All Stories

  1. Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19

    Article • JCI Insight, March 2024, American Society for Clinical Investigation

    Benjamin Singer

  2. A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer

    Article • Nature Communications, March 2024, Springer Science + Business Media

    Benjamin Singer

  3. Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial

    Article • Critical Care, February 2024, Springer Science + Business Media

    Benjamin Singer

  4. Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in Ataxia Telangiectasia

    Article • Orphanet Journal of Rare Diseases, February 2024, Springer Science + Business Media

    Benjamin Singer

  5. Culturing the Future of Medicine: The Imperative of Strengthening the ID Physician-Scientist Pipeline

    Article • The Journal of Infectious Diseases, February 2024, Oxford University Press (OUP)

    Benjamin Singer

  6. An observational cohort study of bronchoalveolar lavage fluid galactomannan and Aspergillus culture positivity in patients requiring mechanical ventilation

    Article • February 2024, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  7. Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation

    Article • Cell Reports Medicine, February 2024, Elsevier

    Benjamin Singer

  8. A distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia

    Article • December 2023, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  9. AMP-activated protein kinase is necessary for Treg cell functional adaptation to microenvironmental stress

    Article • December 2023, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  10. ELOA3 : A primate-specific RNA polymerase II elongation factor encoded by a tandem repeat gene cluster

    Article • Science Advances, November 2023, American Association for the Advancement of Science

    Benjamin Singer

  11. Temporal correlation between postreperfusion complement deposition and severe primary graft dysfunction in lung allografts

    Article • American Journal of Transplantation, November 2023, Elsevier

    Benjamin Singer

  12. Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in ataxia telangiectasia

    Article • October 2023, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  13. Reply: Research Bronchoscopy Standards and the Need for Non-Invasive Sampling of the Failing Lungs

    Article • Annals of the American Thoracic Society, September 2023, American Thoracic Society

    Benjamin Singer

  14. Prolonged exposure to lung-derived cytokines is associated with inflammatory activation of microglia in patients with COVID-19

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  15. Differential roles of regulatory T cells in acute respiratory infections

    Article • Journal of Clinical Investigation, July 2023, American Society for Clinical Investigation

    Benjamin Singer

  16. An Adjudication Protocol for Severe Pneumonia

    Article • Open Forum Infectious Diseases, July 2023, Oxford University Press (OUP)

    Benjamin Singer

  17. Finding Facts in PASC: Clinical, Radiographic and Histopathologic Markers of Disease

    Article • American Journal of Respiratory and Critical Care Medicine, June 2023, American Thoracic Society

    Benjamin Singer

  18. Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli

    Article • eLife, June 2023, eLife

    Benjamin Singer

  19. Research Bronchoscopies in Critically Ill Research Participants: An Official American Thoracic Society Workshop Report

    Article • Annals of the American Thoracic Society, May 2023, American Thoracic Society

    Benjamin Singer

  20. Machine learning links unresolving secondary pneumonia to mortality in patients with severe pneumonia, including COVID-19

    Article • Journal of Clinical Investigation, April 2023, American Society for Clinical Investigation

    Benjamin Singer

  21. Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection

    Article • Life Science Alliance, April 2023, Life Science Alliance, LLC

    Benjamin Singer

  22. Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trial

    Article • EClinicalMedicine, April 2023, Elsevier

    Benjamin Singer

  23. Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Benjamin Singer

  24. Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Benjamin Singer

  25. Supplementary Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Benjamin Singer

  26. Supplementary Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Benjamin Singer

  27. Supplementary Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Benjamin Singer

  28. Supplementary Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Benjamin Singer

  29. DNA methyltransferase inhibition induces dynamic gene expression changes in lung CD4+ T cells of neonatal mice with E. coli pneumonia

    Article • Scientific Reports, March 2023, Springer Science + Business Media

    Benjamin Singer

  30. Aging is associated with a systemic length-associated transcriptome imbalance

    Article • Nature Aging, December 2022, Springer Science + Business Media

    Benjamin Singer

  31. Superiority of intranasal over systemic administration of bioengineered soluble ACE2 for survival and brain protection against SARS-CoV-2 infection

    Article • December 2022, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  32. An Adjudication Protocol for Severe Bacterial and Viral Pneumonia

    Article • October 2022, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  33. DNA methyltransferase inhibition induces dynamic gene expression changes in lung CD4+ T cells of neonatal mice with E. coli pneumonia

    Article • October 2022, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  34. A machine learning approach identifies unresolving secondary pneumonia as a contributor to mortality in patients with severe pneumonia, including COVID-19

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  35. Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  36. Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia

    Article • Journal of Antimicrobial Chemotherapy, July 2022, Oxford University Press (OUP)

