All Stories

  1. AI is a viable alternative to high throughput screening: a 318-target study

    Article • Scientific Reports, April 2024, Springer Science + Business Media

    Davide M Ferraris, Jose A. Costoya

  2. PARP1: Opportunities of Developing New Drugs for an Old Target

    Article • January 2024, Springer Science + Business Media

    Jose A. Costoya

  3. Inhibiting HER3 Hyperphosphorylation in HER2‐Overexpressing Breast Cancer through Multimodal Therapy with Branched Gold Nanoshells

    Article • Small, August 2023, Wiley

    Jose A. Costoya

  4. A New Opportunity for “Old” Molecules: Targeting PARP1 Activity through a Non-Enzymatic Mechanism

    Article • International Journal of Molecular Sciences, May 2023, MDPI AG

    Jose A. Costoya

  5. Cancer cells escape the immune system by increasing stemness through epigenetic reprogramming

    Article • Cellular and Molecular Immunology, November 2022, Springer Science + Business Media

    Jose A. Costoya

  6. Editorial: Cellular stress in blood cancer: Pathophysiology and therapeutic opportunities

    Article • Frontiers in Oncology, September 2022, Frontiers

    Jose A. Costoya

  7. Development of a biosensor based on a new marine luciferase fused to an affibody to assess Her2 expression in living cells

    Article • Analytica Chimica Acta, August 2022, Elsevier

    Jose A. Costoya

  8. Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration

    Article • International Journal of Pharmaceutics, June 2022, Elsevier

    Jose A. Costoya

  9. New insights into the relevance of mobile DNA to cancer resistance in blind mole rats: new lessons for cancer therapy

    Article • Cellular and Molecular Immunology, January 2022, Springer Science + Business Media

    Jose A. Costoya

  10. From neural stem cells to glioblastoma: A natural history of GBM recapitulated in vitro

    Article • Journal of Cellular Physiology, May 2021, Wiley

    Jose A. Costoya

  11. SARS-CoV-2 infection in K18-ACE2 transgenic mice replicates human pulmonary disease in COVID-19

    Article • Cellular and Molecular Immunology, January 2021, Springer Science + Business Media

    Jose A. Costoya

  12. PARP1 Deficiency Reduces Tumour Growth by Decreasing E2F1 Hyperactivation: A Novel Mechanism in the Treatment of Cancer

    Article • Cancers, October 2020, MDPI AG

    Jose A. Costoya

  13. Immortalization of a cell line with neural stem cell characteristics derived from mouse embryo brain

    Article • Developmental Dynamics, August 2019, Wiley

    Jose A. Costoya

  14. A Bio-inspired Hypoxia Sensor using HIF1a-Oxygen-Dependent Degradation Domain

    Article • Scientific Reports, May 2019, Springer Science + Business Media

    Jose A. Costoya

  15. NK Cell-Based Glioblastoma Immunotherapy

    Article • Cancers, December 2018, MDPI AG

    Jose A. Costoya

  16. Expression of myostatin in human hematopoietic cells unveils novel autocrine/paracrine actions for the hormone

    Article • Journal of Cellular Physiology, October 2018, Wiley

    Jose A. Costoya

  17. Uncoupling Oncogene-Induced Senescence (OIS) and DNA Damage Response (DDR) triggered by DNA hyper-replication: lessons from primary mouse embryo astrocytes (MEA)

    Article • Scientific Reports, October 2017, Springer Science + Business Media

    Jose A. Costoya

  18. RB mutation and RAS overexpression induce resistance to NK cell-mediated cytotoxicity in glioma cells

    Article • Cancer Cell International, June 2015, Springer Science + Business Media

    Jose A. Costoya

  19. The Antimitotic Potential of PARP Inhibitors, An Unexplored Therapeutic Alternative

    Article • Current Topics in Medicinal Chemistry, December 2014, Bentham Science Publishers

    Jose A. Costoya

  20. Lipoprotein internalisation induced by oncogenic AMPK activation is essential to maintain glioblastoma cell growth

    Article • European Journal of Cancer, December 2014, Elsevier

    Jose A. Costoya

  21. Fluorescent Drug-Loaded, Polymeric-Based, Branched Gold Nanoshells for Localized Multimodal Therapy and Imaging of Tumoral Cells

    Article • ACS Nano, March 2014, American Chemical Society (ACS)

    Jose A. Costoya

  22. NIR-light active hybrid nanoparticles for combined imaging and bimodal therapy of cancerous cells

    Article • Journal of Materials Chemistry B, January 2014, Royal Society of Chemistry

    Jose A. Costoya

  23. AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors

    Article • Cancer Research, January 2013, American Association for Cancer Research (AACR)

