Roggen

  10. In vitro RHE skin sensitisation assays: Applicability to challenging substances

    Article • Regulatory Toxicology and Pharmacology, November 2019, Elsevier

    Dr. Erwin L J Roggen

  11. Validation of the GARD™skin Assay for Assessment of Chemical Skin Sensitizers: Ring Trial Results of Predictive Performance and Reproducibility

    Article • Toxicological Sciences, May 2019, Oxford University Press (OUP)

    Dr. Erwin L J Roggen

  12. Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies

    Article • Trends in Food Science & Technology, March 2019, Elsevier

    Dr. Erwin L J Roggen

  13. One science-driven approach for the regulatory implementation of alternative methods: A multi-sector perspective

    Article • Regulatory Toxicology and Pharmacology, November 2018, Elsevier

    Dr. Erwin L J Roggen

  14. Evaluation of 3D skin model-based assays using difficult to test substances: an EPAA multi-sector project

    Article • Toxicology Letters, October 2018, Elsevier

    Dr. Erwin L J Roggen

  15. The validation of GARDskin

    Article • Toxicology Letters, October 2018, Elsevier

    Dr. Erwin L J Roggen

  16. Development of an In Vitro Method to Estimate the Sensitization Induction Level of Contact Allergens

    Article • Current Protocols in Toxicology, February 2018, Wiley

    Dr. Erwin L J Roggen

  17. An alternative biomarker-based approach for the prediction of proteins known to sensitize the respiratory tract

    Article • Toxicology in Vitro, February 2018, Elsevier

    Dr. Erwin L J Roggen

  18. Activation of Stored Messenger Ribonucleoproteins: Identification and Function of the Proteins Associated with Nonpolysomal Poly(A)-Containing Messenger Ribonucleoproteins of Cryptobiotic Gastrulae of Artemia sp.

    Article • January 2018, Taylor & Francis

    Dr. Erwin L J Roggen

  19. Assessment of metal sensitizer potency with the reconstructed human epidermis IL-18 assay

    Article • Toxicology, January 2018, Elsevier

    Dr. Erwin L J Roggen

  20. An adverse outcome pathway for respiratory sensitization by chemicals: The way forward?

    Article • Toxicology Letters, October 2017, Elsevier

    Dr Grace Patlewicz, Dr. Erwin L J Roggen

  21. Advances in the development of in vitro airway models as innovative tools to identify chemical respiratory sensitizers

    Article • Toxicology Letters, October 2017, Elsevier

    Dr. Erwin L J Roggen

  22. Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

    Article • Clinical and Translational Allergy, May 2017, Wiley

    Dr. Erwin L J Roggen

  23. Development of an in vitro method to estimate the sensitization induction level of contact allergens

    Article • Toxicology Letters, April 2017, Elsevier

    Dr. Erwin L J Roggen

  24. Developing a framework for assessing chemical respiratory sensitization: A workshop report

    Article • Regulatory Toxicology and Pharmacology, October 2016, Elsevier

    Dr. Erwin L J Roggen

  25. Preliminary performance data of the RHE/IL-18 assay performed on SkinEthic™RHE for the identification of contact sensitizers

    Article • International Journal of Cosmetic Science, August 2016, Wiley

    Dr. Erwin L J Roggen

  26. Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology

    Article • ALTEX, January 2015, ALTEX Edition

    Dr. Erwin L J Roggen

  27. Treatment of both native and deamidated gluten peptides with an endo-peptidase from Aspergillus niger prevents stimulation of gut-derived gluten-reactive T cells from either children or adults with celiac disease

    Article • Clinical Immunology, August 2014, Elsevier

    Dr. Erwin L J Roggen

  28. IgE versus IgG4 epitopes of the peanut allergen Ara h 1 in patients with severe allergy

    Article • Molecular Immunology, April 2014, Elsevier

    Dr. Erwin L J Roggen

  29. In VitroApproaches for Detection of Chemical Sensitization

    Article • Basic & Clinical Pharmacology & Toxicology, February 2014, Wiley

    Dr. Erwin L J Roggen

  30. Proceedings of the 17th ESTIV congress 2012

    Article • Toxicology in Vitro, February 2014, Elsevier

    Dr. Erwin L J Roggen

  31. State of the art on alternative methods to animal testing from an industrial point of view: ready for regulation?

    Article • ALTEX, January 2014, ALTEX Edition

    Dr. Erwin L J Roggen

  32. Allergic sensitization: screening methods

    Article • Clinical and Translational Allergy, January 2014, Wiley

    Dr. Erwin L J Roggen

  33. International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive capacity

    Article • ALTEX, January 2014, ALTEX Edition

    Dr. Erwin L J Roggen

  34. An epidermal equivalent assay for identification and ranking potency of contact sensitizers

    Article • Toxicology and Applied Pharmacology, October 2013, Elsevier

    Dr. Erwin L J Roggen

  35. Sens-it-iv: A European Union project to develop novel tools for the identification of skin and respiratory sensitizers

