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  1. Sensing molecular carbon dioxide: a translational focus for respiratory disease

    Article • Physiological Reviews, October 2025, American Physiological Society

    Dr. Peter H. Sporn

  2. Clinical Cases in the Diagnosis of Cardiac Sarcoidosis

    Article • JACC Case Reports, July 2025, Elsevier

    Dr. Peter H. Sporn

  3. Hypercapnia Increases Influenza A Virus Infection of Bronchial Epithelial Cells by Augmenting Cellular Cholesterol via mTOR and Akt

    Article • International Journal of Molecular Sciences, April 2025, MDPI AG

    Dr. Peter H. Sporn

  4. Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia

    Article • Nature Immunology, August 2024, Springer Science + Business Media

    Benjamin Singer, Manoj kandpal, Dr. Peter H. Sporn

  5. Therapeutic doses of efzofitimod demonstrate efficacy in pulmonary sarcoidosis

    Article • ERJ Open Research, August 2024, European Respiratory Society (ERS)

    Dr. Peter H. Sporn

  6. The Time for Race-Neutral Pulmonary Function Norms is Now

    Article • Health Equity, May 2024, Mary Ann Liebert Inc

    Dr. Peter H. Sporn

  7. Hypercapnia increases ACE2 expression and pseudo-SARS-CoV-2 entry in bronchial epithelial cells by augmenting cellular cholesterol

    Article • Frontiers in Immunology, October 2023, Frontiers

    Dr. Peter H. Sporn

  8. Efzofitimod for the Treatment of Pulmonary Sarcoidosis

    Article • CHEST Journal, April 2023, Elsevier

    Dr. Peter H. Sporn

  9. MyeloidZfhx3Deficiency Protects Against Hypercapnia-induced Suppression of Host Defense Against Influenza A Virus

    Article • March 2023, Cold Spring Harbor Laboratory Press

    Dr. Peter H. Sporn

  10. A Novel MIP-1–Expressing Macrophage Subtype in BAL Fluid from Healthy Volunteers

    Article • American Journal of Respiratory Cell and Molecular Biology, February 2023, American Thoracic Society

    Dr. Peter H. Sporn

  11. Comparing Racial Differences in Emphysema Prevalence Among Adults With Normal Spirometry: A Secondary Data Analysis of the CARDIA Lung Study

    Article • Annals of Internal Medicine, August 2022, American College of Physicians

    Dr. Peter H. Sporn

  12. Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia

    Article • Journal of Antimicrobial Chemotherapy, July 2022, Oxford University Press (OUP)

    Benjamin Singer, Dr. Peter H. Sporn

  13. Heart transplantation outcomes in cardiac sarcoidosis

    Article • The Journal of Heart and Lung Transplantation, January 2022, Elsevier

    Dr. Peter H. Sporn

  14. ACE high: when it's not a winner for diagnosis of sarcoidosis

    Article • Translational Research, April 2021, Elsevier

    Dr. Peter H. Sporn

  15. Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage

    Article • Interface Focus, February 2021, Royal Society Publishing

    Dr. Peter H. Sporn

  16. Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

    Article • Nature, January 2021, Springer Science + Business Media

    Benjamin Singer, Manoj kandpal, Dr. Peter H. Sporn

  17. Chlorine Gas, Airway Inflammation, and Cysteinyl Leukotrienes: The Neutrophil Does Not Work Alone

    Article • American Journal of Respiratory Cell and Molecular Biology, November 2020, American Thoracic Society

    Dr. Peter H. Sporn

  18. Epithelial cell–specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice

    Article • Science Advances, August 2020, American Association for the Advancement of Science

    Dr. Peter H. Sporn

  19. Hypercapnia Suppresses Macrophage Antiviral Activity and Increases Mortality of Influenza A Infection via Akt1

    Article • The Journal of Immunology, July 2020, The American Association of Immunologists

