All Stories

  1. Single- vs. Multi-Walled Carbon Nanotubes: Differential Cellular Stress and Lipid Metabolism Effects in Macrophage Models

    Article • Nanomaterials, September 2025, MDPI AG

    Dr David Matallanas

  2. Multiple Myeloma Derived Extracellular Vesicle Uptake by Monocyte Cells Stimulates IL-6 and MMP-9 Secretion and Promotes Cancer Cell Migration and Proliferation

    Article • Cancers, February 2024, MDPI AG

    Dr David Matallanas

  3. Proteomic Mapping of the Interactome of KRAS Mutants Identifies New Features of RAS Signalling Networks and the Mechanism of Action of Sotorasib

    Article • Cancers, August 2023, MDPI AG

    Dr David Matallanas

  4. Cyclophilin A Isomerisation of Septin 2 Mediates Abscission during Cytokinesis

    Article • International Journal of Molecular Sciences, July 2023, MDPI AG

    Dr David Matallanas

  5. Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma

    Article • Life Science Alliance, August 2022, Life Science Alliance, LLC

    Dr David Matallanas

  6. Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner

    Article • Cell Death and Disease, August 2022, Springer Science + Business Media

    Dr David Matallanas

  7. Proteasomal downregulation of the pro-apoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma

    Article • February 2022, Cold Spring Harbor Laboratory Press

    Dr David Matallanas

  8. Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling

    Article • Genes, April 2021, MDPI AG

    Dr David Matallanas

  9. Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling

    Article • March 2021, MDPI AG

    Dr David Matallanas

  10. IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway

    Article • Cells, February 2021, MDPI AG

    Dr David Matallanas

  11. IQGAP is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway

    Article • February 2021, MDPI AG

    Dr David Matallanas

  12. The Ins and Outs of RAS Effector Complexes

    Article • Biomolecules, February 2021, MDPI AG

    Dr David Matallanas

  13. The Ins and Outs of RAS Effector Complexes

    Article • January 2021, MDPI AG

    Dr David Matallanas

  14. Accurate prediction of kinase-substrate networks using knowledge graphs

    Article • PLoS Computational Biology, December 2020, PLOS

    Dr David Matallanas

  15. Examination and characterisation of burst spinal cord stimulation on cerebrospinal fluid cellular and protein constituents in patient responders with chronic neuropathic pain - A Pilot Study

    Article • Journal of Neuroimmunology, July 2020, Elsevier

    Dr David Matallanas

  16. Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis

    Article • Thorax, April 2020, BMJ

    Dr David Matallanas

  17. Genetic Deletion of Zebrafish Rab28 Causes Defective Outer Segment Shedding, but Not Retinal Degeneration

    Article • Frontiers in Cell and Developmental Biology, March 2020, Frontiers

    Dr David Matallanas

  18. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

    Article • Nature Communications, January 2020, Springer Science + Business Media

    Dr David Matallanas

  19. RASSF1A Tumour Suppressor: Target the Network for Effective Cancer Therapy

    Article • Cancers, January 2020, MDPI AG

    Dr David Matallanas

  20. Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles

    Article • Cell Biology and Toxicology, July 2019, Springer Science + Business Media

    Dr David Matallanas

  21. An Integrative Computational Approach for a Prioritization of Key Transcription Regulators Associated With Nanomaterial-Induced Toxicity

    Article • Toxicological Sciences, July 2019, Oxford University Press (OUP)

    Dr David Matallanas

  22. VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle

    Article • Journal of Cell Science, July 2019, The Company of Biologists

    Dr David Matallanas

  23. All over the place: deciphering HRAS signaling from different subcellular compartments

    Article • Molecular & Cellular Oncology, May 2019, Taylor & Francis

    Dr David Matallanas

  24. An Integrated Global Analysis of Compartmentalized HRAS Signaling

    Article • Cell Reports, March 2019, Elsevier

    Dr David Matallanas

  25. Quantifying the Kinase Activities of MST1/2

    Article • December 2018, Springer Science + Business Media

    Dr David Matallanas

  26. Increased Virulence of Bloodstream Over Peripheral Isolates of P. aeruginosa Identified Through Post-transcriptional Regulation of Virulence Factors

    Article • Frontiers in Cellular and Infection Microbiology, October 2018, Frontiers

    Dr David Matallanas

  27. Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling

    Article • Cell Systems, August 2018, Elsevier

    Dr David Matallanas

  28. Nanoparticles Can Wrap Epithelial Cell Membranes and Relocate Them Across the Epithelial Cell Layer

    Article • Nano Letters, July 2018, American Chemical Society (ACS)

    Dr David Matallanas

  29. BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer

    Article • Oncotarget, February 2018, Impact Journals, LLC

    Dr David Matallanas

  30. RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73

    Article • Nature Communications, January 2018, Springer Science + Business Media

    Dr David Matallanas

  31. Characterisation of hras local signal transduction networks using engineered site-specific exchange factors

    Article • Small GTPases, November 2017, Taylor & Francis

    Dr David Matallanas

  32. A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events

    Article • Cell Systems, October 2017, Elsevier

    Dr David Matallanas

  33. Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

    Article • Stem Cells, June 2017, Wiley

    Dr Congshan Sun, Dr Abdalla Mohamed, Dr David Matallanas

  34. The spatiotemporal regulation of RAS signalling

    Article • Biochemical Society Transactions, October 2016, Portland Press Ltd.

