All Stories

  1. Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice
  2. The Sedentary Lifestyle and Masticatory Dysfunction: Time to Review the Contribution to Age-Associated Cognitive Decline and Astrocyte Morphotypes in the Dentate Gyrus
  3. Assessing the effect of anesthetic gas mixtures on hyperpolarized 13 C pyruvate metabolism in the rat brain
  4. Reductive site-selective atypical C , Z -type/N2-C2 cleavage allows C-terminal protein amidation
  5. Predation Stress Causes Excessive Aggression in Female Mice with Partial Genetic Inactivation of Tryptophan Hydroxylase-2: Evidence for Altered Myelination-Related Processes
  6. Behavioral and Neuropathological Changes After Toxoplasma gondii Ocular Conjunctival Infection in BALB/c Mice
  7. Enhancing the microbiome provides long-term protection against inherited emotional dysfunction.
  8. Hippocampal Over-Expression of Cyclooxygenase-2 (COX-2) Is Associated with Susceptibility to Stress-Induced Anhedonia in Mice
  9. Rapid neutrophil mobilization by VCAM-1+ endothelial cell-derived extracellular vesicles
  10. Dimethyl fumarate decreases short-term but not long-term inflammation in a focal EAE model of neuroinflammation
  11. Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics
  12. Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illness
  13. Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
  14. In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo
  15. In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo
  16. Sex-Specific ADHD-like Behaviour, Altered Metabolic Functions, and Altered EEG Activity in Sialyltransferase ST3GAL5-Deficient Mice
  17. Contributing to Understand the Crosstalk between Brain and Periphery in Methylmercury Intoxication: Neurotoxicity and Extracellular Vesicles
  18. ASD-like behaviors, a dysregulated inflammatory response and decreased expression of PLP1 characterize mice deficient for sialyltransferase ST3GAL5
  19. Postnatal prebiotic supplementation in rats affects adult anxious behaviour, hippocampus, electrophysiology, metabolomics, and gut microbiota
  20. SPIKE-1: A Randomised Phase II/III trial in a community setting, assessing use of camostat in reducing the clinical progression of COVID-19 by blocking SARS-CoV-2 Spike protein-initiated membrane fusion
  21. Selective blood-brain barrier permeabilization of brain metastases by a type 1 receptor-selective tumor necrosis factor mutein
  22. Microglial Morphology Across Distantly Related Species: Phylogenetic, Environmental and Age Influences on Microglia Reactivity and Surveillance States
  23. Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illness
  24. Altered behaviour, dopamine and norepinephrine regulation in stressed mice heterozygous in TPH2 gene
  25. Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers
  26. Sedentary Life and Reduced Mastication Impair Spatial Learning and Memory and Differentially Affect Dentate Gyrus Astrocyte Subtypes in the Aged Mice
  27. Anti-CD20 Disrupts Meningeal B-Cell Aggregates in a Model of Secondary Progressive Multiple Sclerosis
  28. Acute IL-1RA treatment suppresses the peripheral and central inflammatory response to spinal cord injury
  29. Mom’s diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring
  30. Astroglia-specific contributions to the regulation of synapses, cognition and behaviour
  31. Post-inflammatory behavioural despair in male mice is associated with reduced cortical glutamate-glutamine ratios, and circulating lipid and energy metabolites
  32. Dibenzoylthiamine Has Powerful Antioxidant and Anti-Inflammatory Properties in Cultured Cells and in Mouse Models of Stress and Neurodegeneration
  33. A blood-based metabolomics test to distinguish relapsing–remitting and secondary progressive multiple sclerosis: addressing practical considerations for clinical application
  34. Stress-induced aggression in heterozygous TPH2 mutant mice is associated with alterations in serotonin turnover and expression of 5-HT6 and AMPA subunit 2A receptors
  35. Enhanced conditioning of adverse memories in the mouse modified swim test is associated with neuroinflammatory changes – Effects that are susceptible to antidepressants
  36. Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms
  37. A single administration of the antibiotic, minocycline, reduces fear processing and improves implicit learning in healthy volunteers: analysis of the serum metabolome
  38. Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner
  39. Metabolic, Molecular, and Behavioral Effects of Western Diet in Serotonin Transporter-Deficient Mice: Rescue by Heterozygosity?
