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  1. Hepatic iron accumulation is reduced in the cholestatic Mdr2−/− mouse
  2. Ferroportin at the Crossroads of Iron Biology: Disease, Regulation and Modulation
  3. Loss of peroxisomal membrane proteins PEX13 and PEX14 disrupts fatty acid oxidation and drives lipid imbalance
  4. Tfr2 is necessary for acute iron-dependent hepcidin induction in mice with Tfr1-deficient hepatocytes
  5. Mechanisms of liver regeneration and their relevance to steatotic liver disease
  6. Peroxisome Dysfunction and Steatotic Liver Disease
  7. A novel human hepatocyte cell line to study PNPLA3-associated steatotic liver disease
  8. Three-Dimensional Dynamic Cell Models for Metabolic Dysfunction-Associated Steatotic Liver Disease Progression
  9. Effects of iron overload in human joint tissue explant cultures and animal models
  10. A new form of hereditary iron overload unlinked to known hereditary haemochromatosis genes
  11. Gene Variants Implicated in Steatotic Liver Disease: Opportunities for Diagnostics and Therapeutics
  12. Engineering Peptide Inhibitors of the HFE–Transferrin Receptor 1 Complex
  13. Cancer: The role of iron and ferroptosis
  14. Genetic Diagnosis in Hereditary Hemochromatosis: Discovering and Understanding the Biological Relevance of Variants
  15. The effect of the flavonol rutin on serum and liver iron content in a genetic mouse model of iron overload
  16. Iron depletion attenuates steatosis in a mouse model of non-alcoholic fatty liver disease: Role of iron-dependent pathways
  17. In vitro identification and characterisation of iron chelating catechol-containing natural products and derivatives
  18. Biology of the iron efflux transporter, ferroportin
  19. Gender biased neuroprotective effect of Transferrin Receptor 2 deletion in multiple models of Parkinson’s disease
  20. Increased frequency of GNPAT p.D519G in compound HFE p.C282Y/p.H63D heterozygotes with elevated serum ferritin levels
  21. Hepatocyte-specific deletion of peroxisomal protein PEX13 results in disrupted iron homeostasis
  22. Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression
  23. Evidence for dimerization of ferroportin in a human hepatic cell line using proximity ligation assays
  24. Correction to: The potential prognostic utility of salivary galectin-3 concentrations in heart failure
  25. Therapeutic Advances in Regulating the Hepcidin/Ferroportin Axis
  26. The potential prognostic utility of salivary galectin-3 concentrations in heart failure
  27. Signaling pathways regulating hepcidin
  28. Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes
  29. Hemochromatosis: Evaluation of the dietary iron model and regulation of hepcidin
  30. Phenotypic analysis of hemochromatosis subtypes reveals variations in severity of iron overload and clinical disease
  31. Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease
  32. Evaluation of a bone morphogenetic protein 6 variant as a cause of iron loading
  33. Reversal of end-stage heart failure in juvenile hemochromatosis with iron chelation therapy: a case report
  34. Ferroportin Expression in Adipocytes Does Not Contribute to Iron Homeostasis or Metabolic Responses to a High Calorie Diet
  35. Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes
  36. The relationship between systemic iron homeostasis and erythropoiesis
  37. The liver in regulation of iron homeostasis
  38. The dynamics of hepcidin-ferroportin internalization and consequences of a novel ferroportin disease mutation
  39. GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes
  40. Reply:
  41. Ironing out Steatohepatitis
  42. Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice
  43. The functional roles of T-cadherin in mammalian biology
  44. Genetic Variants in the BMP6 Pro-Peptide May Not Cause Iron Loading and Should Be Interpreted With Caution
  45. Pocket-sized iron regulators: one size fits all?
  46. Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron-deficient anemia
  47. Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high-calorie diet
  48. Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease
  49. Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics
  50. Reply
  51. Iron and non-alcoholic fatty liver disease
  52. Reply
  53. The global prevalence of HFE and non-HFE hemochromatosis estimated from analysis of next-generation sequencing data
  54. Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2
  55. Next-generation sequencing: Application of a novel platform to analyze atypical iron disorders
  56. Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin
  57. Reply
  58. Hepcidin: regulation of the master iron regulator
  59. Exome sequencing inHFEC282Y homozygous men with extreme phenotypes identifies aGNPATvariant associated with severe iron overload
  60. Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox
  61. Functional analysis of matriptase-2 mutations and domains: insights into the molecular basis of iron-refractory iron deficiency anemia
  62. Analysis of IL-22 contribution to hepcidin induction and hypoferremia during the response to LPS in vivo
  63. A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction
  64. Hepatology Clinical
  65. IBD Clinical
  66. Luminal Clinical
  67. Linking hypoxia and iron homeostasis: a ‘plate’ full of factors
  68. Lack of efficacy of mTOR inhibitors and ACE pathway inhibitors as antifibrotic agents in evolving and established fibrosis in Mdr2 −/− mice
  69. Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB
  70. Parenteral vs. oral iron: influence on hepcidin signaling pathways through analysis of Hfe/Tfr2-null mice
  71. Inside Li
  72. Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury
  73. In Situ Proximity Ligation Assays Indicate That Hemochromatosis Proteins Hfe and Transferrin Receptor 2 (Tfr2) Do Not Interact
  74. IBD Clinical
  75. Luminal Clinical
  76. Author Index
  77. Basic Science Luminal
  78. Motility/Neurogastroenterology
  79. Transthyretin-thyroid hormone internalization by trophoblasts
  80. Iron storage disease in Asia-Pacific populations: The importance of non-HFEmutations
  81. A Corn Oil-Based Diet Protects Against Combined Ethanol and Iron-Induced Liver Injury in a Mouse Model of Hemochromatosis
  82. Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment
  83. Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis
  84. Hepatic Iron Deposition Does Not Predict Extrahepatic Iron Loading in Mouse Models of Hereditary Hemochromatosis
  85. Iron Predicts Tolerance in Liver Transplantation
  86. A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity
  87. Non-HFE Hemochromatosis
  88. The Control of Iron Homeostasis: microRNAS Join the Party
  89. Altered lipid metabolism in Hfe-knockout mice promotes severe NAFLD and early fibrosis
  90. G80S-linked ferroportin disease: Classical ferroportin disease in an Asian family and reclassification of the mutant as iron transport defective
