All Stories

  1. Human CRAMP1 specifically promotes the expression of histone H1 genes
  2. Developing and externally validating machine learning models to forecast short-term risk of ventilator-associated pneumonia
  3. Integration of bulk RNA-seq pipeline metrics for assessing low-quality samples
  4. Longitudinal clinical proteomics reveals pneumonia type-specific protein biomarkers and autoantibodies
  5. Age-dependent immune responses and resident cell dynamics in young mice following pneumonia
  6. Transitions in lung microbiota landscape associate with distinct patterns of pneumonia progression
  7. Microbial cell-free DNA sequencing of bronchoalveolar lavage fluid improves diagnostic yield and may add clinical utility in immunocompromised patients with severe pneumonia
  8. Umbilical Cord Blood Cell Transcriptional and Methylation Signatures at Birth Are Associated with BPD Development.
  9. Development of a Pilot Machine Learning Model to Predict Successful Short-term Treatment Success in Critically Ill Patients With Community-Acquired Pneumonia
  10. Systematic data capture reduces the need for source data verification: exploratory analysis from a phase 2 multicenter randomized controlled platform trial
  11. Large language models accurately identify immunosuppression in intensive care unit patients
  12. Maintenance DNA methylation is required for induced Treg reparative function following viral pneumonia in mice
  13. Welsh, González, and Negulescu share Lasker Award recognizing transformative treatments for people with cystic fibrosis
  14. Multi-omics profiling in severe pneumonia: the importance of robust study design
  15. Developing and validating machine learning models to predict next-day extubation
  16. Multi-omic and Single-Cell Approaches for Elucidating Cell Biology and Pathobiology of Lung Disease
  17. Development of a pilot machine learning model to predict successful cure in critically ill patients with community-acquired pneumonia
  18. Understanding Diagnostic Uncertainty: Comparing Pre-Test Probability of Pneumonia to Bronchoalveolar Lavage Results in Critically Ill Patients
  19. Novel enzyme-based reduced representation method for DNA methylation profiling with low inputs
  20. Antibiotic de-escalation patterns and outcomes in critically ill patients with suspected pneumonia as informed by bronchoalveolar lavage results
  21. Regulatory T Cells Require TBET to Regulate Activated CD8+ T Cells During Recovery from Influenza
  22. AMPK is necessary for Treg functional adaptation to microenvironmental stress during malignancy and viral pneumonia
  23. Maintenance DNA methylation is required for induced regulatory T cell reparative function following viral pneumonia
  24. An observational cohort study of bronchoalveolar lavage fluid galactomannan and Aspergillus culture positivity in patients requiring mechanical ventilation
  25. Large language models outperform traditional structured data-based approaches in identifying immunosuppressed patients
  26. Distinct Control of histone H1 expression within the Histone Locus body by CRAMP1
  27. The Fifth Annual Symposium of the Midwest Aging Consortium
  28. Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia
  29. Antibiotic De-escalation Patterns and Outcomes in Critically Ill Patients with Suspected Pneumonia as Informed by Bronchoalveolar Lavage Results
  30. Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia
  31. Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
  32. Transitions in lung microbiota landscape associate with distinct patterns of pneumonia progression
  33. Developing and validating a machine learning model to predict successful next-day extubation in the ICU
  34. FOXP3+ Regulatory T Cells Require TBET to Regulate Activated CD8+ T Cells During Recovery from Influenza Infection
  35. Novel enzyme-based reduced representation method for DNA methylation profiling with low inputs
  36. Mitochondria regulate proliferation in adult cardiac myocytes
  37. Neutrophil percentages in bronchoalveolar lavage fluid: Implications for diagnosing bacterial pneumonia in patients with immunocompromise and neutropenia
  38. Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19
  39. A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer
  40. Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial
  41. Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in Ataxia Telangiectasia
  42. Culturing the Future of Medicine: The Imperative of Strengthening the ID Physician-Scientist Pipeline
  43. An observational cohort study of bronchoalveolar lavage fluid galactomannan and Aspergillus culture positivity in patients requiring mechanical ventilation
  44. Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation
  45. A distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
  46. AMP-activated protein kinase is necessary for Treg cell functional adaptation to microenvironmental stress
  47. ELOA3 : A primate-specific RNA polymerase II elongation factor encoded by a tandem repeat gene cluster
  48. Temporal correlation between postreperfusion complement deposition and severe primary graft dysfunction in lung allografts
  49. Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in ataxia telangiectasia
  50. Reply: Research Bronchoscopy Standards and the Need for Non-Invasive Sampling of the Failing Lungs
  51. Prolonged exposure to lung-derived cytokines is associated with inflammatory activation of microglia in patients with COVID-19
  52. Differential roles of regulatory T cells in acute respiratory infections
  53. An Adjudication Protocol for Severe Pneumonia
  54. Finding Facts in PASC: Clinical, Radiographic and Histopathologic Markers of Disease
  55. Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli
  56. Research Bronchoscopies in Critically Ill Research Participants: An Official American Thoracic Society Workshop Report
  57. Machine learning links unresolving secondary pneumonia to mortality in patients with severe pneumonia, including COVID-19
  58. Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection
  59. Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trial
  60. Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  61. Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  62. Supplementary Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  63. Supplementary Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  64. Supplementary Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  65. Supplementary Data from PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  66. DNA methyltransferase inhibition induces dynamic gene expression changes in lung CD4+ T cells of neonatal mice with E. coli pneumonia
  67. Aging is associated with a systemic length-associated transcriptome imbalance
  68. Superiority of intranasal over systemic administration of bioengineered soluble ACE2 for survival and brain protection against SARS-CoV-2 infection
  69. An Adjudication Protocol for Severe Bacterial and Viral Pneumonia
  70. DNA methyltransferase inhibition induces dynamic gene expression changes in lung CD4+ T cells of neonatal mice with E. coli pneumonia
  71. A machine learning approach identifies unresolving secondary pneumonia as a contributor to mortality in patients with severe pneumonia, including COVID-19
  72. Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli
  73. Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia
  74. Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report
  75. Update in COVID-19 2021
  76. Outcomes of Percutaneous Tracheostomy for Patients With SARS-CoV-2 Respiratory Failure
  77. Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
  78. Epigenetic Control of Regulatory T Cell Stability and Function: Implications for Translation
  79. Age-related Differences in the Nasal Mucosal Immune Response to SARS-CoV-2
  80. Local and systemic responses to SARS-CoV-2 infection in children and adults
  81. Toward a Paradigm to Distinguish Distinct Functions of FOXP3+ Regulatory T Cells
  82. Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia
  83. Technology dictates algorithms: recent developments in read alignment
  84. PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
  85. Distinctive features of severe SARS-CoV-2 pneumonia
  86. Bronchoscopy on Intubated Patients with COVID-19 Is Associated with Low Infectious Risk to Operators
  87. Update in COVID-19 2020
  88. Timing of Intubation in Coronavirus Disease 2019: A Study of Ventilator Mechanics, Imaging, Findings, and Outcomes
  89. Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia
  90. mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
  91. Outcomes of Percutaneous Tracheostomy for Patients with SARS-CoV-2 Respiratory Failure
  92. The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging
  93. Bacterial superinfection pneumonia in SARS-CoV-2 respiratory failure
  94. Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia
  95. Comparing Nasopharyngeal and BAL SARS-CoV-2 Assays in Respiratory Failure
  96. Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function
  97. Age-Dependent Differences in T-Cell Responses to Influenza A Virus
  98. Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells
  99. Pathogenesis of COVID-19-induced ARDS: implications for an ageing population
  100. COVID-19 and the next influenza season
  101. A Call for Rational Intensive Care in the Era of COVID-19