  40. Metabolomics in multiple sclerosis disease course and progression
  41. Prefrontal cortex inflammation and liver pathologies accompany cognitive and motor deficits following Western diet consumption in non-obese female mice
  42. Systemic Immune Response to Traumatic CNS Injuries—Are Extracellular Vesicles the Missing Link?
  43. Extracellular vesicle integrins act as a nexus for platelet adhesion in cerebral microvessels
  44. TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex
  45. Classifying the antibody-negative NMO syndromes
  46. What Do Microglia Really Do in Healthy Adult Brain?
  47. Stereological Analysis of Early Gene Expression Using Egr-1 Immunolabeling After Spreading Depression in the Rat Somatosensory Cortex
  48. Thiamine and benfotiamine counteract ultrasound-induced aggression, normalize AMPA receptor expression and plasticity markers, and reduce oxidative stress in mice
  49. In vivo behaviour of glyco-NaI@SWCNT ‘nanobottles’
  50. Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation
  51. Prebiotic reduction of brain histone deacetylase (HDAC) activity and olanzapine-mediated weight gain in rats, are acetate independent
  52. Small-scale environmental enrichment and exercise enhance learning and spatial memory of Carassius auratus, and increase cell proliferation in the telencephalon: an exploratory study
  53. Effects of 50 Hz magnetic fields on circadian rhythm control in mice
  54. Neuroinflammation and aberrant hippocampal plasticity in a mouse model of emotional stress evoked by exposure to ultrasound of alternating frequencies
  55. Corrigendum: Early Growth Response Gene-2 Is Essential for M1 and M2 Macrophage Activation and Plasticity by Modulation of the Transcription Factor CEBPβ
  56. Early Growth Response Gene-2 Is Essential for M1 and M2 Macrophage Activation and Plasticity by Modulation of the Transcription Factor CEBPβ
  57. Platelets mediate protective neuroinflammation and promote neuronal plasticity at the site of neuronal injury
  58. The subtleties of cognitive decline in multiple sclerosis,
  59. Plasma Nuclear Magnetic Resonance Metabolomics Discriminates Between High and Low Endoscopic Activity and Predicts Progression in a Prospective Cohort of Patients With Ulcerative Colitis
  60. Prebiotic attenuation of olanzapine-induced weight gain in rats: analysis of central and peripheral biomarkers and gut microbiota
  61. Hepatic acute phase response protects the brain from focal inflammation during postnatal window of susceptibility
  62. Exacerbation of Acute Traumatic Brain Injury by Circulating Extracellular Vesicles
  63. Increased cortical neuronal responses to NMDA and improved attentional set-shifting performance in rats following prebiotic (B-GOS®) ingestion
  64. Metabolomics reveals distinct, antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease
  65. The contribution of the acute phase response to the pathogenesis of relapse in chronic-relapsing experimental autoimmune encephalitis models of multiple sclerosis
  66. Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction
  67. Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation
  68. Erratum to: The role of PPAR activation during the systemic response to brain injury
  69. Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels
  70. Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions
  71. Thiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stress-induced behaviours in mice
  72. Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI
  73. Interleukin-6 is increased in plasma and cerebrospinal fluid of community-dwelling domestic dogs with acute ischaemic stroke
  74. Age and Environment Influences on Mouse Prion Disease Progression: Behavioral Changes and Morphometry and Stereology of Hippocampal Astrocytes
  75. Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice
  76. Carbon nanotubes allow capture of krypton, barium and lead for multichannel biological X-ray fluorescence imaging
  77. Age, environment, object recognition and morphological diversity of GFAP-immunolabeled astrocytes
  78. Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice
  79. Hierarchical Cluster Analysis of Three-Dimensional Reconstructions of Unbiased Sampled Microglia Shows not Continuous Morphological Changes from Stage 1 to 2 after Multiple Dengue Infections in Callithrix penicillata
  80. Prebiotic administration normalizes lipopolysaccharide (LPS)-induced anxiety and cortical 5-HT2A receptor and IL1-β levels in male mice
  81. Neonatal prebiotic (BGOS) supplementation increases the levels of synaptophysin, GluN2A-subunits and BDNF proteins in the adult rat hippocampus
  82. Early Diagnosis of Brain Metastases Using a Biofluids-Metabolomics Approach in Mice
  83. The effect of B-cell depletion in the Theiler's model of multiple sclerosis
  84. Antibody-enhanced dengue disease generates a marked CNS inflammatory response in the black-tufted marmosetCallithrix penicillata
  85. Beneficial effects of multisensory and cognitive stimulation in institutionalized elderly: 12-months follow-up
  86. Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet
  87. NMR-Based Metabolomics Separates the Distinct Stages of Disease in a Chronic Relapsing Model of Multiple Sclerosis
  88. A Model of Post-Infection Fatigue Is Associated with Increased TNF and 5-HT2A Receptor Expression in Mice
  89. The role of PPAR activation during the systemic response to brain injury
  90. Cerebrospinal fluid metabolomics implicate bioenergetic adaptation as a neural mechanism regulating shifts in cognitive states of HIV-infected patients
  91. In Vivo PET Imaging Demonstrates Diminished Microglial Activation After Fingolimod Treatment in an Animal Model of Multiple Sclerosis
  92. Deuterium content of water increases depression susceptibility: The potential role of a serotonin-related mechanism
  93. Endotoxaemia resulting from decreased serotonin tranporter (5-HTT) function: A reciprocal risk factor for depression and insulin resistance?