    Article • Toxicology in Vitro, April 2013, Elsevier

    Dr. Erwin L J Roggen

  36. Application of the acquired knowledge and implementation of the Sens-it-iv toolbox for identification and classification of skin and respiratory sensitizers

    Article • Toxicology in Vitro, April 2013, Elsevier

    Dr. Erwin L J Roggen

  37. Potential of in vitro reconstituted 3D human airway epithelia (MucilAir™) to assess respiratory sensitizers

    Article • Toxicology in Vitro, April 2013, Elsevier

    Dr. Erwin L J Roggen

  38. Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency

    Article • Toxicology in Vitro, April 2013, Elsevier

    Dr. Erwin L J Roggen

  39. Advanced tests for skin and respiratory sensitization assessment

    Article • ALTEX, January 2013, ALTEX Edition

    Dr. Erwin L J Roggen

  40. IgE epitopes of intact and digested Ara h 1: A comparative study in humans and rats

    Article • Molecular Immunology, July 2012, Elsevier

    Dr. Erwin L J Roggen

  41. Implementation challenges for designing Integrated In Vitro Testing Strategies (ITS) aiming at reducing and replacing animal experimentation

    Article • Toxicology in Vitro, April 2012, Elsevier

    Dr. Erwin L J Roggen

  42. A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing

    Article • ALTEX, January 2012, ALTEX Edition

    Dr. Erwin L J Roggen

  43. Respiratory sensitization: Advances in assessing the risk of respiratory inflammation and irritation

    Article • Toxicology in Vitro, October 2011, Elsevier

    Dr. Erwin L J Roggen

  44. Toxicology in the 21st century – Working our way towards a visionary reality

    Article • Toxicology in Vitro, June 2011, Elsevier

    Dr. Erwin L J Roggen

  45. In vitro Toxicity Testing in the Twenty-First Century

    Article • Frontiers in Pharmacology, January 2011, Frontiers

    Dr. Erwin L J Roggen

  46. An expert consortium review of the EC-commissioned report “Alternative (Non-Animal) Methods for Cosmetics Testing: Current Status and Future Prospects – 2010”

    Article • ALTEX, January 2011, ALTEX Edition

    Dr. Erwin L J Roggen

  47. Immunotoxicology: Opportunities for Non-animal Test Development

    Article • Alternatives to Laboratory Animals, September 2009, SAGE Publications

    Dr. Erwin L J Roggen

  48. Selection of Chemicals for the Development and Evaluation of In Vitro Methods for Skin Sensitisation Testing

    Article • Alternatives to Laboratory Animals, July 2009, SAGE Publications

    Dr. Erwin L J Roggen

  49. The Development of Novel Approaches to the Identification of Chemical and Protein Respiratory Allergens

    Article • Alternatives to Laboratory Animals, November 2008, SAGE Publications

    Dr. Erwin L J Roggen

  50. The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays

    Article • Mutation Research/Reviews in Mutation Research, September 2008, Elsevier

    Dr. Erwin L J Roggen

  51. B-cell epitope engineering: A matter of recognizing protein features and motives

    Article • Drug Discovery Today Technologies, September 2008, Elsevier

    Dr. Erwin L J Roggen

  52. Management of an Integrated Project (Sens-it-iv) to Develop In Vitro Tests to Assess Sensitisation

    Article • Alternatives to Laboratory Animals, June 2007, SAGE Publications

    Dr. Erwin L J Roggen

  53. Chemical Respiratory Allergy: Opportunities for Hazard Identification and Characterisation

    Article • Alternatives to Laboratory Animals, May 2007, SAGE Publications

    Dr. Erwin L J Roggen

  54. Skin Sensitisation and Epidermal Disposition: The Relevance of Epidermal Disposition for Sensitisation Hazard Identification and Risk Assessment

    Article • Alternatives to Laboratory Animals, March 2007, SAGE Publications

    Dr. Erwin L J Roggen

  55. Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools

    Article • Journal of Molecular Recognition, January 2007, Wiley

    Dr James E Crowe, Prof Gajendra PS Raghava, Dr. Erwin L J Roggen

  56. Respiratory immunotoxicity: An in vitro assessment

    Article • Toxicology in Vitro, December 2006, Elsevier

    Dr. Erwin L J Roggen

  57. Investigation on possible allergenicity of 19 different commercial enzymes used in the food industry

    Article • Food and Chemical Toxicology, November 2006, Elsevier

    Dr. Erwin L J Roggen

  58. Interactions between dendritic cells and epithelial cells in allergic disease

    Article • Toxicology Letters, March 2006, Elsevier

    Dr. Erwin L J Roggen

  59. A novel approach for investigation of specific and cross-reactive IgE epitopes on Bet v 1 and homologous food allergens in individual patients

