What is it about?

Previously, our Prostate Urine Risk (PUR) test could identify men with high and low risk cancers - but can now help men with intermediate-risk disease - for whom treatment options had been less clear. This new research shows that the PUR test can be used to estimate the level of a specific pathological characteristic (Gleason Pattern 4) that is linked to increased risk of disease progression in men with prostate cancer.

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Why is it important?

This is important because, for men whose prostate tumour contains varying levels of Gleason Pattern 4, a prostate biopsy is necessary to determine whether men should receive active treatment or be managed by active surveillance.


In this research, we examine in more detail what biological change PUR is detecting. We found there is strong evidence that the PUR score is identifying the amount of a particular pattern of tumour cells there are in the prostate – this pattern is associated with aggresive disease

Professor Daniel S. Brewer
University of East Anglia

Read the Original

This page is a summary of: The Urine Biomarker PUR-4 Is Positively Associated with the Amount of Gleason 4 in Human Prostate Cancers, Life, November 2021, MDPI AG, DOI: 10.3390/life11111172.
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