  94. Lasting downregulation of the lipid peroxidation enzymes in the prefrontal cortex of mice susceptible to stress-induced anhedonia
  95. Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia
  96. Viral pre-challenge increases central nervous system inflammation after intracranial interleukin-1β injection
  97. A type 2 biomarker separates relapsing-remitting from secondary progressive multiple sclerosis
  98. Anti‐CD20 inhibits T cell‐mediated pathology and microgliosis in the rat brain
  99. The systemic response to CNS injury
  100. Creation of a gated antibody as a conditionally functional synthetic protein
  101. Corrigendum to “Systemic inflammation alters central 5-HT function as determined by pharmacological MRI” [Neuroimage 75 (2013) 177–186]
  102. CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis
  103. The role of hemorrhage following spinal-cord injury
  104. Investigation of immune and CNS-mediated effects of fingolimod in the focal delayed-type hypersensitivity multiple sclerosis model
  105. Detection of Microglial Activation in an Acute Model of Neuroinflammation Using PET and Radiotracers 11C-(R)-PK11195 and 18F-GE-180
  106. T2-Weighted MRI Detects Presymptomatic Pathology in the SOD1 Mouse Model of ALS
  107. Corrigendum to “Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia” [Brain, Behavior, and Immunity 29 (2013) 136–146]
  108. Glial Activation in the Early Stages of Brain Metastasis: TSPO as a Diagnostic Biomarker
  109. Impact of vasculature damage to the outcome of spinal cord injury: a new collagenase-induced model may give new insights into the mechanisms involved
  110. Functional role of endothelial adhesion molecules in the early stages of brain metastasis
  111. Selective Permeabilization of the Blood–Brain Barrier at Sites of Metastasis
  112. The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock
  113. Systemic inflammation alters central 5-HT function as determined by pharmacological MRI
  114. Anti–IL-17A Treatment Reduces Clinical Score and VCAM-1 Expression Detected by in Vivo Magnetic Resonance Imaging in Chronic Relapsing EAE ABH Mice
  115. Reducing suffering in experimental autoimmune encephalomyelitis (EAE)
  116. The differential effects of chronic imipramine or citalopram administration on physiological and behavioral outcomes in naïve mice
  117. Obesity and statins are both independent predictors of enhanced coronary arteriolar dilation in patients undergoing heart surgery
  118. Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia
  119. Special issue commentary: The changing face of inflammation in the brain
  120. Magnetic Resonance Imaging Reveals Therapeutic Effects of Interferon-Beta on Cytokine-Induced Reactivation of Rat Model of Multiple Sclerosis
  121. Reducing suffering in animal models and procedures involving seizures, convulsions and epilepsy
  122. The systemic response to brain injury and disease
  123. Imaging seizure-induced inflammation using an antibody targeted iron oxide contrast agent
  124. Molecular MRI enables early and sensitive detection of brain metastases
  125. Selenenylsulfide-Linked Homogeneous Glycopeptides and Glycoproteins: Synthesis of Human “Hepatic Se Metabolite A”
  126. The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation
  127. Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse
  128. VCAM-1-targeted magnetic resonance imaging reveals subclinical disease in a mouse model of multiple sclerosis
  129. Neurofilament heavy chain in CSF correlates with relapses and disability in multiple sclerosis
  130. Molecular MRI Approaches to the Detection of CNS Inflammation
  131. Detection of Brain Pathology by Magnetic Resonance Imaging of Iron Oxide Micro-particles
  132. Magnetic Resonance Imaging of Brain Inflammation Using Microparticles of Iron Oxide
  133. Sickness behaviour is induced by a peripheral CXC-chemokine also expressed in Multiple Sclerosis and EAE
  134. NEUROBID—an EU‐funded project to study the developing brain barriers
  135. Molecular Magnetic Resonance Imaging of Acute Vascular Cell Adhesion Molecule-1 Expression in a Mouse Model of Cerebral Ischemia
  136. Potent Fluoro-oligosaccharide Probes of Adhesion inToxoplasmosis
  137. Systemic Inflammatory Response Reactivates Immune-Mediated Lesions in Rat Brain
  138. Correction for van Kasteren et al., Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease
  139. Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease
  140. Comparison of MRI signatures in pattern I and II multiple sclerosis models
  141. Inhibition of peripheral TNF can block the malaise associated with CNS inflammatory diseases
  142. Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord
  143. Hepatic Nuclear Factor κB Regulates Neutrophil Recruitment to the Injured Brain
  144. Acute Astrocyte Activation in Brain Detected by MRI: New Insights into T1 Hypointensity
  145. A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI
  146. Inflammatory responses in the rat brain in response to different methods of intra-cerebral administration