  91. Iron loading and oxidative stress in the Atm-/- mouse liver
  92. Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2
  93. Syntaxin 5 Is Required for Copper Homeostasis in Drosophila and Mammals
  94. Transferrin Receptor 1: A Ferritin Receptor as Well?
  95. Increased Iron Stores Correlate with Worse Disease Outcomes in a Mouse Model of Schistosomiasis Infection
  96. Centrobin regulates the assembly of functional mitotic spindles
  97. Identification of Ferritin Receptors: Their Role in Iron Homeostasis, Hepatic Injury, and Inflammation
  98. Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype
  99. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
  100. Hepcidin Regulation by HFE and TFR2: Is It Enough to Give a Hepatocyte a Complex?
  101. Co-factors in liver disease: The role of HFE-related hereditary hemochromatosis and iron
  102. Carrier-Mediated Thyroid Hormone Transport into Placenta by Placental Transthyretin
  103. Regulation of Iron Homeostasis: Is It All in the HBD?
  104. Juvenile iron overload—Advances, but no answers
  105. Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis
  106. Lymphotoxin-β receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury
  107. Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression
  108. How much iron is too much?
  109. Defective trafficking and localization of mutated transferrin receptor 2: implications for type 3 hereditary hemochromatosis
  110. A novel mutation in ferroportin implicated in iron overload
  111. [119] TARGETED DISRUPTION OF THE HEPATIC TRANSFERRIN RECEPTOR 2 GENE IN MICE LEADS TO IRON OVERLOAD
  112. Targeted Disruption of the Hepatic Transferrin Receptor 2 Gene in Mice Leads to Iron Overload
  113. Non-HFE haemochromatosis
  114. The Clinical Relevance of Compound Heterozygosity for the C282Y and H63D Substitutions in Hemochromatosis
  115. Clinical expression of C282Y homozygous HFE haemochromatosis at 14 years of age
  116. Screening for Hemochromatosis in Asymptomatic Subjects With or Without a Family History
  117. Purification and partial characterisation of recombinant human hepcidin
  118. Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes
  119. Ferroportin disease due to the A77D mutation in Australia
  120. First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
  121. Identification of ferroportin disease in the Indian subcontinent
  122. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus
  123. HFE gene and hemochromatosis
  124. Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosis
  125. Reply
  126. Inactivation of the murineTransferrin Receptor 2 gene using the Cre recombinase:LoxP system
  127. Ironing out doxorubicin-related cardiotoxicity
  128. A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient
  129. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
  130. Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis
  131. Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282Y
  132. Molecular and Cellular Characterization of Transferrin Receptor 2
  133. Role of p97 and Syntaxin 5 in the Assembly of Transitional Endoplasmic Reticulum
  134. Haemochromatosis in the new millenium
  135. cDNA Characterization and Chromosomal Mapping of Human Golgi SNARE GS27 and GS28 to Chromosome 17
  136. GS32, a Novel Golgi SNARE of 32 kDa, Interacts Preferentially with Syntaxin 6
  137. A Novel Synaptobrevin/VAMP Homologous Protein (VAMP5) Is Increased during In Vitro Myogenesis and Present in the Plasma Membrane
  138. A 29-Kilodalton Golgi SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Vti1-rp2) Implicated in Protein Trafficking in the Secretory Pathway
  139. Endobrevin, a Novel Synaptobrevin/VAMP-Like Protein Preferentially Associated with the Early Endosome
  140. The Mammalian Protein (rbet1) Homologous to Yeast Bet1p Is Primarily Associated with the Pre-Golgi Intermediate Compartment and Is Involved in Vesicular Transport from the Endoplasmic Reticulum to the Golgi Apparatus
  141. N-Ethylmaleimide-sensitive Factor (NSF) and  -Soluble NSF Attachment Proteins (SNAP) Mediate Dissociation of GS28-Syntaxin 5 Golgi SNAP Receptors (SNARE) Complex
  142. GS15, a 15-Kilodalton Golgi SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (SNARE) Homologous to rbet1
  143. GS28, a 28-Kilodalton Golgi SNARE That Participates in ER-Golgi Transport
  144. cDNA Cloning and Characterization of Rat Salivary Glycoproteins. Novel Members of the Proline-Rich-Protein Multigene Families
  145. cDNA Cloning and Characterization of Rat Salivary Glycoproteins. Novel Members of the Proline-Rich-Protein Multigene Families
  146. cDNA Cloning and Characterization of Rat Salivary Glycoproteins. Novel Members of the Proline-Rich-Protein Multigene Families