    Dr David Matallanas

  35. SARAH Domain-Mediated MST2-RASSF Dimeric Interactions

    Article • PLoS Computational Biology, October 2016, PLOS

    Dr Goar Sanchez, Dr David Matallanas

  36. The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair

    Article • Genes, June 2016, MDPI AG

    Dr David Matallanas

  37. Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device

    Article • Cell Cycle, January 2015, Taylor & Francis

    Professor Boris N. Kholodenko, Dr David Matallanas

  38. One Hippo and many masters: differential regulation of the Hippo pathway in cancer: Figure 1

    Article • Biochemical Society Transactions, August 2014, Portland Press Ltd.

    Dr David Matallanas

  39. Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling

    Article • Nature Cell Biology, June 2014, Springer Science + Business Media

    Dr David Matallanas, Professor Boris N. Kholodenko

  40. HGF Induces Epithelial-to-Mesenchymal Transition by Modulating the Mammalian Hippo/MST2 and ISG15 Pathways

    Article • Journal of Proteome Research, June 2014, American Chemical Society (ACS)

    Dr David Matallanas

  41. The Differential Effects of Wild-Type and Mutated K-Ras on MST2 Signaling Are Determined by K-Ras Activation Kinetics

    Article • Molecular and Cellular Biology, March 2013, ASM Journals

    Dr David Matallanas

  42. Signalling by protein phosphatases and drug development: a systems-centred view

    Article • European Journal of Biochemistry, March 2012, Wiley

    Dr David Matallanas, Professor Boris N. Kholodenko

  43. Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia

    Article • Leukemia, March 2012, Springer Science + Business Media

    Dr David Matallanas

  44. Mutant K-Ras Activation of the Proapoptotic MST2 Pathway Is Antagonized by Wild-Type K-Ras

    Article • Molecular Cell, December 2011, Elsevier

    Dr David Matallanas

  45. Raf Family Kinases: Old Dogs Have Learned New Tricks

    Article • Genes & Cancer, March 2011, SAGE Publications

    Marc Birtwistle, Dr David Matallanas

  46. The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-κB signaling pathways

    Article • Oncogene, May 2010, Springer Science + Business Media

    Dr David Matallanas

  47. Proapoptotic Kinase MST2 Coordinates Signaling Crosstalk between RASSF1A, Raf-1, and Akt

    Article • Cancer Research, January 2010, American Association for Cancer Research (AACR)

    Dr David Matallanas

  48. RAN GTPase Is a RASSF1A Effector Involved in Controlling Microtubule Organization

    Article • Current Biology, July 2009, Elsevier

    Dr David Matallanas

  49. RASSF2 associates with and stabilizes the proapoptotic kinase MST2

    Article • Oncogene, June 2009, Springer Science + Business Media

    Dr David Matallanas

  50. Proteomics and phosphoproteomics for the mapping of cellular signalling networks

    Article • PROTEOMICS, November 2008, Wiley

    Dr David Matallanas

  51. RASSF1A Elicits Apoptosis through an MST2 Pathway Directing Proapoptotic Transcription by the p73 Tumor Suppressor Protein

    Article • Molecular Cell, September 2007, Elsevier

    Professor Manuela Baccarini, Dr David Matallanas

  52. Distinct Utilization of Effectors and Biological Outcomes Resulting from Site-Specific Ras Activation: Ras Functions in Lipid Rafts and Golgi Complex Are Dispensable for Proliferation and Transformation

    Article • Molecular and Cellular Biology, January 2006, ASM Journals

    Dr David Matallanas

  53. Mammalian Sterile 20-Like Kinases in Tumor Suppression: An Emerging Pathway

    Article • Cancer Research, July 2005, American Association for Cancer Research (AACR)

    Dr David Matallanas

  54. Myc Antagonizes Ras-mediated Growth Arrest in Leukemia Cells through the Inhibition of the Ras-ERK-p21Cip1Pathway

    Article • Journal of Biological Chemistry, November 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David Matallanas

  55. Subcellular Localization Determines the Protective Effects of Activated ERK2 against Distinct Apoptogenic Stimuli in Myeloid Leukemia Cells

    Article • Journal of Biological Chemistry, June 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David Matallanas

  56. Activation of H-Ras in the Endoplasmic Reticulum by the RasGRF Family Guanine Nucleotide Exchange Factors

    Article • Molecular and Cellular Biology, February 2004, ASM Journals

    Dr David Matallanas

  57. Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

    Article • The EMBO Journal, July 2003, Wiley

    Dr David Matallanas

  58. Differences on the Inhibitory Specificities of H-Ras, K-Ras, and N-Ras (N17) Dominant Negative Mutants Are Related to Their Membrane Microlocalization

    Article • Journal of Biological Chemistry, November 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David Matallanas

  59. Maintenance of Cdc42 GDP-bound State by Rho-GDI Inhibits MAP Kinase Activation by the Exchange Factor Ras-GRF

    Article • Journal of Biological Chemistry, April 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David Matallanas

  60. The Rho Family GTPase Cdc42 Regulates the Activation of Ras/MAP Kinase by the Exchange Factor Ras-GRF

    Article • Journal of Biological Chemistry, June 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David Matallanas