All Stories

  1. Microbial cell-free DNA sequencing of bronchoalveolar lavage fluid improves diagnostic yield and may add clinical utility in immunocompromised patients with severe pneumonia
  2. Umbilical Cord Blood Cell Transcriptional and Methylation Signatures at Birth Are Associated with BPD Development.
  3. Systematic data capture reduces the need for source data verification: exploratory analysis from a phase 2 multicenter randomized controlled platform trial
  4. Large language models accurately identify immunosuppression in intensive care unit patients
  5. Maintenance DNA methylation is required for induced Treg reparative function following viral pneumonia in mice
  6. Welsh, González, and Negulescu share Lasker Award recognizing transformative treatments for people with cystic fibrosis
  7. Multi-omics profiling in severe pneumonia: the importance of robust study design
  8. Developing and validating machine learning models to predict next-day extubation
  9. Multi-omic and Single-Cell Approaches for Elucidating Cell Biology and Pathobiology of Lung Disease
  10. Development of a pilot machine learning model to predict successful cure in critically ill patients with community-acquired pneumonia
  11. Understanding Diagnostic Uncertainty: Comparing Pre-Test Probability of Pneumonia to Bronchoalveolar Lavage Results in Critically Ill Patients
  12. Novel enzyme-based reduced representation method for DNA methylation profiling with low inputs
  13. Antibiotic de-escalation patterns and outcomes in critically ill patients with suspected pneumonia as informed by bronchoalveolar lavage results
  14. Regulatory T Cells Require TBET to Regulate Activated CD8+ T Cells During Recovery from Influenza
  15. AMPK is necessary for Treg functional adaptation to microenvironmental stress during malignancy and viral pneumonia
  16. Maintenance DNA methylation is required for induced regulatory T cell reparative function following viral pneumonia
  17. An observational cohort study of bronchoalveolar lavage fluid galactomannan and Aspergillus culture positivity in patients requiring mechanical ventilation
  18. Large language models outperform traditional structured data-based approaches in identifying immunosuppressed patients
  19. Distinct Control of histone H1 expression within the Histone Locus body by CRAMP1
  20. The Fifth Annual Symposium of the Midwest Aging Consortium
  21. Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia
  22. Antibiotic De-escalation Patterns and Outcomes in Critically Ill Patients with Suspected Pneumonia as Informed by Bronchoalveolar Lavage Results
  23. Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia
  24. Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
  25. Transitions in lung microbiota landscape associate with distinct patterns of pneumonia progression
  26. Developing and validating a machine learning model to predict successful next-day extubation in the ICU
  27. FOXP3+ Regulatory T Cells Require TBET to Regulate Activated CD8+ T Cells During Recovery from Influenza Infection
  28. Novel enzyme-based reduced representation method for DNA methylation profiling with low inputs
  29. Mitochondria regulate proliferation in adult cardiac myocytes
  30. Neutrophil percentages in bronchoalveolar lavage fluid: Implications for diagnosing bacterial pneumonia in patients with immunocompromise and neutropenia
  31. Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19
  32. A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer
  33. Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial
  34. Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in Ataxia Telangiectasia
  35. Culturing the Future of Medicine: The Imperative of Strengthening the ID Physician-Scientist Pipeline
  36. An observational cohort study of bronchoalveolar lavage fluid galactomannan and Aspergillus culture positivity in patients requiring mechanical ventilation
  37. Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation
  38. A distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
  39. AMP-activated protein kinase is necessary for Treg cell functional adaptation to microenvironmental stress
  40. ELOA3 : A primate-specific RNA polymerase II elongation factor encoded by a tandem repeat gene cluster
  41. Temporal correlation between postreperfusion complement deposition and severe primary graft dysfunction in lung allografts
  42. Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in ataxia telangiectasia
  43. Reply: Research Bronchoscopy Standards and the Need for Non-Invasive Sampling of the Failing Lungs
  44. Prolonged exposure to lung-derived cytokines is associated with inflammatory activation of microglia in patients with COVID-19
  45. Differential roles of regulatory T cells in acute respiratory infections
  46. An Adjudication Protocol for Severe Pneumonia
  47. Finding Facts in PASC: Clinical, Radiographic and Histopathologic Markers of Disease
  48. Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli
  49. Research Bronchoscopies in Critically Ill Research Participants: An Official American Thoracic Society Workshop Report
  50. Machine learning links unresolving secondary pneumonia to mortality in patients with severe pneumonia, including COVID-19
  51. Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection
  52. Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trial
  53. Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  54. Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  55. Supplementary Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  56. Supplementary Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  57. Supplementary Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  58. Supplementary Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  59. DNA methyltransferase inhibition induces dynamic gene expression changes in lung CD4+ T cells of neonatal mice with E. coli pneumonia
  60. Aging is associated with a systemic length-associated transcriptome imbalance
  61. Superiority of intranasal over systemic administration of bioengineered soluble ACE2 for survival and brain protection against SARS-CoV-2 infection
  62. An Adjudication Protocol for Severe Bacterial and Viral Pneumonia
  63. DNA methyltransferase inhibition induces dynamic gene expression changes in lung CD4+ T cells of neonatal mice with E. coli pneumonia
  64. A machine learning approach identifies unresolving secondary pneumonia as a contributor to mortality in patients with severe pneumonia, including COVID-19
  65. Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli
  66. Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia
  67. Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report