    Dr. Peter H. Sporn

  20. Hypercapnia Suppresses Macrophage Antiviral Activity and Increases Mortality of Influenza A Infection via Akt1

    Article • February 2020, Cold Spring Harbor Laboratory Press

    Dr. Peter H. Sporn

  21. Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

    Article • Scientific Reports, December 2019, Springer Science + Business Media

    Dr. Peter H. Sporn

  22. Mechanism of benefit of non‐invasive ventilation in COPD with hypercapnic respiratory failure

    Article • Respirology, March 2019, Wiley

    Dr. Peter H. Sporn

  23. Hypercapnia Alters Expression of Immune Response, Nucleosome Assembly and Lipid Metabolism Genes in Differentiated Human Bronchial Epithelial Cells

    Article • Scientific Reports, September 2018, Springer Science + Business Media

    Dr. Peter H. Sporn

  24. Dynamics of Influenza-induced Lung-Resident Memory T Cells, Anatomically and Functionally Distinct Lung Mesenchymal Populations, and Dampening of Acute Lung Injury by Neutrophil Transfer of Micro-RNA-223 to Lung Epithelial Cells

    Article • American Journal of Respiratory Cell and Molecular Biology, September 2018, American Thoracic Society

    Dr. Peter H. Sporn

  25. A role for heat shock factor 1 in hypercapnia-induced inhibition of inflammatory cytokine expression

    Article • The FASEB Journal, July 2018, Federation of American Societies For Experimental Biology (FASEB)

    Dr. Peter H. Sporn

  26. Health equity in Israel

    Article • The Lancet, February 2018, Elsevier

    Dr. Peter H. Sporn

  27. Postextubation High-Flow Nasal Cannula Oxygen, Randomized Trial of an ICU Quality Improvement Intervention, and Midodrine during Recovery from Septic Shock

    Article • American Review of Respiratory Disease, March 2017, American Thoracic Society

    Dr. Peter H. Sporn

  28. Dimensions and Role-Specific Mediators of Surrogate Trust in the ICU

    Article • Critical Care Medicine, December 2016, Wolters Kluwer Health

    Dr. Peter H. Sporn

  29. Wandering Pleural Mesothelial Fatty Cyst

    Article • American Review of Respiratory Disease, November 2016, American Thoracic Society

    Dr. Peter H. Sporn

  30. Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia

    Article • Journal of Biological Chemistry, April 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Peter H. Sporn

  31. Focused Screening Identifies Evoxine as a Small Molecule That Counteracts CO2-Induced Immune Suppression

    Article • SLAS DISCOVERY, April 2016, SAGE Publications

    Dr. Peter H. Sporn

  32. Pleural Hypercarbia After Lung Surgery Is Associated With Persistent Alveolopleural Fistulae

    Article • CHEST Journal, January 2016, Elsevier

    Dr. Peter H. Sporn

  33. Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen

    Article • The Journal of Immunology, December 2015, The American Association of Immunologists

    Dr. Peter H. Sporn

  34. Decreased CXCL12 is associated with impaired alveolar epithelial cell migration and poor lung healing after lung resection

    Article • Surgery, October 2015, Elsevier

    Dr. Peter H. Sporn

  35. Pleural Gas Analysis for Detection of Alveolopleural Fistulae

    Article • The Annals of Thoracic Surgery, June 2015, Elsevier

    Dr. Peter H. Sporn

  36. Hypercapnia Inhibits Autophagy and Bacterial Killing in Human Macrophages by Increasing Expression of Bcl-2 and Bcl-xL

    Article • The Journal of Immunology, April 2015, The American Association of Immunologists

    Dr. Peter H. Sporn

  37. Effects of Hypercapnia in Lung Tissue Repair and Transplant

    Article • Current Transplantation Reports, January 2015, Springer Science + Business Media

    Dr. Peter H. Sporn

  38. Bilateral Diaphragm Weakness after Chemotherapy for Lymphoma

    Article • American Review of Respiratory Disease, April 2014, American Thoracic Society