  147. Immunomodulatory effects of etanercept in a model of brain injury act through attenuation of the acute-phase response
  148. In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide
  149. Acute Astrocyte Activation in Brain Detected by Mri: New Insights into T1 Hypointensity
  150. Overexpression of IL-1β by adenoviral-mediated gene transfer in the rat brain causes a prolonged hepatic chemokine response, axonal injury and the suppression of spontaneous behaviour
  151. MRI and MRS alterations in the preclinical phase of murine prion disease: Association with neuropathological and behavioural changes
  152. Expanding the diversity of chemical protein modification allows post-translational mimicry
  153. Loss of the atypical inflammatory response in juvenile and aged rats
  154. Post-conditioning with lipopolysaccharide reduces the inflammatory infiltrate to the injured brain and spinal cord: a potential neuroprotective treatment
  155. Detection of the inhibitory neurotransmitter GABA in macrophages by magnetic resonance spectroscopy
  156. Central Nervous System Injury Triggers Hepatic CC and CXC Chemokine Expression that Is Associated with Leukocyte Mobilization and Recruitment to Both the Central Nervous System and the Liver
  157. Differential regulation of type I and type II interleukin-1 receptors in focal brain inflammation
  158. MRI Reveals That Early Changes in Cerebral Blood Volume Precede Blood–Brain Barrier Breakdown and Overt Pathology in MS-like Lesions in Rat Brain
  159. The Murine Cyp1a1 Gene Is Expressed in a Restricted Spatial and Temporal Pattern during Embryonic Development
  160. Reversible Demyelination, Blood-Brain Barrier Breakdown, and Pronounced Neutrophil Recruitment Induced by Chronic IL-1 Expression in the Brain
  161. Anti-inflammatory modulators in stroke
  162. Study of cytokine induced neuropathology by high resolution proton NMR spectroscopy of rat urine
  163. Reduction of excitotoxicity and associated leukocyte recruitment by a broad‐spectrum matrix metalloproteinase inhibitor
  164. Targeting Experimental Autoimmune Encephalomyelitis Lesions to a Predetermined Axonal Tract System Allows for Refined Behavioral Testing in an Animal Model of Multiple Sclerosis
  165. Learning modulation by endogenous hippocampal IL-1: Blockade of endogenous IL-1 facilitates memory formation
  166. MRI detection of early endothelial activation in brain inflammation
  167. Focal Lesions in the Rat Central Nervous System Induced by Endothelin-1
  168. Effect of methylprednisolone on the ulceration, matrix metalloproteinase distribution and eicosanoid production in a model of colitis in the rabbit
  169. CINC-1 is identified as an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury
  170. Differential induction of interleukin-1β and tumour necrosis factor-α may account for specific patterns of leukocyte recruitment in the brain
  171. TNF-alpha reduces cerebral blood volume and disrupts tissue homeostasis via an endothelin- and TNFR2-dependent pathway
  172. Altered chemokine expression in the spinal cord and brain contributes to differential interleukin-1β-induced neutrophil recruitment
  173. Inflammatory Cytokines, Angiogenesis, and Fibrosis in the Rat Peritoneum
  174. The Systemic and Local Acute Phase Response following Acute Brain Injury
  175. T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases
  176. Recruitment of Neutrophils across the Blood–Brain Barrier: The Role of E- and P-selectins
  177. Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis
  178. Interleukin-1β exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures
  179. Chemokine targets in acute brain injury and disease
  180. Interleukin-1β-Induced Changes in Blood–Brain Barrier Permeability, Apparent Diffusion Coefficient, and Cerebral Blood Volume in the Rat Brain: A Magnetic Resonance Study
  181. Axon damage and repair in multiple sclerosis
  182. The therapeutic potential of CXC chemokine blockade in acute inflammation in the brain
  183. The contribution of inflammation to acute and chronic neurodegeneration
  184. Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS
  185. CXC chemokines generate age-related increases in neutrophil-mediated brain inflammation and blood–brain barrier breakdown
  186. Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood–brain barrier breakdown in vivo
  187. Stroke: A double-edged sword for cleaving clots?
  188. Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke
  189. Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke
  190. The blood-brain barrier and the inflammatory response
  191. Age-related effects of interleukin-1 beta on polymorphonuclear neutrophil-dependent increases in blood-brain barrier permeability in rats
  192. Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview
  193. Protease expression in experimental colitis
  194. Modulation of human neutrophil function by fibronectin degradation products isolated from cryoglobulins