  68. Update in COVID-19 2021
  69. Outcomes of Percutaneous Tracheostomy for Patients With SARS-CoV-2 Respiratory Failure
  70. Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
  71. Epigenetic Control of Regulatory T Cell Stability and Function: Implications for Translation
  72. Age-related Differences in the Nasal Mucosal Immune Response to SARS-CoV-2
  73. Local and systemic responses to SARS-CoV-2 infection in children and adults
  74. Toward a Paradigm to Distinguish Distinct Functions of FOXP3+ Regulatory T Cells
  75. Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia
  76. Technology dictates algorithms: recent developments in read alignment
  77. PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  78. Distinctive features of severe SARS-CoV-2 pneumonia
  79. Bronchoscopy on Intubated Patients with COVID-19 Is Associated with Low Infectious Risk to Operators
  80. Update in COVID-19 2020
  81. Timing of Intubation in Coronavirus Disease 2019: A Study of Ventilator Mechanics, Imaging, Findings, and Outcomes
  82. Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia
  83. mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
  84. Outcomes of Percutaneous Tracheostomy for Patients with SARS-CoV-2 Respiratory Failure
  85. The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging
  86. Bacterial superinfection pneumonia in SARS-CoV-2 respiratory failure
  87. Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia
  88. Comparing Nasopharyngeal and BAL SARS-CoV-2 Assays in Respiratory Failure
  89. Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function
  90. Age-Dependent Differences in T-Cell Responses to Influenza A Virus
  91. Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells
  92. Pathogenesis of COVID-19-induced ARDS: implications for an ageing population
  93. COVID-19 and the next influenza season
  94. A Call for Rational Intensive Care in the Era of COVID-19
  95. Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia
  96. Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation
  97. DNA methylation and gene expression signatures are associated with ataxia-telangiectasia phenotype
  98. CoRESTed development of regulatory T cells
  99. Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function
  100. Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
  101. The Socrates Project for Difficult Diagnosis at Northwestern Medicine
  102. A Practical Guide to the Measurement and Analysis of DNA Methylation
  103. Headed in the Wrong Direction: Chronic and Acute Derangements in Pulmonary Blood Flow Distribution in a Patient with Severe Pulmonary Vein Stenosis
  104. Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report
  105. The Aging Microenvironment Shapes Alveolar Macrophage Identity in Aging
  106. CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism
  107. Aging is associated with a systemic length-driven transcriptome imbalance
  108. Detection of respiratory pathogens in clinical samples using metagenomic shotgun sequencing
  109. Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis
  110. Immunometabolism of pro-repair cells
  111. DNA methylation as a transcriptional regulator of the immune system
  112. Mitochondrial complex III is essential for suppressive function of regulatory T cells
  113. Inflammation and transcriptional responses of peripheral blood mononuclear cells in classic ataxia telangiectasia
  114. Invasive Mechanical Ventilation
  115. TET2 coactivates gene expression through demethylation of enhancers
  116. Extracorporeal Membrane Oxygenation Can Successfully Support Patients With Severe Acute Respiratory Distress Syndrome in Lieu of Mechanical Ventilation
  117. Multidimensional assessment of alveolar T cells in critically ill patients
  118. Systemic Lupus Erythematosus–associated Diffuse Alveolar Hemorrhage: A Case Report and Review of the Literature
  119. DNA methylation regulates the neonatal CD4+ T-cell response to pneumonia in mice
  120. Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary Fibrosis
  121. Vitamin C and Sepsis
  122. The innate immune response to lower respiratory tract E. Coli infection and the role of the CCL2-CCR2 axis in neonatal mice
  123. Opening the Regulatory T Cell Toolbox
  124. Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
  125. Molecular and physiological manifestations and measurement of aging in humans
  126. Metastatic pulmonary calcification and end-stage renal disease
  127. Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome
  128. More Than a Touch of Gray: Embracing Uncertainty in the Intensive Care Unit
  129. Transcriptomic signatures decode Th17 cell pathogenicity
  130. Flow-cytometric method for simultaneous analysis of mouse lung epithelial, endothelial, and hematopoietic lineage cells
  131. Correction: Immunological Priming Requires Regulatory T Cells and IL-10–Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation
  132. Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming
  133. Right Ventricular Angiogenesis is an Early Adaptive Response to Chronic Hypoxia-Induced Pulmonary Hypertension
  134. Histone/protein deacetylase 3 dictates critical aspects of regulatory T cell development and function
  135. Regulatory T Cell DNA Methyltransferase Inhibition Accelerates Resolution of Lung Inflammation
  136. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting
  137. Foxp3+ Regulatory T-Cell DNA Demethylation Accelerates Resolution of Acute Lung Injury
  138. Comment on Adamzik et al.: An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality
  139. Foxp3+ regulatory T cells promote lung epithelial proliferation
  140. Immunological Priming Requires Regulatory T Cells and IL-10–Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation
  141. Regulatory T cell Itch reins in Th2 inflammation
  142. Progress Toward Improving Medical School Graduates’ Skills via a “Boot Camp” Curriculum
  143. Regulatory T Cells as Immunotherapy
  144. Retention of Critical Care Skills After Simulation-Based Mastery Learning
  145. First-Year Residents Outperform Third-Year Residents After Simulation-Based Education in Critical Care Medicine
  146. Pressure Modes of Invasive Mechanical Ventilation
  147. Prompting Physicians to Address a Daily Checklist and Process of Care and Clinical Outcomes
  148. Basic Invasive Mechanical Ventilation
  149. Severe Adverse Drug Reaction to Gadobenate Dimeglumine
  150. Research note: Increasing Amb a 1 content in common ragweed (Ambrosia artemisiifolia) pollen as a function of rising atmospheric CO2 concentration
  151. Cities as harbingers of climate change: Common ragweed, urbanization, and public health