All Stories

  1. 1H, 13C, and 15N resonance assignments and solution structure of the N-terminal divergent calponin homology (NN-CH) domain of human intraflagellar transport protein 54
  2. Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2
  3. Through Diffusion Measurements of Molecules to a Numerical Model for Protein Crystallization in Viscous Polyethylene Glycol Solution
  4. 1H, 13C, and 15N resonance assignments and solution structures of the KH domain of human ribosome binding factor A, mtRbfA, involved in mitochondrial ribosome biogenesis
  5. Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles
  6. 1H, 13C and 15N resonance assignments and solution structures of the two RRM domains of Matrin-3
  7. Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva
  8. The ubiquinone synthesis pathway is a promising drug target for Chagas disease
  9. 1H, 13C and 15N resonance assignment of the YTH domain of YTHDC2
  10. Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method
  11. Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design A...
  12. Design, Synthesis and Structure-Activity Relationship Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors
  13. Identification of small molecule inhibitors of human COQ7
  14. Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei
  15. Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase
  16. Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H)
  17. Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies
  18. Identification of pyrrolo[2,3- d ]pyrimidines as potent HCK and FLT3-ITD dual inhibitors
  19. Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen
  20. Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase
  21. The Open Form Inducer Approach for Structure-Based Drug Design
  22. Molecular basis for the reverse reaction ofAfrican human trypanosomes glycerol kinase
  23. RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing
  24. Crystal structures of the S6K1 kinase domain in complexes with inhibitors
  25. Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002
  26. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
  27. Two-Colored Fluorescence Correlation Spectroscopy Screening for LC3-P62 Interaction Inhibitors
  28. Biochemical characterization of highly active Trypanosoma brucei gambiense glycerol kinase, a promising drug target
  29. A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo
  30. Structure of the trypanosome cyanide-insensitive alternative oxidase
  31. Prediction of Ligand-Induced Structural Polymorphism of Receptor Interaction Sites Using Machine Learning
  32. A Fluorescent-Based High-Throughput Screening Assay for Small Molecules That Inhibit the Interaction of MdmX with p53
  33. Insights from Pim1 structure for anti-cancer drug design
  34. Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor
  35. Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures
  36. Rational Evolution of a Novel Type of Potent and Selective Proviral Integration Site in Moloney Murine Leukemia Virus Kinase 1 (PIM1) Inhibitor from a Screening-Hit Compound
  37. Application of Support Vector Machine to Three-Dimensional Shape-Based Virtual Screening Using Comprehensive Three-Dimensional Molecular Shape Overlay with Known Inhibitors
  38. A Novel Pim-1 Kinase Inhibitor Targeting Residues That Bind the Substrate Peptide
  39. Molecular interaction of the first 3 enzymes of the de novo pyrimidine biosynthetic pathway of Trypanosoma cruzi
  40. Critical importance of the de novo pyrimidine biosynthesis pathway for Trypanosoma cruzi growth in the mammalian host cell cytoplasm
  41. Structural basis for the dual RNA-recognition modes of human Tra2-β RRM
  42. A fluorescence correlation spectroscopy-based assay for fragment screening of slowly inhibiting protein–peptide interaction inhibitors
  43. Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2
  44. Erratum to: The NMR solution structures of the five constituent cold-shock domains (CSD) of the human UNR (upstream of N-ras) protein
  45. The NMR solution structures of the five constituent cold-shock domains (CSD) of the human UNR (upstream of N-ras) protein
  46. Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain
  47. Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidase fromTrypanosoma brucei brucei
  48. Overproduction, purification, crystallization and preliminary X-ray diffraction analysis ofTrypanosoma brucei gambienseglycerol kinase
  49. Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state
  50. Solution structure of the C-terminal DUF1000 domain of the human thioredoxin-like 1 protein
  51. NMR solution structures of actin depolymerizing factor homology domains
  52. Structural and Functional Characterization of the NHR1 Domain of the Drosophila Neuralized E3 Ligase in the Notch Signaling Pathway
  53. Crystallization and preliminary X-ray analysis of aspartate transcarbamoylase from the parasitic protistTrypanosoma cruzi
  54. Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3
  55. Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator
  56. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily
  57. Solution structure of the GUCT domain from human RNA helicase II/Guβ reveals the RRM fold, but implausible RNA interactions
  58. Structure of the C-terminal Phosphotyrosine Interaction Domain of Fe65L1 Complexed with the Cytoplasmic Tail of Amyloid Precursor Protein Reveals a Novel Peptide Binding Mode
  59. Structural basis for controlling the dimerization and stability of the WW domains of an atypical subfamily
  60. The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition
