All Stories

  1. Synthesis of Cyclobuta[cd]pentalenes via an Intramolecular Double Michael Addition Reaction of 1,3-Cyclopentanedione Derivatives
  2. Correction to “Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation”
  3. Asymmetric Total Synthesis of Cytotrienin A: Late‐Stage Installation of C11 Side Chain onto the Macrolactam Scaffold
  4. Asymmetric Total Synthesis of Cytotrienin A: Late‐Stage Installation of C11 Side Chain onto the Macrolactam Scaffold
  5. Cis-Selective Double Spirocyclization via Dearomatization and Isomerization under Thermodynamic Control
  6. Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation
  7. A chalcone derivative suppresses TSLP induction in mice and human keratinocytes through binding to BET family proteins
  8. Toward the Creation of Induced Pluripotent Small (iPS) Molecules: Establishment of a Modular Synthetic Strategy for the Heronamide C-type Polyene Macrolactams and Their Conformational and Reactivity Analysis
  9. Design, Synthesis, and Antifungal Activity of 16,17-Dihydroheronamide C and ent-Heronamide C
  10. Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation
  11. Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation
  12. Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation
  13. Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation
  14. Design, Synthesis and Biological Activity of 16,17-Dihydroheronamide C and ent-Heronamide C
  15. Design, Synthesis and Biological Activity of 16,17-Dihydroheronamide C and ent-Heronamide C
  16. Toward the Creation of Induced Pluripotent Small (iPS) Molecules: Establishment of a Modular Synthetic Strategy to the Heronamide C-type Polyene Macrolactams and Their Conformational and Reactivity Analysis
  17. Toward the Creation of Induced Pluripotent Small (iPS) Molecules: Establishment of a Modular Synthetic Strategy to the Heronamide C-type Polyene Macrolactams and Their Conformational and Reactivity Analysis
  18. Design, Synthesis and Biological Activity of 16,17-Dihydroheronamide C and ent-Heronamide C
  19. Design, Synthesis and Biological Activity of 16,17-Dihydroheronamide C and ent-Heronamide C
  20. Toward the Creation of Induced Pluripotent Small (iPS) Molecules: Establishment of a Modular Synthetic Strategy to the Heronamide C-type Polyene Macrolactams and Their Conformational and Reactivity Analysis
  21. Toward the Creation of Induced Pluripotent Small (iPS) Molecules: Establishment of a Modular Synthetic Strategy to the Heronamide C-type Polyene Macrolactams and Their Conformational and Reactivity Analysis
  22. Synthetic Access to gem-Difluoropropargyl Vinyl Ethers and Their Application to Propargyl Claisen Rearrangement
  23. Front Cover: Rapid Access to Dispirocyclic Scaffolds Enabled by Diastereoselective Intramolecular Double Functionalization of Benzene Rings (Chem. Asian J. 24/2020)
  24. Rapid Access to Dispirocyclic Scaffolds Enabled by Diastereoselective Intramolecular Double Functionalization of Benzene Rings
  25. An integrated screening system for the selection of exemplary substrates for natural and engineered cytochrome P450s
  26. Highly Chemoselective gem‐Difluoropropargylation of Aliphatic Alcohols
  27. Gold(i)-catalyzed Nicholas reaction with aromatic molecules utilizing a bifunctional propargyl dicobalt hexacarbonyl complex
  28. Stereocontrolled Construction of ABCD Tetracyclic Ring System with Vicinal All-Carbon Quaternary Stereogenic Centers of Calyciphylline A Type Alkaloids
  29. Nazarov Cyclization Entry to Chiral Bicyclo[5.3.0]decanoid Building Blocks and Its Application to Formal Synthesis of (−)-Englerin A
  30. Substrate Recognition by a Dual‐Function P450 Monooxygenase GfsF Involved in FD‐891 Biosynthesis
  31. A mild two-step propargylation of aromatic bioactive small molecules
  32. Concise, Protecting-Group-Free Synthesis of (+)-Nemonapride <i>via</i> Eu(OTf)<sub>3</sub>-Catalyzed Aminolysis of 3,4-Epoxy Alcohol
  33. Design and synthesis of the penta(acetoxymethyl) ester of dioctanoyl phosphatidylinositol-3,5-bisphosphate
  34. Asymmetric Total Synthesis of Heronamides A–C: Stereochemical Confirmation and Impact of Long‐Range Stereochemical Communication on the Biological Activity
  35. Vicenistatin induces early endosome-derived vacuole formation in mammalian cells
  36. An enantiocontrolled entry to the tricyclic polar segment of (+)-fusarisetin A
  37. Synthesis and structure–activity relationship study of FD-891: importance of the side chain and C8–C9 epoxide for cytotoxic activity against cancer cells
  38. Photo-cross-linked small-molecule affinity matrix as a tool for target identification of bioactive small molecules
  39. Reversibility of the thia-Michael reaction of cytotoxic C5-curcuminoid and structure–activity relationship of bis-thiol-adducts thereof
  40. Total Synthesis of the Proposed Structure of Turkiyenine
  41. Total Synthesis and Biological Evaluation of Irciniastatin A (a.k.a. Psymberin) and Irciniastatin B
  42. Structure-Activity Relationships of the Antitumor C5-Curcuminoid GO-Y030
  43. Third Generation Photo-Cross-Linked Small-Molecule Affinity Matrix: A Photoactivatable and Photocleavable System Enabling Quantitative Analysis of the Photo-Cross-Linked Small Molecules and Their Target Purification
  44. Irciniastatin A, a pederin-type translation inhibitor, promotes ectodomain shedding of cell-surface tumor necrosis factor receptor 1
