Professor Daniel S. Brewer
University of East Anglia
Professor, Medicine And Medical Sciences
United Kingdom
My co-authors include
Dr Elizabeth L Christie
Shea P Connell
Professor Ming-Qing Du
Find me at
My Publications
Detecting new potential lines of attack against prostate cancer based on genetic inform...
Nature Genetics
April 2018
We obtained genetic information from the tumours of 112 men with prostate cancer and pooled it with data from other studies, together analysing samples from 930 prostate cancer patients. A detaile...
Study of mechanisms to "knock out" genes in prostate cancer
PLoS Genetics
September 2017
Cancer is a genetic disease where changes in DNA cause alterations in the control of cellular systems leading to unchecked growth. Copy number changes, including duplications, amplifications, and d...
DESNT: A Poor Prognosis Category of Human Prostate Cancer
European Urology Focus
March 2017
The evolutionary history of lethal metastatic prostate cancer
Nature
April 2015
Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple ind...
Nature Genetics
March 2015
New prostate cancer urine test shows who needs treatment and when
BJU International
June 2019
We developed the Prostate Urine Risk (PUR) test using machine learning to look at gene expression in urine from samples collected from 537 men attending a clinic with suspected prostate cancer. By ...
Detecting viruses in tumour tissue to discover links between cancer and infection
Nature Genetics
February 2020
It is well established that infectious agents, such as bacteria and viruses, are involved in the development of a variety of human cancers and it is estimated that infectious agents are involved in...
New types of prostate cancer have been discovered and linked with how patient progress
British Journal of Cancer
March 2020
We have discovered why some prostate cancers are more aggressive, spread to different parts of the body, and ultimately cause death. Recently we developed a test to distinguish aggressive prostate...
Overlap of biological markers of prostate cancer reveals information about how progress...
Genes
July 2020
How prostate cancer develops is highly variable and this has led to the development of multiple tests using biological markers detectable in cells to try and predict how long it will take for the d...
Testing computational tools to detect bacteria and viruses in human samples of DNA
October 2019
There is a huge variety of computational methods coming out recently that each claim to be the best at detecting pathogens (ie bacteria/viruses). We apply multiple tools to real and computer simula...
A new urine test for aggressive prostate cancer combining two different approaches
Cancers
April 2021
In this paper we look at combining two different types of measurements taken from different parts of urine, to see if they can help us better detect prostate cancer and determine how agressive it i...
A potenital new test from urine for prostate cancer
Cancers
April 2022
In this study, we develop a test that can predict whether a patient has prostate cancer and how aggressive that cancer is. This test combines clinical measurements, levels of four genes collected f...
A prostate cancer patient's genetic code may be able to predict the correct treatment
European Urology
May 2022
Prostate cancer patients with particular genetic mutations have a higher chance of relapsing after initial radical treatment, potentially providing opportunities to identify patients who might need...
Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups
European Urology Oncology
April 2022
APOBEC3 mutational signatures are associated with extensive and diverse genomic instabi...
BMC Biology
May 2022
Urine risk score PUR can distinguish the aggressiveness of disease in fine detail.
Life
November 2021
Prostate cancer evolution from multilineage primary to single lineage metastases with i...
Nature Communications
October 2020
Development of a multivariable risk model integrating urinary cell DNA methylation and ...
The Prostate
March 2020
Pan-cancer analysis of whole genomes
Nature
February 2020
Potential for diagnosis of infectious disease from the 100,000 Genomes Project Metageno...
Wellcome Open Research
October 2019
Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and ...
Frontiers in Pharmacology
March 2019
epiCaPture: A Urine DNA Methylation Test for Early Detection of Aggressive Prostate Cancer
JCO Precision Oncology
January 2019
A urine-based DNA methylation assay, ProCUrE, to identify clinically significant prosta...
Clinical Epigenetics
November 2018
The landscape of viral associations in human cancers
November 2018
Mutational signatures of ionizing radiation in second malignancies
Nature Communications
September 2016
Prostate Single Nucleotide Polymorphism Provides a Crucial Clue to Cancer Aggression in...
European Urology
February 2016
Integration of copy number and transcriptomics provides risk stratification in prostate...
EBioMedicine
September 2015
Erratum: Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer i...
Nature Genetics
May 2015
Mutation detection in formalin-fixed prostate cancer biopsies taken at the time of diag...
Journal of Clinical Pathology
January 2015
HES5 silencing is an early and recurrent change in prostate tumourigenesis
January 2015
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
eLife
October 2014
A gene expression based predictor for high risk myeloma treated with intensive therapy ...
Leukemia & Lymphoma
August 2014
Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer...
Science
July 2014
Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer
British Journal of Cancer
January 2014
Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target ...
BMC Genomics
January 2014
Improved risk stratification in myeloma using a microRNA-based classifier
British Journal of Haematology
May 2013
Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer
British Journal of Cancer
May 2013
Prognostic value of blood mRNA expression signatures in castration-resistant prostate c...
The Lancet Oncology
November 2012
Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in pros...
Modern Pathology
August 2012
Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in pros...
Modern Pathology
March 2012
Modelling Transcription Factor Activity
September 2011
A Gene Expression-Based Predictor for Myeloma Patients at High Risk of Developing Bone ...
Clinical Cancer Research
August 2011
siRNA Knockdown of Ribosomal Protein Gene RPL19 Abrogates the Aggressive Phenotype of H...
PLoS ONE
July 2011
A HIF-Regulated VHL-PTP1B-Src Signaling Axis Identifies a Therapeutic Target in Renal C...
Science Translational Medicine
June 2011
PRKC- Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and ...
Genes & Cancer
May 2010
Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low a...
British Journal of Cancer
January 2010
A census of amplified and overexpressed human cancer genes
Nature Reviews Drug Discovery
January 2010
Dissection of a complex transcriptional response using genome-wide transcriptional mode...
Molecular Systems Biology
November 2009
Integration ofERGgene mapping and gene-expression profiling identifies distinct categor...
BJU International
May 2009
Interlaboratory and Interplatform Comparison of Microarray Gene Expression Analysis of ...
OMICS A Journal of Integrative Biology
April 2009
rHVDM: an R package to predict the activity and targets of a transcription factor
Bioinformatics
December 2008
TEAD1 and c-Cbl are novel prostate basal cell markers that correlate with poor clinical...
British Journal of Cancer
November 2008
Biopsy tissue microarray study of Ki-67 expression in untreated, localized prostate can...
Prostate Cancer and Prostatic Diseases
September 2008
Expression profiling of CD133+and CD133-epithelial cells from human prostate
The Prostate
June 2008
Fitting ordinary differential equations to short time course data
Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering...
February 2008
Detection of TMPRSS2-ERG Translocations in Human Prostate Cancer by Expression Profilin...
Journal of Molecular Diagnostics
January 2008
AHR- and DNA-Damage-Mediated Gene Expression Responses Induced by Benzo(a)pyrene in Hum...
Chemical Research in Toxicology
December 2007
BMC Bioinformatics
January 2006
Genome Biology
January 2006
BMC Genomics
January 2006
Reconstructing gene networks: what are the limits?
Biochemical Society Transactions
December 2003