    Jose A. Costoya

  24. Defining hypoxic microenvironments by non-invasive functional optical imaging

    Article • European Journal of Cancer, January 2013, Elsevier

    Jose A. Costoya

  25. Functional Optical Imaging-based Biosensors

    Article • July 2012, Taylor & Francis

    Jose A. Costoya

  26. Biomimetic Nanohybrids for Combined imaging and Cancer Therapy

    Article • MRS Proceedings, January 2012, Cambridge University Press

    Jose A. Costoya

  27. The maintenance of mitochondrial genetic stability is crucial during the oncogenic process

    Article • Communicative & Integrative Biology, January 2012, Taylor & Francis

    Jose A. Costoya

  28. The Mitochondrial Genome Is a “Genetic Sanctuary” during the Oncogenic Process

    Article • PLOS One, August 2011, PLOS

    Jose A. Costoya

  29. Molecular Imaging of Hypoxia Using Genetic Biosensors

    Article • October 2010, Springer Science + Business Media

    Jose A. Costoya

  30. Resistance of neonatal primary astrocytes against Fas-induced apoptosis depends on silencing of caspase 8

    Article • Neuroscience Letters, August 2010, Elsevier

    Jose A. Costoya

  31. A novel BRET-based genetically encoded biosensor for functional imaging of hypoxia

    Article • Biosensors and Bioelectronics, June 2009, Elsevier

    Jose A. Costoya

  32. Retinoblastoma Loss Modulates DNA Damage Response Favoring Tumor Progression

    Article • PLOS One, November 2008, PLOS

    Jose A. Costoya

  33. Interferon-β protects astrocytes against tumour necrosis factor-induced apoptosis via activation of p38 mitogen-activated protein kinase

    Article • Experimental Cell Research, July 2008, Elsevier

    Jose A. Costoya

  34. Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation

    Article • Oncogene, February 2008, Springer Science + Business Media

    Jose A. Costoya

  35. Functional analysis of the role of POK transcriptional repressors

    Article • Briefings in Functional Genomics and Proteomics, March 2007, Oxford University Press (OUP)

    Jose A. Costoya

  36. Disruption of PLZP in Mice Leads to Increased T-Lymphocyte Proliferation, Cytokine Production, and Altered Hematopoietic Stem Cell Homeostasis

    Article • Molecular and Cellular Biology, December 2004, ASM Journals

    Jose A. Costoya

  37. Essential role of Plzf in maintenance of spermatogonial stem cells

    Article • Nature Genetics, May 2004, Springer Science + Business Media

    Jose A. Costoya

  38. Plzf Mediates Transcriptional Repression of HoxD Gene Expression through Chromatin Remodeling

    Article • Developmental Cell, October 2002, Elsevier

    Professor Paolo Samorì, Jose A. Costoya

  39. Activation of Human Somatostatin Receptor 2 Promotes Apoptosis Through a Mechanism that is Independent from Induction of p53

    Article • Cellular Physiology and Biochemistry, March 2002, Karger Publishers

    jesus devesa, Jose A. Costoya

  40. The role of promyelocytic leukemia zinc finger and promyelocytic leukemia in leukemogenesis and development

    Article • Current Opinion in Hematology, July 2001, Wolters Kluwer Health

    Jose A. Costoya

  41. Role of Growth Hormone Receptor in HL-60 Cell Survival

    Article • Molecular Cell Biology Research Communications, July 2000, Elsevier

    jesus devesa, Jose A. Costoya

  42. Expression of growth hormone receptor in the human brain

    Article • Neuroscience Letters, March 2000, Elsevier

    Jose A. Costoya

  43. Activation of Growth Hormone Receptor Delivers an Antiapoptotic Signal: Evidence for a Role of Akt in This Pathway1

    Article • Endocrinology, December 1999, Endocrine Society

    jesus devesa, Jose A. Costoya

  44. Activation of Growth Hormone Receptor Delivers an Antiapoptotic Signal: Evidence for a Role of Akt in This Pathway

    Article • Endocrinology, December 1999, Endocrine Society

    Jose A. Costoya

  45. Salivary gland is capable of GH synthesis under GHRH stimulation

    Article • Journal of Endocrinology, February 1999, Bioscientifica

    Jose A. Costoya

  46. Correlation of Pit-1 Gene Expression and Pit-1 Content with Proliferation and Differentiation in Human Myeloid Leukemic Cells

    Article • Experimental Cell Research, November 1998, Elsevier

    jesus devesa, Jose A. Costoya

  47. Expression of the Human Growth Hormone Normal Gene (hGH-N) in Proliferating and Differentiated HL-60 Cells

    Article • Experimental Cell Research, October 1996, Elsevier

    jesus devesa, Jose A. Costoya