All Stories

  1. Loss of peroxisomal membrane proteins PEX13 and PEX14 disrupts fatty acid oxidation and drives lipid imbalance
  2. Tfr2 is necessary for acute iron-dependent hepcidin induction in mice with Tfr1-deficient hepatocytes
  3. Mechanisms of liver regeneration and their relevance to steatotic liver disease
  4. Peroxisome Dysfunction and Steatotic Liver Disease
  5. A novel human hepatocyte cell line to study PNPLA3-associated steatotic liver disease
  6. Three-Dimensional Dynamic Cell Models for Metabolic Dysfunction-Associated Steatotic Liver Disease Progression
  7. Effects of iron overload in human joint tissue explant cultures and animal models
  8. A new form of hereditary iron overload unlinked to known hereditary haemochromatosis genes
  9. Gene Variants Implicated in Steatotic Liver Disease: Opportunities for Diagnostics and Therapeutics
  10. Engineering Peptide Inhibitors of the HFE–Transferrin Receptor 1 Complex
  11. Cancer: The role of iron and ferroptosis
  12. Genetic Diagnosis in Hereditary Hemochromatosis: Discovering and Understanding the Biological Relevance of Variants
  13. The effect of the flavonol rutin on serum and liver iron content in a genetic mouse model of iron overload
  14. Iron depletion attenuates steatosis in a mouse model of non-alcoholic fatty liver disease: Role of iron-dependent pathways
  15. In vitro identification and characterisation of iron chelating catechol-containing natural products and derivatives
  16. Biology of the iron efflux transporter, ferroportin
  17. Gender biased neuroprotective effect of Transferrin Receptor 2 deletion in multiple models of Parkinson’s disease
  18. Increased frequency of GNPAT p.D519G in compound HFE p.C282Y/p.H63D heterozygotes with elevated serum ferritin levels
  19. Hepatocyte-specific deletion of peroxisomal protein PEX13 results in disrupted iron homeostasis
  20. Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression
  21. Evidence for dimerization of ferroportin in a human hepatic cell line using proximity ligation assays
  22. Correction to: The potential prognostic utility of salivary galectin-3 concentrations in heart failure
  23. Therapeutic Advances in Regulating the Hepcidin/Ferroportin Axis
  24. The potential prognostic utility of salivary galectin-3 concentrations in heart failure
  25. Signaling pathways regulating hepcidin
  26. Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes
  27. Hemochromatosis: Evaluation of the dietary iron model and regulation of hepcidin
  28. Phenotypic analysis of hemochromatosis subtypes reveals variations in severity of iron overload and clinical disease
  29. Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease
  30. Evaluation of a bone morphogenetic protein 6 variant as a cause of iron loading
  31. Reversal of end-stage heart failure in juvenile hemochromatosis with iron chelation therapy: a case report
  32. Ferroportin Expression in Adipocytes Does Not Contribute to Iron Homeostasis or Metabolic Responses to a High Calorie Diet
  33. Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes
  34. The relationship between systemic iron homeostasis and erythropoiesis
  35. The liver in regulation of iron homeostasis
  36. The dynamics of hepcidin-ferroportin internalization and consequences of a novel ferroportin disease mutation
  37. GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes
  38. Reply:
  39. Ironing out Steatohepatitis
  40. Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice
  41. The functional roles of T-cadherin in mammalian biology
  42. Genetic Variants in the BMP6 Pro-Peptide May Not Cause Iron Loading and Should Be Interpreted With Caution
  43. Pocket-sized iron regulators: one size fits all?
  44. Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron-deficient anemia
  45. Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high-calorie diet
  46. Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease
  47. Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics
  48. Reply
  49. Iron and non-alcoholic fatty liver disease
  50. Reply
  51. The global prevalence of HFE and non-HFE hemochromatosis estimated from analysis of next-generation sequencing data
  52. Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2
  53. Next-generation sequencing: Application of a novel platform to analyze atypical iron disorders
  54. Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin
  55. Reply
  56. Hepcidin: regulation of the master iron regulator
  57. Exome sequencing inHFEC282Y homozygous men with extreme phenotypes identifies aGNPATvariant associated with severe iron overload
  58. Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox
  59. Functional analysis of matriptase-2 mutations and domains: insights into the molecular basis of iron-refractory iron deficiency anemia
  60. Analysis of IL-22 contribution to hepcidin induction and hypoferremia during the response to LPS in vivo
  61. A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction
  62. Hepatology Clinical
  63. IBD Clinical
  64. Luminal Clinical
  65. Linking hypoxia and iron homeostasis: a ‘plate’ full of factors
  66. Lack of efficacy of mTOR inhibitors and ACE pathway inhibitors as antifibrotic agents in evolving and established fibrosis in Mdr2 −/− mice
  67. Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB
  68. Parenteral vs. oral iron: influence on hepcidin signaling pathways through analysis of Hfe/Tfr2-null mice
  69. Inside Li
  70. Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury
  71. In Situ Proximity Ligation Assays Indicate That Hemochromatosis Proteins Hfe and Transferrin Receptor 2 (Tfr2) Do Not Interact
  72. IBD Clinical
  73. Luminal Clinical
  74. Author Index
  75. Basic Science Luminal
  76. Motility/Neurogastroenterology
  77. Transthyretin-thyroid hormone internalization by trophoblasts
  78. Iron storage disease in Asia-Pacific populations: The importance of non-HFEmutations
  79. A Corn Oil-Based Diet Protects Against Combined Ethanol and Iron-Induced Liver Injury in a Mouse Model of Hemochromatosis
  80. Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment
  81. Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis
  82. Hepatic Iron Deposition Does Not Predict Extrahepatic Iron Loading in Mouse Models of Hereditary Hemochromatosis
  83. Iron Predicts Tolerance in Liver Transplantation
  84. A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity
  85. Non-HFE Hemochromatosis
  86. The Control of Iron Homeostasis: microRNAS Join the Party
  87. Altered lipid metabolism in Hfe-knockout mice promotes severe NAFLD and early fibrosis
  88. G80S-linked ferroportin disease: Classical ferroportin disease in an Asian family and reclassification of the mutant as iron transport defective