    Dr. Peter H. Sporn

  39. Chronic Obstructive Pulmonary Disease Fact Sheets from the Centers for Disease Control and Prevention

    Article • Annals of the American Thoracic Society, February 2014, American Thoracic Society

    Dr. Peter H. Sporn

  40. Hypercapnia Impairs Lung Neutrophil Function and Increases Mortality in MurinePseudomonasPneumonia

    Article • American Journal of Respiratory Cell and Molecular Biology, November 2013, American Thoracic Society

    Dr Alan R Hauser, Dr. Peter H. Sporn

  41. Dimensions and Mediators of Surrogate Trust in the Intensive Care Unit

    Article • CHEST Journal, October 2013, Elsevier

    Dr. Peter H. Sporn

  42. Carbon dioxide-sensing in organisms and its implications for human disease

    Article • Cellular and Molecular Life Sciences, September 2013, Springer Science + Business Media

    Dr. Peter H. Sporn

  43. Fever Control Using External Cooling in Septic Shock

    Article • American Review of Respiratory Disease, June 2013, American Thoracic Society

    Dr. Peter H. Sporn

  44. Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ

    Article • Nature Immunology, March 2013, Nature

    Dr. Peter H. Sporn

  45. Reversibility Of Hypercapnia-Induced Mortality And Reduction Of Neutrophil H2O2 Generation In Murine Pseudomonas Pneumonia

    Article • May 2012, American Thoracic Society

    Dr. Peter H. Sporn

  46. Hypercapnia: A Nonpermissive Environment for the Lung

    Article • American Journal of Respiratory Cell and Molecular Biology, April 2012, American Thoracic Society

    Dr. Peter H. Sporn, Istvan Vadasz

  47. Recommended Reading from Northwestern University Fellows

    Article • American Review of Respiratory Disease, October 2011, American Thoracic Society

    Dr. Peter H. Sporn

  48. Hypercapnia Selectively Modulates Gene Expression In Lipopolysaccharide-Stimulated Macrophages

    Article • May 2011, American Thoracic Society

    Dr. Peter H. Sporn

  49. Hypercapnia Inhibits Bacterial Phagocytosis And Reactive Oxygen Species Generation In Neutrophils

    Article • May 2011, American Thoracic Society

    Dr. Peter H. Sporn

  50. Hypercapnia Impairs Lung Bacterial Clearance And Increases Mortality In Murine Pseudomonas Pneumonia

    Article • May 2010, American Thoracic Society

    Dr Alan R Hauser, Dr. Peter H. Sporn

  51. MicroRNA Profile Of Epithelial-Mesenchymal Transition In Normal Human Bronchial Epithelial Cells

    Article • May 2010, American Thoracic Society

    Dr. Peter H. Sporn

  52. Hypercapnia Inhibits Lipopolysaccharide-induced Interleukin-6 Gene Transcription In The Macrophage

    Article • May 2010, American Thoracic Society

    Dr. Peter H. Sporn

  53. Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage

    Article • The FASEB Journal, February 2010, Federation of American Societies For Experimental Biology (FASEB)

    Dr. Peter H. Sporn

  54. Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: a three-dimensional FRET study

    Article • Journal of Cell Science, January 2010, The Company of Biologists

    Dr. Peter H. Sporn

  55. Elevated CO2suppresses specific Drosophila innate immune responses and resistance to bacterial infection

    Article • Proceedings of the National Academy of Sciences, November 2009, Proceedings of the National Academy of Sciences

    Dr. Peter H. Sporn

  56. Essential Roles for Early Growth Response Transcription Factor Egr-1 in Tissue Fibrosis and Wound Healing

    Article • American Journal Of Pathology, September 2009, Elsevier

    Dr. Peter H. Sporn

  57. TGF-β-Dependent Epithelial-Mesenchymal Transition in Normal Human Bronchial Epithelial Cells Triggered by Eosinophils and Cyclic Mechanical Strain.

