Dr Daniel Brewer

University of East Anglia
Lecturer, Medicine And Medical Sciences
United Kingdom

My co-authors include

Professor Ming-Qing Du

Find me at

My Publications

Detecting new potential lines of attack against prostate cancer based on genetic inform...

Nature Genetics
April 2018

We obtained genetic information from the tumours of 112 men with prostate cancer and pooled it with data from other studies, together analysing samples from 930 prostate cancer patients. A detaile...

Study of mechanisms to "knock out" genes in prostate cancer

PLoS Genetics
September 2017

Cancer is a genetic disease where changes in DNA cause alterations in the control of cellular systems leading to unchecked growth. Copy number changes, including duplications, amplifications, and d...

DESNT: A Poor Prognosis Category of Human Prostate Cancer

European Urology Focus
March 2017

The evolutionary history of lethal metastatic prostate cancer

Nature
April 2015

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple ind...

Nature Genetics
March 2015

New prostate cancer urine test shows who needs treatment and when

BJU International
June 2019

We developed the Prostate Urine Risk (PUR) test using machine learning to look at gene expression in urine from samples collected from 537 men attending a clinic with suspected prostate cancer. By ...

Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and ...

Frontiers in Pharmacology
March 2019

epiCaPture: A Urine DNA Methylation Test for Early Detection of Aggressive Prostate Cancer

JCO Precision Oncology
January 2019

A urine-based DNA methylation assay, ProCUrE, to identify clinically significant prosta...

Clinical Epigenetics
November 2018

The landscape of viral associations in human cancers

November 2018

Mutational signatures of ionizing radiation in second malignancies

Nature Communications
September 2016

Prostate Single Nucleotide Polymorphism Provides a Crucial Clue to Cancer Aggression in...

European Urology
February 2016

Integration of copy number and transcriptomics provides risk stratification in prostate...

EBioMedicine
September 2015

Erratum: Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer i...

Nature Genetics
May 2015

Mutation detection in formalin-fixed prostate cancer biopsies taken at the time of diag...

Journal of Clinical Pathology
January 2015

HES5 silencing is an early and recurrent change in prostate tumourigenesis

January 2015

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

eLife
October 2014

A gene expression based predictor for high risk myeloma treated with intensive therapy ...

Leukemia & Lymphoma
August 2014

Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer...

Science
July 2014

Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer

British Journal of Cancer
January 2014

Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target ...

BMC Genomics
January 2014

Improved risk stratification in myeloma using a microRNA-based classifier

British Journal of Haematology
May 2013

Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer

British Journal of Cancer
May 2013

Prognostic value of blood mRNA expression signatures in castration-resistant prostate c...

The Lancet Oncology
November 2012

Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in pros...

Modern Pathology
August 2012

Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in pros...

Modern Pathology
March 2012

Modelling Transcription Factor Activity

September 2011

A Gene Expression-Based Predictor for Myeloma Patients at High Risk of Developing Bone ...

Clinical Cancer Research
August 2011

siRNA Knockdown of Ribosomal Protein Gene RPL19 Abrogates the Aggressive Phenotype of H...

PLoS ONE
July 2011

A HIF-Regulated VHL-PTP1B-Src Signaling Axis Identifies a Therapeutic Target in Renal C...

Science Translational Medicine
June 2011

PRKC- Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and ...

Genes & Cancer
May 2010

Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low a...

British Journal of Cancer
January 2010

A census of amplified and overexpressed human cancer genes

Nature Reviews Drug Discovery
January 2010

Dissection of a complex transcriptional response using genome-wide transcriptional mode...

Molecular Systems Biology
November 2009

Integration ofERGgene mapping and gene-expression profiling identifies distinct categor...

BJU International
May 2009

Interlaboratory and Interplatform Comparison of Microarray Gene Expression Analysis of ...

OMICS A Journal of Integrative Biology
April 2009

rHVDM: an R package to predict the activity and targets of a transcription factor

Bioinformatics
December 2008

TEAD1 and c-Cbl are novel prostate basal cell markers that correlate with poor clinical...

British Journal of Cancer
November 2008

Biopsy tissue microarray study of Ki-67 expression in untreated, localized prostate can...

Prostate Cancer and Prostatic Diseases
September 2008

Expression profiling of CD133+and CD133-epithelial cells from human prostate

The Prostate
June 2008

Fitting ordinary differential equations to short time course data

Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering...
February 2008

Detection of TMPRSS2-ERG Translocations in Human Prostate Cancer by Expression Profilin...

Journal of Molecular Diagnostics
January 2008

AHR- and DNA-Damage-Mediated Gene Expression Responses Induced by Benzo(a)pyrene in Hum...

Chemical Research in Toxicology
December 2007

BMC Bioinformatics
January 2006

Genome Biology
January 2006

BMC Genomics
January 2006

Reconstructing gene networks: what are the limits?

Biochemical Society Transactions
December 2003