  89. Iron loading and oxidative stress in the Atm-/- mouse liver
  90. Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2
  91. Syntaxin 5 Is Required for Copper Homeostasis in Drosophila and Mammals
  92. Transferrin Receptor 1: A Ferritin Receptor as Well?
  93. Increased Iron Stores Correlate with Worse Disease Outcomes in a Mouse Model of Schistosomiasis Infection
  94. Centrobin regulates the assembly of functional mitotic spindles
  95. Identification of Ferritin Receptors: Their Role in Iron Homeostasis, Hepatic Injury, and Inflammation
  96. Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype
  97. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
  98. Hepcidin Regulation by HFE and TFR2: Is It Enough to Give a Hepatocyte a Complex?
  99. Co-factors in liver disease: The role of HFE-related hereditary hemochromatosis and iron
  100. Carrier-Mediated Thyroid Hormone Transport into Placenta by Placental Transthyretin
  101. Regulation of Iron Homeostasis: Is It All in the HBD?
  102. Juvenile iron overload—Advances, but no answers
  103. Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis
  104. Lymphotoxin-β receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury
  105. Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression
  106. How much iron is too much?
  107. Defective trafficking and localization of mutated transferrin receptor 2: implications for type 3 hereditary hemochromatosis
  108. A novel mutation in ferroportin implicated in iron overload
  109. [119] TARGETED DISRUPTION OF THE HEPATIC TRANSFERRIN RECEPTOR 2 GENE IN MICE LEADS TO IRON OVERLOAD
  110. Targeted Disruption of the Hepatic Transferrin Receptor 2 Gene in Mice Leads to Iron Overload
  111. Non-HFE haemochromatosis
  112. The Clinical Relevance of Compound Heterozygosity for the C282Y and H63D Substitutions in Hemochromatosis
  113. Clinical expression of C282Y homozygous HFE haemochromatosis at 14 years of age
  114. Screening for Hemochromatosis in Asymptomatic Subjects With or Without a Family History
  115. Purification and partial characterisation of recombinant human hepcidin
  116. Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes
  117. Ferroportin disease due to the A77D mutation in Australia
  118. First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
  119. Identification of ferroportin disease in the Indian subcontinent
  120. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus
  121. HFE gene and hemochromatosis
  122. Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosis
  123. Reply
  124. Inactivation of the murineTransferrin Receptor 2 gene using the Cre recombinase:LoxP system
  125. Ironing out doxorubicin-related cardiotoxicity
  126. A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient
  127. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
  128. Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis
  129. Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282Y
  130. Molecular and Cellular Characterization of Transferrin Receptor 2
  131. Role of p97 and Syntaxin 5 in the Assembly of Transitional Endoplasmic Reticulum
  132. Haemochromatosis in the new millenium
  133. cDNA Characterization and Chromosomal Mapping of Human Golgi SNARE GS27 and GS28 to Chromosome 17
  134. GS32, a Novel Golgi SNARE of 32 kDa, Interacts Preferentially with Syntaxin 6
  135. A Novel Synaptobrevin/VAMP Homologous Protein (VAMP5) Is Increased during In Vitro Myogenesis and Present in the Plasma Membrane
  136. A 29-Kilodalton Golgi SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Vti1-rp2) Implicated in Protein Trafficking in the Secretory Pathway
  137. Endobrevin, a Novel Synaptobrevin/VAMP-Like Protein Preferentially Associated with the Early Endosome
  138. The Mammalian Protein (rbet1) Homologous to Yeast Bet1p Is Primarily Associated with the Pre-Golgi Intermediate Compartment and Is Involved in Vesicular Transport from the Endoplasmic Reticulum to the Golgi Apparatus
  139. N-Ethylmaleimide-sensitive Factor (NSF) and  -Soluble NSF Attachment Proteins (SNAP) Mediate Dissociation of GS28-Syntaxin 5 Golgi SNAP Receptors (SNARE) Complex
  140. GS15, a 15-Kilodalton Golgi SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (SNARE) Homologous to rbet1
  141. GS28, a 28-Kilodalton Golgi SNARE That Participates in ER-Golgi Transport
  142. cDNA Cloning and Characterization of Rat Salivary Glycoproteins. Novel Members of the Proline-Rich-Protein Multigene Families
  143. cDNA Cloning and Characterization of Rat Salivary Glycoproteins. Novel Members of the Proline-Rich-Protein Multigene Families
  144. cDNA Cloning and Characterization of Rat Salivary Glycoproteins. Novel Members of the Proline-Rich-Protein Multigene Families