    Article • April 2009, American Thoracic Society

    Dr. Peter H. Sporn

  58. A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis

    Article • Clinical & Experimental Allergy, November 2007, Wiley

    Dr. Peter H. Sporn

  59. Extracellular Matrix Remodeling by Dynamic Strain in a Three-Dimensional Tissue-Engineered Human Airway Wall Model

    Article • American Journal of Respiratory Cell and Molecular Biology, September 2006, American Thoracic Society

    Dr. Peter H. Sporn

  60. 46 HYPERCAPNIA INDUCES MUCIN GENE EXPRESSION IN HUMAN AIRWAY EPITHELIAL CELLS.

    Article • Journal of Investigative Medicine, March 2006, BMJ

    Dr. Peter H. Sporn

  61. Leukotriene D 4 Activates Alveolar Epithelial Na,K-ATPase and Increases Alveolar Fluid Clearance

    Article • American Review of Respiratory Disease, February 2004, American Thoracic Society

    Dr. Peter H. Sporn

  62. An in vitro airway wall model of remodeling

    Article • AJP Lung Cellular and Molecular Physiology, August 2003, American Physiological Society

    Dr. Peter H. Sporn

  63. Regulation of 5-lipoxygenase activity in mononuclear phagocytes: characterization of an endogenous cytosolic inhibitor

    Article • Prostaglandins & Other Lipid Mediators, June 1998, Elsevier

    Dr. Peter H. Sporn

  64. Keratinocyte Growth Factor Increases LTC4 Synthesis and Expression of Flap in Cultured Rat Alveolar Type II Cells

    Article • January 1997, Springer Science + Business Media

    Dr. Peter H. Sporn

  65. Reduced Superoxide Dismutase in Lung Cells of Patients with Asthma

    Article • Free Radical Biology and Medicine, January 1997, Elsevier

    Dr. Peter H. Sporn

  66. Increased 5-lipoxygenase metabolism in the lungs of human subjects exposed to ozone

    Article • Toxicology, December 1996, Elsevier

    Dr. Peter H. Sporn

  67. Hydrogen Peroxide Increases the Availability of Arachidonic Acid for Oxidative Metabolism by Inhibiting Acylation into Phospholipids in the Alveolar Macrophage

    Article • American Journal of Respiratory Cell and Molecular Biology, September 1992, American Thoracic Society

    Dr. Peter H. Sporn

  68. Differential dependence on protein kinase C of arachidonic acid metabolism stimulated by hydrogen peroxide and by zymosan in the alveolar macrophage

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, November 1990, Elsevier

    Dr. Peter H. Sporn

  69. Glucocorticoids Fail to Inhibit Arachidonic Acid Metabolism Stimulated by Hydrogen Peroxide in the Alveolar Macrophage

    Article • Journal of Leukocyte Biology, July 1990, Wiley

    Dr. Peter H. Sporn

  70. Complex Effects of In Vitro Hyperoxia on Alveolar Macrophage Arachidonic Acid Metabolism

    Article • American Journal of Respiratory Cell and Molecular Biology, January 1990, American Thoracic Society

    Dr. Peter H. Sporn

  71. Hydrogen-Peroxide-induced Arachidonic Acid Metabolism in the Rat Alveolar Macrophage

    Article • American Review of Respiratory Disease, January 1988, American Thoracic Society

    Dr. Peter H. Sporn

  72. Fever and Pneumopericardium in a Patient with Systemic Sclerosis

    Article • CHEST Journal, July 1986, Elsevier

    Dr. Peter H. Sporn

  73. Nonoliguric acute renal failure after captopril therapy

    Article • Archives of Internal Medicine, June 1983, American Medical Association (AMA)

    Dr. Peter H. Sporn

  74. Nonoliguric Acute Renal Failure After Captopril Therapy

    Article • Archives of Internal Medicine, June 1983, American Medical Association (AMA)

    Dr. Peter H. Sporn