  61. Development of a novel fluorescent probe for fluorescence correlation spectroscopic detection of kinase inhibitors
  62. Contribution of structural biology to clinically validated target proteins
  63. Solution Structure of the Second RNA Recognition Motif (RRM) Domain of Murine T Cell Intracellular Antigen-1 (TIA-1) and Its RNA Recognition Mode
  64. Crystal Structure of Human Ribosomal Protein L10 Core Domain Reveals Eukaryote-Specific Motifs in Addition to the Conserved Fold
  65. Solution structure of the RNA binding domain in the human muscleblind-like protein 2
  66. Structure of the human Tim44 C-terminal domain in complex with pentaethylene glycol: ligand-bound form
  67. Purification, crystallization and preliminary X-ray diffraction study of human ribosomal protein L10 core domain
  68. Solution structure of the zinc finger HIT domain in protein FON
  69. Structural basis for the recognition between the regulatory particles Nas6 and Rpt3 of the yeast 26S proteasome
  70. Purification, crystallization and preliminary X-ray diffraction of the C-terminal bromodomain from human BRD2
  71. Crystal Structure Analysis of the PHD Domain of the Transcription Co-activator Pygopus
  72. AfsR Recruits RNA Polymerase to the afsS Promoter: A Model for Transcriptional Activation by SARPs
  73. Structural and Functional Differences of SWIRM Domain Subtypes
  74. Curved EFC/F-BAR-Domain Dimers Are Joined End to End into a Filament for Membrane Invagination in Endocytosis
  75. Purification, crystallization and preliminary X-ray diffraction analysis of the non-ATPase subunit Nas6 in complex with the ATPase subunit Rpt3 of the 26S proteasome fromSaccharomyces cerevisiae
  76. Crystal Structure of the Human BRD2 Bromodomain
  77. Structure of the Oncoprotein Gankyrin in Complex with S6 ATPase of the 26S Proteasome
  78. Crystallization of the archaeal transcription termination factor NusA: a significant decrease in twinning under microgravity conditions
  79. Solution structure of an atypical WW domain in a novel β‐clam‐like dimeric form
  80. Photo-Cross-Linked Small-Molecule Microarrays as Chemical Genomic Tools for Dissecting Protein–Ligand Interactions
  81. Structure of the UNC5H2 death domain
  82. Solution Structures of the SURP Domains and the Subunit-Assembly Mechanism within the Splicing Factor SF3a Complex in 17S U2 snRNP
  83. Solution structure of the kinase‐associated domain 1 of mouse microtubule‐associated protein/microtubule affinity‐regulating kinase 3
  84. The Crystal Structure of Mouse Nup35 Reveals Atypical RNP Motifs and Novel Homodimerization of the RRM Domain
  85. Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells
  86. Crystal Structure of the RUN Domain of the RAP2-interacting Protein x
  87. Solution structure of the antifreeze‐like domain of human sialic acid synthase
  88. An Arabidopsis SBP‐domain fragment with a disrupted C‐terminal zinc‐binding site retains its tertiary structure
  89. Solution Structure of the SWIRM Domain of Human Histone Demethylase LSD1
  90. Purification, crystallization and preliminary X-ray diffraction analysis of the histone chaperone cia1 from fission yeast
  91. Solution Structure of the Major DNA-binding Domain of Arabidopsis thaliana Ethylene-insensitive3-like3
  92. Crystal structure of the N-terminal RecA-like domain of a DEAD-box RNA helicase, the Dugesia japonica vasa-like gene B protein
  93. Solution structure of the Src homology 2 domain from␣the human feline sarcoma oncogene Fes
  94. Simultaneous operation of off pump coronary artery bypass and abdominal aortic aneurysm repair
  95. Solution Structure of an Arabidopsis WRKY DNA Binding Domain
  96. Solution structure of the PWWP domain of the hepatoma‐derived growth factor family
  97. Solution structure of the rhodanese homology domain At4g01050(175–295) from Arabidopsis thaliana
  98. Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1
  99. Letter to the Editor: NMR assignment of the SH2 domain from the human feline sarcoma oncogene FES
  100. Solution Structure of the B3 DNA Binding Domain of the Arabidopsis Cold-Responsive Transcription Factor RAV1[W]
  101. In situ detection of acetylaminofluorene–DNA adducts in human cells using monoclonal antibodies
  102. The CAP-Gly Domain of CYLD Associates with the Proline-Rich Sequence in NEMO/IKKγ
  103. Solution structure of the RWD domain of the mouse GCN2 protein
  104. Letter to the Editor: NMR assignment of the hypothetical ENTH-VHS domain At3g16270 from Arabidopsis thaliana
  105. Letter to the Editor: NMR assignment of the hypothetical rhodanese domain At4g01050 from Arabidopsis thaliana
  106. A Novel Zinc-binding Motif Revealed by Solution Structures of DNA-binding Domains of Arabidopsis SBP-family Transcription Factors
  107. Preparation of Escherichia coli cell extract for highly productive cell-free protein expression
  108. Antisense p53 RNA Abrogates Antisense Rb RNA-Induced Cell Death in Mouse Fibroblast SV-T2 Cells.
  109. Apoptosis Was Promoted at a Nonpermissive Temperature in DNA Replication-Defective Temperature-Sensitive Mutants of Mouse FM3A Cells
  110. Sensitive Detection of Rodent Rb Protein by Polyclonal Antibodies Against a Bacterially Expressed Mouse Rb Protein.
  111. Improved Dicistronic mRNA Expression Vectors for Efficient Selection of Transfectants Highly Expressing Foreign Genes
  112. Application of a Dicistronic mRNA Expression Vector to Antisense RNA Expression in Mammalian Cells
  113. Temperature-sensitive Mutation of DNA Polymerase .ALPHA. Induces Growth-suppressive Phenotypes Involving Retinoblastoma Protein and Cyclin D1.
  114. Assignment of ESR signals of Escherichia coli terminal oxidase complexes