All Stories

  1. FragmentScope - exploring the fragment space with learned surface representations

    Article • December 2025, openRxiv

    Davide M Ferraris

  2. Single-molecule imaging and molecular dynamics simulations reveal early activation of the MET receptor in cells

    Article • Nature Communications, November 2024, Springer Science + Business Media

    Davide M Ferraris

  3. An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent

    Article • Acta Crystallographica Section D Structural Biology, May 2024, International Union of Crystallography

    Davide M Ferraris

  4. AI is a viable alternative to high throughput screening: a 318-target study

    Article • Scientific Reports, April 2024, Springer Science + Business Media

    Davide M Ferraris, Jose A. Costoya, Dr Kiterie ME Faller, Dr Graeme L Conn

  5. Single-molecule FRET and molecular dynamics simulations reveal early activation steps of MET receptor byListeria monocytogenes

    Article • December 2023, Cold Spring Harbor Laboratory Press

    Davide M Ferraris

  6. Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor

    Article • FEBS Letters, June 2023, Wiley

    Davide M Ferraris

  7. Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety

    Article • Journal of Medicinal Chemistry, September 2022, American Chemical Society (ACS)

    Davide M Ferraris

  8. Curcumin-based-fluorescent probes targeting ALDH1A3 as a promising tool for glioblastoma precision surgery and early diagnosis

    Article • Communications Biology, September 2022, Springer Science + Business Media

    Davide M Ferraris

  9. The integration of AlphaFold-predicted and crystal structures of human trans-3-hydroxy-l-proline dehydratase reveals a regulatory catalytic mechanism

    Article • Computational and Structural Biotechnology Journal, January 2022, Elsevier

    Davide M Ferraris

  10. Engineering, Characterization, and Biological Evaluation of an Antibody Targeting the HGF Receptor

    Article • Frontiers in Immunology, December 2021, Frontiers

    Davide M Ferraris

  11. A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro

    Article • Cancers, January 2021, MDPI AG

    Davide M Ferraris

  12. A highly selective electrochemical assay based on the Sakaguchi reaction for the detection of protein arginine methylation state

    Article • Electrochemistry Communications, September 2020, Elsevier

    Davide M Ferraris

  13. Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment

    Article • Pathogens, May 2020, MDPI AG

    Davide M Ferraris

  14. Structure of Thermococcus litoralis Δ1-pyrroline-2-carboxylate reductase in complex with NADH and L-proline

    Article • Acta Crystallographica Section D Structural Biology, April 2020, International Union of Crystallography

    Davide M Ferraris

  15. Targeting NAD-dependent dehydrogenases in drug discovery against infectious diseases and cancer

    Article • Biochemical Society Transactions, April 2020, Portland Press Ltd.

    Davide M Ferraris

  16. Imidazo[1,2-a]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells

    Article • Journal of Medicinal Chemistry, March 2020, American Chemical Society (ACS)

    Davide M Ferraris

  17. Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-a]pyridines against the 1A Family

    Article • ACS Medicinal Chemistry Letters, March 2020, American Chemical Society (ACS)

    Davide M Ferraris

  18. Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity

    Article • Scientific Reports, January 2020, Springer Science + Business Media

    Davide M Ferraris

  19. Structure of Thermococcus litoralis trans-3-hydroxy-l-proline dehydratase in the free and substrate-complexed form

    Article • Biochemical and Biophysical Research Communications, August 2019, Elsevier

    Davide M Ferraris

  20. Synthesis and Structure–Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH

    Article • European Journal of Medicinal Chemistry, July 2019, Elsevier

    Davide M Ferraris

  21. The Synthesis of Kynurenic Acid in Mammals: An Updated Kynurenine Aminotransferase Structural KATalogue

    Article • Frontiers in Molecular Biosciences, February 2019, Frontiers

    Davide M Ferraris

  22. Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag in covalent complex with a fluorescent probe

    Article • Biochemical and Biophysical Research Communications, June 2018, Elsevier

    Davide M Ferraris

  23. Hit discovery of Mycobacterium tuberculosis inosine 5′-monophosphate dehydrogenase, GuaB2, inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, June 2018, Elsevier

    Davide M Ferraris

  24. Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure–Activity As Potential Antituberculosis Agents

    Article • Journal of Medicinal Chemistry, May 2018, American Chemical Society (ACS)

    Davide M Ferraris

  25. Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages

    Article • ChemMedChem, February 2018, Wiley

    Dr Simone Brogi, Davide M Ferraris

  26. Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets

    Article • Pathogens, February 2018, MDPI AG

    Davide M Ferraris

  27. Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1

    Article • Bioorganic & Medicinal Chemistry Letters, February 2018, Elsevier

    Davide M Ferraris

  28. Absolute structure and structure-function relationships of 4R,2′R and 4S,2′S Pidotimod ®

    Article • Journal of Molecular Structure, November 2017, Elsevier

    Davide M Ferraris

  29. Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis

    Article • Scientific Reports, April 2017, Springer Science + Business Media

    Davide M Ferraris

  30. Biochemical and structural investigations on phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis

    Article • PLOS One, April 2017, PLOS

    Davide M Ferraris

  31. Structures of citrate synthase and malate dehydrogenase of M ycobacterium tuberculosis

    Article • Proteins Structure Function and Bioinformatics, January 2015, Wiley

    Davide M Ferraris

  32. Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

    Article • Bioorganic & Medicinal Chemistry Letters, June 2014, Elsevier

    Davide M Ferraris

  33. Crystal structure of theMycobacterium tuberculosisphosphate binding protein PstS3

    Article • Proteins Structure Function and Bioinformatics, March 2014, Wiley

    Davide M Ferraris

  34. Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cells

    Article • BMC Biophysics, January 2013, Springer Science + Business Media

    Davide M Ferraris

  35. Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates

    Article • Biological Chemistry, January 2012, De Gruyter

    Davide M Ferraris

  36. Crystal Structure ofMycobacterium tuberculosisZinc-dependent Metalloprotease-1 (Zmp1), a Metalloprotease Involved in Pathogenicity

    Article • Journal of Biological Chemistry, August 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Davide M Ferraris

  37. Ligand-Mediated Dimerization of the Met Receptor Tyrosine Kinase by the Bacterial Invasion Protein InlB

    Article • Journal of Molecular Biology, January 2010, Elsevier

    Davide M Ferraris

  38. Structure of the Human Receptor Tyrosine Kinase Met in Complex with the Listeria Invasion Protein InlB

    Article • Cell, July 2007, Elsevier

    Davide M Ferraris

  39. Zinc-Dependent Metalloprotease-1 (Zmp1)

    Article • March 2004, Wiley

    Davide M Ferraris