    Benjamin Singer

  37. Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report

    Article • American Journal of Respiratory Cell and Molecular Biology, July 2022, American Thoracic Society

    Benjamin Singer

  38. Update in COVID-19 2021

    Article • American Journal of Respiratory and Critical Care Medicine, April 2022, American Thoracic Society

    Benjamin Singer

  39. Outcomes of Percutaneous Tracheostomy for Patients With SARS-CoV-2 Respiratory Failure

    Article • Journal of Bronchology & Interventional Pulmonology, April 2022, Wolters Kluwer Health

    Benjamin Singer

  40. Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice

    Article • Scientific Reports, March 2022, Springer Science + Business Media

    Benjamin Singer

  41. Epigenetic Control of Regulatory T Cell Stability and Function: Implications for Translation

    Article • Frontiers in Immunology, March 2022, Frontiers

    Benjamin Singer

  42. Age-related Differences in the Nasal Mucosal Immune Response to SARS-CoV-2

    Article • American Journal of Respiratory Cell and Molecular Biology, February 2022, American Thoracic Society

    Benjamin Singer

  43. Local and systemic responses to SARS-CoV-2 infection in children and adults

    Article • Nature, December 2021, Springer Science + Business Media

    Benjamin Singer

  44. Toward a Paradigm to Distinguish Distinct Functions of FOXP3+ Regulatory T Cells

    Article • ImmunoHorizons, December 2021, The American Association of Immunologists

    Benjamin Singer

  45. Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia

    Article • American Journal of Respiratory and Critical Care Medicine, October 2021, American Thoracic Society

    Benjamin Singer

  46. Technology dictates algorithms: recent developments in read alignment

    Article • August 2021, Springer Science + Business Media

    Benjamin Singer

  47. PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer

    Article • Cancer Research, August 2021, American Association for Cancer Research (AACR)

    Benjamin Singer

  48. Distinctive features of severe SARS-CoV-2 pneumonia

    Article • Journal of Clinical Investigation, July 2021, American Society for Clinical Investigation

    Benjamin Singer

  49. Bronchoscopy on Intubated Patients with COVID-19 Is Associated with Low Infectious Risk to Operators

    Article • Annals of the American Thoracic Society, July 2021, American Thoracic Society

    Benjamin Singer

  50. Update in COVID-19 2020

    Article • American Journal of Respiratory and Critical Care Medicine, June 2021, American Thoracic Society

    Benjamin Singer

  51. Timing of Intubation in Coronavirus Disease 2019: A Study of Ventilator Mechanics, Imaging, Findings, and Outcomes

    Article • Critical Care Explorations, May 2021, Wolters Kluwer Health

    Benjamin Singer

  52. Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia

    Article • JCI Insight, March 2021, American Society for Clinical Investigation

    Benjamin Singer

  53. mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

    Article • Molecular Cell, March 2021, Elsevier

    Eunús S. Ali, Ph.D., Benjamin Singer

  54. Outcomes of Percutaneous Tracheostomy for Patients with SARS-CoV-2 Respiratory Failure

    Article • February 2021, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  55. The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging

    Article • Journal of Clinical Investigation, February 2021, American Society for Clinical Investigation

    Benjamin Singer

  56. Bacterial superinfection pneumonia in SARS-CoV-2 respiratory failure

    Article • January 2021, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  57. Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

    Article • Nature, January 2021, Springer Science + Business Media

    Benjamin Singer

  58. Comparing Nasopharyngeal and BAL SARS-CoV-2 Assays in Respiratory Failure

    Article • American Journal of Respiratory and Critical Care Medicine, January 2021, American Thoracic Society

    Benjamin Singer

  59. Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function

    Article • Journal of Clinical Investigation, November 2020, American Society for Clinical Investigation

    Benjamin Singer

  60. Age-Dependent Differences in T-Cell Responses to Influenza A Virus

    Article • American Journal of Respiratory Cell and Molecular Biology, October 2020, American Thoracic Society

    Benjamin Singer

  61. Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

    Article • August 2020, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  62. Pathogenesis of COVID-19-induced ARDS: implications for an ageing population

    Article • European Respiratory Journal, August 2020, European Respiratory Society (ERS)

    Benjamin Singer

  63. COVID-19 and the next influenza season

    Article • Science Advances, July 2020, American Association for the Advancement of Science

    Benjamin Singer

  64. A Call for Rational Intensive Care in the Era of COVID-19

    Article • American Journal of Respiratory Cell and Molecular Biology, July 2020, American Thoracic Society

    Benjamin Singer

  65. Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  66. Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation

    Article • Nature Genetics, May 2020, Springer Science + Business Media

    Benjamin Singer

  67. DNA methylation and gene expression signatures are associated with ataxia-telangiectasia phenotype

    Article • Scientific Reports, May 2020, Springer Science + Business Media

    Benjamin Singer

  68. CoRESTed development of regulatory T cells

    Article • Journal of Clinical Investigation, March 2020, American Society for Clinical Investigation