  102. Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia
  103. Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation
  104. DNA methylation and gene expression signatures are associated with ataxia-telangiectasia phenotype
  105. CoRESTed development of regulatory T cells
  106. Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function
  107. Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
  108. The Socrates Project for Difficult Diagnosis at Northwestern Medicine
  109. A Practical Guide to the Measurement and Analysis of DNA Methylation
  110. Headed in the Wrong Direction: Chronic and Acute Derangements in Pulmonary Blood Flow Distribution in a Patient with Severe Pulmonary Vein Stenosis
  111. Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report
  112. The Aging Microenvironment Shapes Alveolar Macrophage Identity in Aging
  113. CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism
  114. Aging is associated with a systemic length-driven transcriptome imbalance
  115. Detection of respiratory pathogens in clinical samples using metagenomic shotgun sequencing
  116. Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis
  117. Immunometabolism of pro-repair cells
  118. DNA methylation as a transcriptional regulator of the immune system
  119. Mitochondrial complex III is essential for suppressive function of regulatory T cells
  120. Inflammation and transcriptional responses of peripheral blood mononuclear cells in classic ataxia telangiectasia
  121. Invasive Mechanical Ventilation
  122. TET2 coactivates gene expression through demethylation of enhancers
  123. Extracorporeal Membrane Oxygenation Can Successfully Support Patients With Severe Acute Respiratory Distress Syndrome in Lieu of Mechanical Ventilation
  124. Multidimensional assessment of alveolar T cells in critically ill patients
  125. Systemic Lupus Erythematosus–associated Diffuse Alveolar Hemorrhage: A Case Report and Review of the Literature
  126. DNA methylation regulates the neonatal CD4+ T-cell response to pneumonia in mice
  127. Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary Fibrosis
  128. Vitamin C and Sepsis
  129. The innate immune response to lower respiratory tract E. Coli infection and the role of the CCL2-CCR2 axis in neonatal mice
  130. Opening the Regulatory T Cell Toolbox
  131. Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
  132. Molecular and physiological manifestations and measurement of aging in humans
  133. Metastatic pulmonary calcification and end-stage renal disease
  134. Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome
  135. More Than a Touch of Gray: Embracing Uncertainty in the Intensive Care Unit
  136. Transcriptomic signatures decode Th17 cell pathogenicity
  137. Flow-cytometric method for simultaneous analysis of mouse lung epithelial, endothelial, and hematopoietic lineage cells
  138. Correction: Immunological Priming Requires Regulatory T Cells and IL-10–Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation
  139. Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming
  140. Right Ventricular Angiogenesis is an Early Adaptive Response to Chronic Hypoxia-Induced Pulmonary Hypertension
  141. Histone/protein deacetylase 3 dictates critical aspects of regulatory T cell development and function
  142. Regulatory T Cell DNA Methyltransferase Inhibition Accelerates Resolution of Lung Inflammation
  143. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting
  144. Foxp3+ Regulatory T-Cell DNA Demethylation Accelerates Resolution of Acute Lung Injury
  145. Comment on Adamzik et al.: An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality
  146. Foxp3+ regulatory T cells promote lung epithelial proliferation
  147. Immunological Priming Requires Regulatory T Cells and IL-10–Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation
  148. Regulatory T cell Itch reins in Th2 inflammation
  149. Progress Toward Improving Medical School Graduates’ Skills via a “Boot Camp” Curriculum
  150. Regulatory T Cells as Immunotherapy
  151. Retention of Critical Care Skills After Simulation-Based Mastery Learning
  152. First-Year Residents Outperform Third-Year Residents After Simulation-Based Education in Critical Care Medicine
  153. Pressure Modes of Invasive Mechanical Ventilation
  154. Prompting Physicians to Address a Daily Checklist and Process of Care and Clinical Outcomes
  155. Basic Invasive Mechanical Ventilation
  156. Severe Adverse Drug Reaction to Gadobenate Dimeglumine
  157. Research note: Increasing Amb a 1 content in common ragweed (Ambrosia artemisiifolia) pollen as a function of rising atmospheric CO2 concentration
  158. Cities as harbingers of climate change: Common ragweed, urbanization, and public health