All Stories

  1. AI is a viable alternative to high throughput screening: a 318-target study
  2. PARP1: Opportunities of Developing New Drugs for an Old Target
  3. Inhibiting HER3 Hyperphosphorylation in HER2‐Overexpressing Breast Cancer through Multimodal Therapy with Branched Gold Nanoshells
  4. A New Opportunity for “Old” Molecules: Targeting PARP1 Activity through a Non-Enzymatic Mechanism
  5. Cancer cells escape the immune system by increasing stemness through epigenetic reprogramming
  6. Editorial: Cellular stress in blood cancer: Pathophysiology and therapeutic opportunities
  7. Development of a biosensor based on a new marine luciferase fused to an affibody to assess Her2 expression in living cells
  8. Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration
  9. New insights into the relevance of mobile DNA to cancer resistance in blind mole rats: new lessons for cancer therapy
  10. From neural stem cells to glioblastoma: A natural history of GBM recapitulated in vitro
  11. SARS-CoV-2 infection in K18-ACE2 transgenic mice replicates human pulmonary disease in COVID-19
  12. PARP1 Deficiency Reduces Tumour Growth by Decreasing E2F1 Hyperactivation: A Novel Mechanism in the Treatment of Cancer
  13. Immortalization of a cell line with neural stem cell characteristics derived from mouse embryo brain
  14. A Bio-inspired Hypoxia Sensor using HIF1a-Oxygen-Dependent Degradation Domain
  15. NK Cell-Based Glioblastoma Immunotherapy
  16. Expression of myostatin in human hematopoietic cells unveils novel autocrine/paracrine actions for the hormone
  17. Uncoupling Oncogene-Induced Senescence (OIS) and DNA Damage Response (DDR) triggered by DNA hyper-replication: lessons from primary mouse embryo astrocytes (MEA)
  18. RB mutation and RAS overexpression induce resistance to NK cell-mediated cytotoxicity in glioma cells
  19. The Antimitotic Potential of PARP Inhibitors, An Unexplored Therapeutic Alternative
  20. Lipoprotein internalisation induced by oncogenic AMPK activation is essential to maintain glioblastoma cell growth
  21. Fluorescent Drug-Loaded, Polymeric-Based, Branched Gold Nanoshells for Localized Multimodal Therapy and Imaging of Tumoral Cells
  22. NIR-light active hybrid nanoparticles for combined imaging and bimodal therapy of cancerous cells
  23. AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors
  24. Defining hypoxic microenvironments by non-invasive functional optical imaging
  25. Functional Optical Imaging-based Biosensors
  26. Biomimetic Nanohybrids for Combined imaging and Cancer Therapy
  27. The maintenance of mitochondrial genetic stability is crucial during the oncogenic process
  28. The Mitochondrial Genome Is a “Genetic Sanctuary” during the Oncogenic Process
  29. Molecular Imaging of Hypoxia Using Genetic Biosensors
  30. Resistance of neonatal primary astrocytes against Fas-induced apoptosis depends on silencing of caspase 8
  31. A novel BRET-based genetically encoded biosensor for functional imaging of hypoxia
  32. Retinoblastoma Loss Modulates DNA Damage Response Favoring Tumor Progression
  33. Interferon-β protects astrocytes against tumour necrosis factor-induced apoptosis via activation of p38 mitogen-activated protein kinase
  34. Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation
  35. Functional analysis of the role of POK transcriptional repressors
  36. Disruption of PLZP in Mice Leads to Increased T-Lymphocyte Proliferation, Cytokine Production, and Altered Hematopoietic Stem Cell Homeostasis
  37. Essential role of Plzf in maintenance of spermatogonial stem cells
  38. Plzf Mediates Transcriptional Repression of HoxD Gene Expression through Chromatin Remodeling
  39. Activation of Human Somatostatin Receptor 2 Promotes Apoptosis Through a Mechanism that is Independent from Induction of p53
  40. The role of promyelocytic leukemia zinc finger and promyelocytic leukemia in leukemogenesis and development
  41. Role of Growth Hormone Receptor in HL-60 Cell Survival
  42. Expression of growth hormone receptor in the human brain
  43. Activation of Growth Hormone Receptor Delivers an Antiapoptotic Signal: Evidence for a Role of Akt in This Pathway1
  44. Activation of Growth Hormone Receptor Delivers an Antiapoptotic Signal: Evidence for a Role of Akt in This Pathway
  45. Salivary gland is capable of GH synthesis under GHRH stimulation
  46. Correlation of Pit-1 Gene Expression and Pit-1 Content with Proliferation and Differentiation in Human Myeloid Leukemic Cells
  47. Expression of the Human Growth Hormone Normal Gene (hGH-N) in Proliferating and Differentiated HL-60 Cells