    Benjamin Singer

  69. Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function

    Article • February 2020, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  70. Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation

    Article • January 2020, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  71. The Socrates Project for Difficult Diagnosis at Northwestern Medicine

    Article • Journal of Hospital Medicine, November 2019, Wiley

    Benjamin Singer

  72. A Practical Guide to the Measurement and Analysis of DNA Methylation

    Article • American Journal of Respiratory Cell and Molecular Biology, October 2019, American Thoracic Society

    Benjamin Singer

  73. Headed in the Wrong Direction: Chronic and Acute Derangements in Pulmonary Blood Flow Distribution in a Patient with Severe Pulmonary Vein Stenosis

    Article • Annals of the American Thoracic Society, October 2019, American Thoracic Society

    Benjamin Singer

  74. Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report

    Article • American Journal of Respiratory Cell and Molecular Biology, August 2019, American Thoracic Society

    Benjamin Singer

  75. The Aging Microenvironment Shapes Alveolar Macrophage Identity in Aging

    Article • July 2019, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  76. CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

    Article • Science Advances, July 2019, American Association for the Advancement of Science

    Benjamin Singer

  77. Aging is associated with a systemic length-driven transcriptome imbalance

    Article • July 2019, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  78. Detection of respiratory pathogens in clinical samples using metagenomic shotgun sequencing

    Article • Journal of Medical Microbiology, July 2019, Society for General Microbiology

    Benjamin Singer

  79. Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

    Article • American Journal of Respiratory and Critical Care Medicine, June 2019, American Thoracic Society

    Benjamin Singer

  80. Immunometabolism of pro-repair cells

    Article • Journal of Clinical Investigation, May 2019, American Society for Clinical Investigation

    Benjamin Singer

  81. DNA methylation as a transcriptional regulator of the immune system

    Article • Translational Research, February 2019, Elsevier

    Benjamin Singer

  82. Mitochondrial complex III is essential for suppressive function of regulatory T cells

    Article • Nature, January 2019, Springer Science + Business Media

    Samuel Edward Weinberg, Benjamin Singer

  83. Inflammation and transcriptional responses of peripheral blood mononuclear cells in classic ataxia telangiectasia

    Article • PLoS ONE, December 2018, PLOS

    Benjamin Singer

  84. Invasive Mechanical Ventilation

    Article • Southern Medical Journal, December 2018, Southern Medical Association

    Benjamin Singer

  85. TET2 coactivates gene expression through demethylation of enhancers

    Article • Science Advances, November 2018, American Association for the Advancement of Science

    Benjamin Singer

  86. Extracorporeal Membrane Oxygenation Can Successfully Support Patients With Severe Acute Respiratory Distress Syndrome in Lieu of Mechanical Ventilation

    Article • Critical Care Medicine, November 2018, Wolters Kluwer Health

    Benjamin Singer

  87. Multidimensional assessment of alveolar T cells in critically ill patients

    Article • JCI Insight, September 2018, American Society for Clinical Investigation

    Benjamin Singer

  88. Systemic Lupus Erythematosus–associated Diffuse Alveolar Hemorrhage: A Case Report and Review of the Literature

    Article • Clinical Pulmonary Medicine, September 2018, Wolters Kluwer Health

    Benjamin Singer

  89. DNA methylation regulates the neonatal CD4+ T-cell response to pneumonia in mice

    Article • Journal of Biological Chemistry, July 2018, Elsevier

    Benjamin Singer

  90. Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary Fibrosis

    Article • April 2018, Cold Spring Harbor Laboratory Press

    Benjamin Singer

  91. Vitamin C and Sepsis

    Article • CHEST Journal, October 2017, Elsevier

    Benjamin Singer

  92. The innate immune response to lower respiratory tract E. Coli infection and the role of the CCL2-CCR2 axis in neonatal mice

    Article • Cytokine, September 2017, Elsevier

    Benjamin Singer

  93. Opening the Regulatory T Cell Toolbox

    Article • American Journal of Respiratory Cell and Molecular Biology, August 2017, American Thoracic Society

    Benjamin Singer

  94. Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

    Article • The Journal of Experimental Medicine, July 2017, Rockefeller University Press

    Benjamin Singer

  95. Molecular and physiological manifestations and measurement of aging in humans

    Article • Aging Cell, May 2017, Wiley

    Benjamin Singer

  96. Metastatic pulmonary calcification and end-stage renal disease

    Article • Cleveland Clinic Journal of Medicine, January 2017, Cleveland Clinic Journal of Medicine

    Benjamin Singer

  97. Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome

    Article • Diagnostic Microbiology and Infectious Disease, November 2016, Elsevier