    Article • Molecular Immunology, February 2006, Elsevier

    Dr. Erwin L J Roggen

  60. Recent Developments with B-Cell Epitope Identification for Predictive Studies

    Article • Journal of Immunotoxicology, January 2006, Taylor & Francis

    Dr. Erwin L J Roggen

  61. Individuals with occupational allergy to detergent enzymes display a differential transcriptional regulation and cellular immune response

    Article • Clinical & Experimental Allergy, February 2005, Wiley

    Dr. Erwin L J Roggen

  62. Vaccination for birch pollen allergy: comparison of the affinities of specific immunoglobulins E, G1 and G4 measured by surface plasmon resonance

    Article • Clinical & Experimental Allergy, February 2005, Wiley

    Dr. Erwin L J Roggen

  63. Anin silico method using an epitope motif database for predicting the location of antigenic determinants on proteins in a structural context

    Article • Journal of Molecular Recognition, January 2005, Wiley

    Dr. Erwin L J Roggen

  64. CD27- CD4+ memory T cells define a differentiated memory population at both the functional and transcriptional levels

    Article • Immunology, November 2004, Wiley

    Dr. Erwin L J Roggen

  65. Isolation of high-affinity human IgE and IgG antibodies recognising Bet v 1 and Humicola lanuginosa lipase from combinatorial phage libraries

    Article • Molecular Immunology, August 2004, Elsevier

    Dr. Erwin L J Roggen

  66. STDs in women attending family planning clinics: A case study in Addis Ababa

    Article • Social Science & Medicine, February 1997, Elsevier

    Dr. Erwin L J Roggen

  67. In vitro stimulation of peripheral blood mononuclear cells (PBMC) from HIV- and HIV+ chancroid patients by Haemophilus ducreyi antigens

    Article • Clinical & Experimental Immunology, November 1995, Oxford University Press (OUP)

    Dr. Erwin L J Roggen

  68. Monoclonal antibodies againstHaemophilus ducreyi lipooligosaccharide and their diagnostic usefulness

    Article • European Journal of Clinical Microbiology & Infectious Diseases, October 1995, Springer Science + Business Media

    Dr. Erwin L J Roggen

  69. Localisation and immunological properties of a 24-kDa surface protein of Haemophilus ducreyi

    Article • Journal of Medical Microbiology, September 1995, Society for General Microbiology

    Dr. Erwin L J Roggen

  70. Seroepidemiological Studies of Haemophilus ducreyi Infection in Ethiopian Women

    Article • Sexually Transmitted Diseases, September 1994, Wolters Kluwer Health

    Dr. Erwin L J Roggen

  71. Seroprevalence and Incidence of Sexually Transmitted Diseases in a Rural Ugandan Population

    Article • International Journal of STD & AIDS, September 1994, SAGE Publications

    Dr. Erwin L J Roggen

  72. A socioeconomic, clinical and serological study in an African City of prostitutes and women still married to their first husband

    Article • Social Science & Medicine, August 1994, Elsevier

    Dr. Erwin L J Roggen

  73. Human T Cell Lymphotropic Virus Type I Infection among Female Sex Workers in Peru

    Article • The Journal of Infectious Diseases, April 1994, Oxford University Press (OUP)

    Dr. Erwin L J Roggen

  74. Enzyme Immunoassays (ElAs) for the Detection of Anti-Haemophilus ducreyi Serum IgA, IgG, and IgM Antibodies

    Article • Sexually Transmitted Diseases, January 1994, Wolters Kluwer Health

    Dr. Erwin L J Roggen

  75. Calmodulin-binding proteins in granule and plasma membranes from bovine chromaffin cells

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, November 1990, Elsevier

    Dr. Erwin L J Roggen

  76. Isolation and characterization of cytoplasmic poly(A) polymerase from cryptobiotic gastrulae of Artemia salina

    Article • European Journal of Biochemistry, March 1985, Wiley

    Dr. Erwin L J Roggen

  77. Identification and properties of the 38000-M, poly(A)-binding protein of non-polysomal messenger ribonucleoproteins of cryptobiotic gastrulae of Artemia salina

    Article • European Journal of Biochemistry, February 1984, Wiley

    Dr. Erwin L J Roggen