What is it about?

In this study, we develop a test that can predict whether a patient has prostate cancer and how aggressive that cancer is. This test combines clinical measurements, levels of four genes collected from a fraction of the urine, and levels of six peptides found in urine. We found that this test, deemed ‘ExoSpec’, has the potential to improve the pathway for men with a clinical suspicion of prostate cancer and could reduce the requirement for biopsies by 30%.

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Why is it important?

Prostate cancer is one of the leading causes of cancer-related death in men in the world, but a large proportion of men that are diagnosed with prostate cancer do not have a form of the disease that will cause them long term harm. Therefore, there is a need to accurately predict the aggressiveness of the disease without taking an invasive biopsy.


This is the third in a series of three research articles that looks at combining different measurements from urine in prostate cancer to detect significant prostate cancer.

Professor Daniel S. Brewer
University of East Anglia

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This page is a summary of: A Model to Detect Significant Prostate Cancer Integrating Urinary Peptide and Extracellular Vesicle RNA Data, Cancers, April 2022, MDPI AG, DOI: 10.3390/cancers14081995.
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