    Benjamin Singer

  98. More Than a Touch of Gray: Embracing Uncertainty in the Intensive Care Unit

    Article • American Review of Respiratory Disease, October 2016, American Thoracic Society

    Benjamin Singer

  99. Transcriptomic signatures decode Th17 cell pathogenicity

    Article • Cellular and Molecular Immunology, May 2016, Springer Science + Business Media

    Benjamin Singer

  100. Flow-cytometric method for simultaneous analysis of mouse lung epithelial, endothelial, and hematopoietic lineage cells

    Article • AJP Lung Cellular and Molecular Physiology, May 2016, American Physiological Society

    Benjamin Singer

  101. Correction: Immunological Priming Requires Regulatory T Cells and IL-10–Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation

    Article • The Journal of Immunology, April 2016, The American Association of Immunologists

    Benjamin Singer

  102. Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming

    Article • AJP Lung Cellular and Molecular Physiology, April 2016, American Physiological Society

    Benjamin Singer

  103. Right Ventricular Angiogenesis is an Early Adaptive Response to Chronic Hypoxia-Induced Pulmonary Hypertension

    Article • Microcirculation, November 2015, Wiley

    Benjamin Singer

  104. Histone/protein deacetylase 3 dictates critical aspects of regulatory T cell development and function

    Article • Cellular and Molecular Immunology, June 2015, Springer Science + Business Media

    Benjamin Singer

  105. Regulatory T Cell DNA Methyltransferase Inhibition Accelerates Resolution of Lung Inflammation

    Article • American Journal of Respiratory Cell and Molecular Biology, May 2015, American Thoracic Society

    Benjamin Singer

  106. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting

    Article • Science Translational Medicine, March 2015, American Association for the Advancement of Science

    Benjamin Singer

  107. Foxp3+ Regulatory T-Cell DNA Demethylation Accelerates Resolution of Acute Lung Injury

    Article • Annals of the American Thoracic Society, March 2015, American Thoracic Society

    Benjamin Singer

  108. Comment on Adamzik et al.: An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality

    Article • Intensive Care Medicine, July 2014, Springer Science + Business Media

    Benjamin Singer

  109. Foxp3+ regulatory T cells promote lung epithelial proliferation

    Article • Mucosal Immunology, May 2014, Springer Science + Business Media

    Benjamin Singer

  110. Immunological Priming Requires Regulatory T Cells and IL-10–Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation

    Article • The Journal of Immunology, March 2014, The American Association of Immunologists

    Benjamin Singer

  111. Regulatory T cell Itch reins in Th2 inflammation

    Article • Cellular and Molecular Immunology, February 2014, Springer Science + Business Media

    Benjamin Singer

  112. Progress Toward Improving Medical School Graduates’ Skills via a “Boot Camp” Curriculum

    Article • Simulation in Healthcare The Journal of the Society for Simulation in Healthcare, February 2014, Wolters Kluwer Health

    Benjamin Singer

  113. Regulatory T Cells as Immunotherapy

    Article • Frontiers in Immunology, January 2014, Frontiers

    Benjamin Singer

  114. Retention of Critical Care Skills After Simulation-Based Mastery Learning

    Article • Journal of Graduate Medical Education, September 2013, Journal of Graduate Medical Education

    Benjamin Singer

  115. First-Year Residents Outperform Third-Year Residents After Simulation-Based Education in Critical Care Medicine

    Article • Simulation in Healthcare The Journal of the Society for Simulation in Healthcare, April 2013, Wolters Kluwer Health

    Benjamin Singer

  116. Pressure Modes of Invasive Mechanical Ventilation

    Article • Southern Medical Journal, October 2011, Southern Medical Association

    Benjamin Singer

  117. Prompting Physicians to Address a Daily Checklist and Process of Care and Clinical Outcomes

    Article • American Journal of Respiratory and Critical Care Medicine, September 2011, American Thoracic Society

    Benjamin Singer

  118. Basic Invasive Mechanical Ventilation

    Article • Southern Medical Journal, December 2009, Southern Medical Association

    Benjamin Singer

  119. Severe Adverse Drug Reaction to Gadobenate Dimeglumine

    Article • The Scientific World JOURNAL, January 2009, Hindawi Publishing Corporation

    Benjamin Singer

  120. Research note: Increasing Amb a 1 content in common ragweed (Ambrosia artemisiifolia) pollen as a function of rising atmospheric CO2 concentration

    Article • Functional Plant Biology, January 2005, CSIRO Publishing

    Benjamin Singer

  121. Cities as harbingers of climate change: Common ragweed, urbanization, and public health

    Article • Journal of Allergy and Clinical Immunology, February 2003, Elsevier

    Benjamin Singer