All Stories

  1. Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes
  2. Hemochromatosis: Evaluation of the dietary iron model and regulation of hepcidin
  3. Phenotypic analysis of hemochromatosis subtypes reveals variations in severity of iron overload and clinical disease
  4. Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease
  5. Evaluation of a bone morphogenetic protein 6 variant as a cause of iron loading
  6. Reversal of end-stage heart failure in juvenile hemochromatosis with iron chelation therapy: a case report
  7. Ferroportin Expression in Adipocytes Does Not Contribute to Iron Homeostasis or Metabolic Responses to a High Calorie Diet
  8. Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes
  9. The relationship between systemic iron homeostasis and erythropoiesis
  10. The liver in regulation of iron homeostasis
  11. The dynamics of hepcidin-ferroportin internalization and consequences of a novel ferroportin disease mutation
  12. GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes
  13. Reply:
  14. Ironing out Steatohepatitis
  15. Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice
  16. The functional roles of T-cadherin in mammalian biology
  17. Genetic Variants in the BMP6 Pro-Peptide May Not Cause Iron Loading and Should Be Interpreted With Caution
  18. Pocket-sized iron regulators: one size fits all?
  19. Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron-deficient anemia
  20. Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high-calorie diet
  21. Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease
  22. Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics
  23. Reply
  24. Iron and non-alcoholic fatty liver disease
  25. Reply
  26. The global prevalence of HFE and non-HFE hemochromatosis estimated from analysis of next-generation sequencing data
  27. Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2
  28. Next-generation sequencing: Application of a novel platform to analyze atypical iron disorders
  29. Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin
  30. Reply
  31. Hepcidin: regulation of the master iron regulator
  32. Exome sequencing inHFEC282Y homozygous men with extreme phenotypes identifies aGNPATvariant associated with severe iron overload
  33. Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox
  34. Functional analysis of matriptase-2 mutations and domains: insights into the molecular basis of iron-refractory iron deficiency anemia
  35. Analysis of IL-22 contribution to hepcidin induction and hypoferremia during the response to LPS in vivo
  36. A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction
  37. Hepatology Clinical
  38. IBD Clinical
  39. Luminal Clinical
  40. Linking hypoxia and iron homeostasis: a ‘plate’ full of factors
  41. Lack of efficacy of mTOR inhibitors and ACE pathway inhibitors as antifibrotic agents in evolving and established fibrosis in Mdr2 −/− mice
  42. Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB
  43. Parenteral vs. oral iron: influence on hepcidin signaling pathways through analysis of Hfe/Tfr2-null mice
  44. Inside Li
  45. Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury
  46. In Situ Proximity Ligation Assays Indicate That Hemochromatosis Proteins Hfe and Transferrin Receptor 2 (Tfr2) Do Not Interact
  47. IBD Clinical
  48. Luminal Clinical
  49. Author Index
  50. Basic Science Luminal
  51. Motility/Neurogastroenterology
  52. Transthyretin-thyroid hormone internalization by trophoblasts
  53. Iron storage disease in Asia-Pacific populations: The importance of non-HFEmutations
  54. A Corn Oil-Based Diet Protects Against Combined Ethanol and Iron-Induced Liver Injury in a Mouse Model of Hemochromatosis
  55. Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment
  56. Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis
  57. Hepatic Iron Deposition Does Not Predict Extrahepatic Iron Loading in Mouse Models of Hereditary Hemochromatosis
  58. Iron Predicts Tolerance in Liver Transplantation
  59. A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity
  60. Non-HFE Hemochromatosis
  61. The Control of Iron Homeostasis: microRNAS Join the Party
  62. Altered lipid metabolism in Hfe-knockout mice promotes severe NAFLD and early fibrosis
  63. G80S-linked ferroportin disease: Classical ferroportin disease in an Asian family and reclassification of the mutant as iron transport defective
  64. Iron loading and oxidative stress in the Atm-/- mouse liver
  65. Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2
  66. Syntaxin 5 Is Required for Copper Homeostasis in Drosophila and Mammals
  67. Transferrin Receptor 1: A Ferritin Receptor as Well?
  68. Increased Iron Stores Correlate with Worse Disease Outcomes in a Mouse Model of Schistosomiasis Infection
  69. Centrobin regulates the assembly of functional mitotic spindles
  70. Identification of Ferritin Receptors: Their Role in Iron Homeostasis, Hepatic Injury, and Inflammation
  71. Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype
  72. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
  73. Hepcidin Regulation by HFE and TFR2: Is It Enough to Give a Hepatocyte a Complex?
  74. Co-factors in liver disease: The role of HFE-related hereditary hemochromatosis and iron
  75. Carrier-Mediated Thyroid Hormone Transport into Placenta by Placental Transthyretin
  76. Regulation of Iron Homeostasis: Is It All in the HBD?
  77. Juvenile iron overload—Advances, but no answers
  78. Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis
  79. Lymphotoxin-β receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury
  80. Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression
  81. How much iron is too much?
  82. Defective trafficking and localization of mutated transferrin receptor 2: implications for type 3 hereditary hemochromatosis
  83. A novel mutation in ferroportin implicated in iron overload
  85. Targeted Disruption of the Hepatic Transferrin Receptor 2 Gene in Mice Leads to Iron Overload
  86. The Clinical Relevance of Compound Heterozygosity for the C282Y and H63D Substitutions in Hemochromatosis
  87. Clinical expression of C282Y homozygous HFE haemochromatosis at 14 years of age
  88. Screening for Hemochromatosis in Asymptomatic Subjects With or Without a Family History
  89. Purification and partial characterisation of recombinant human hepcidin
  90. Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes
  91. Ferroportin disease due to the A77D mutation in Australia
  92. First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
  93. Identification of ferroportin disease in the Indian subcontinent
  94. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus
  95. HFE gene and hemochromatosis
  96. Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosis
  97. Inactivation of the murineTransferrin Receptor 2 gene using the Cre recombinase:LoxP system
  98. A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient
  99. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
  100. Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis
  101. Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282Y
  102. Molecular and Cellular Characterization of Transferrin Receptor 2
  103. Role of p97 and Syntaxin 5 in the Assembly of Transitional Endoplasmic Reticulum
  104. Haemochromatosis in the new millenium
  105. cDNA Characterization and Chromosomal Mapping of Human Golgi SNARE GS27 and GS28 to Chromosome 17
  106. A 29-Kilodalton Golgi SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Vti1-rp2) Implicated in Protein Trafficking in the Secretory Pathway
  107. The Mammalian Protein (rbet1) Homologous to Yeast Bet1p Is Primarily Associated with the Pre-Golgi Intermediate Compartment and Is Involved in Vesicular Transport from the Endoplasmic Reticulum to the Golgi Apparatus
  108. N-Ethylmaleimide-sensitive Factor (NSF) and  -Soluble NSF Attachment Proteins (SNAP) Mediate Dissociation of GS28-Syntaxin 5 Golgi SNAP Receptors (SNARE) Complex
  109. GS15, a 15-Kilodalton Golgi SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (SNARE) Homologous to rbet1
  110. GS28, a 28-Kilodalton Golgi SNARE That Participates in ER-Golgi Transport
  111. cDNA Cloning and Characterization of Rat Salivary Glycoproteins. Novel Members of the Proline-Rich-Protein Multigene Families
  112. cDNA Cloning and Characterization of Rat Salivary Glycoproteins. Novel Members of the Proline-Rich-Protein Multigene Families
  113. cDNA Cloning and Characterization of Rat Salivary Glycoproteins. Novel Members of the Proline-Rich-Protein Multigene Families