  45. ChemInform Abstract: Total Synthesis of the Proposed Structure of Heronamide C.
  46. Structure-Function Analyses of Cytochrome P450revI Involved in Reveromycin A Biosynthesis and Evaluation of the Biological Activity of Its Substrate, Reveromycin T
  47. A Concise and Unified Strategy for Synthesis of the C1–C18 Macrolactone Fragments of FD-891, FD-892 and Their Analogues: Formal Total Synthesis of FD-891
  48. Eu(OTf) 3 -Catalyzed Highly Regioselective Nucleophilic Ring Opening of 2,3-Epoxy Alcohols: An Efficient Entry to 3-Substituted 1,2-Diol Derivatives
  49. ChemInform Abstract: Enantioselective Intramolecular Aza-Spiroannulation onto Benzofurans Using Chiral Rhodium Catalysis.
  50. Total Synthesis of the Proposed Structure of Heronamide C
  51. Enantioselective Intramolecular Aza-Spiroannulation onto Benzofurans Using Chiral Rhodium Catalysis
  52. On the Origin of cine-Substitution in the Stille Coupling of Trisubstituted Iodoalkene and trans-Vinylstannane
  53. Dual Structure–Activity Relationship of Osteoclastogenesis Inhibitor Methyl Gerfelin Based on TEG Scanning
  54. An improved fluorogenic NAD(P)+ detection method using 2-acetylbenzofuran: its origin and application
  55. Synthesis and Structure-Activity Relationship of Vicenistatin, a Cytotoxic 20-Membered Macrolactam Glycoside
  56. Corrigendum: Detection of Cytochrome P450 Substrates by Using a Small-Molecule Droplet Array on an NADH-Immobilized Solid Surface
  57. Detection of Cytochrome P450 Substrates by Using a Small-Molecule Droplet Array on an NADH-Immobilized Solid Surface
  58. Preparation of Photo-Cross-Linked Small Molecule Affinity Matrices for Affinity Selection of Protein Targets for Biologically Active Small Molecules
  59. Concise Entry to Both Enantiomers of 8-Oxabicyclo[3.2.1]oct-3-en-2-one Based on Novel Oxidative Etherification: Formal Synthesis of (+)-Sundiversifolide
  60. Asymmetric Total Synthesis of (−)-Scabronine G via Intramolecular Double Michael Reaction and Prins Cyclization
  61. ChemInform Abstract: An Enantio- and Diastereocontrolled Synthesis of (-)-Salinosporamide A (X).
  62. ChemInform Abstract: Organic Chemistry at the Interface of Complex Bioactive Natural Product and Chemical Biology
  63. Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway
  64. Concise Total Synthesis of Vicenistatin
  65. KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue
  66. ChemInform Abstract: Syntheses and Biological Evaluation of Irciniastatin A and the C1-C2 Alkyne Analogue.
  67. ChemInform Abstract: Total Synthesis and Determination of the Absolute Configuration of (-)-Idesolide.
  68. ChemInform Abstract: Synthetic Studies on Azadirachtin: Construction of the Highly Functionalized Decalin Moiety of Azadirachtin.
  69. ChemInform Abstract: Total Synthesis of (-)-Penitrem D.
  70. ChemInform Abstract: Synthetic Studies on Azadirachtin: Asymmetric Synthesis of the Tetracyclic Decalin Part (I) of Azadirachtin.
  71. ChemInform Abstract: Synthetic Studies on Azadirachtin: An Efficient Asymmetric Synthesis of the Highly Functionalized Tricyclic Decalin Part of Azadirachtin.
  72. ChemInform Abstract: Synthetic Studies on Altohyrtins (Spongistatins): Synthesis of the C29-C44 (EF) Portion.
  73. ChemInform Abstract: Highly Enantioselective Intramolecular Aza-Spiroannulation onto Indoles Using Chiral Rhodium Catalysis: Asymmetric Entry to the Spiro-β-lactam Core of Chartellines.
  74. Total Synthesis and Determination of the Absolute Configuration of (−)-Idesolide
  75. Syntheses and Biological Evaluation of Irciniastatin A and the C1−C2 Alkyne Analogue
  76. Structure–activity relationship of C5-curcuminoids and synthesis of their molecular probes thereof
  77. Cleavable Linker for Photo-Cross-Linked Small-Molecule Affinity Matrix
  78. Construction of Photo-Cross-Linked Microarrays of Small Molecules
  79. An Enantio- and Diastereocontrolled Synthesis of (–)-Salinosporamide A
  80. Organic Chemistry at the Interface of Complex Bioactive Natural Product and Chemical Biology
  81. An Expedient Route to a Potent Gastrin/CCK-B Receptor Antagonist (+)-AG-041R
  82. Synthetic Studies on Daphnicyclidin A: Enantiocontrolled Construction of the BCD Ring System
  83. Structure-Affinity Relationship Study of Bleomycins and ShbleProtein by Use of a Chemical Array
  84. ChemInform Abstract: Efficient Entry to the Pyrroloquinoline Core of Martinella Alkaloids via Novel Base-Catalyzed Mukaiyama-Mannich Reaction.
  85. Total Synthesis of Methyl Sarcophytoate, a Marine Natural Biscembranoid
  86. Syntheses of naturally occurring cytotoxic [7.7]paracyclophanes, (−)-cylindrocyclophane A and its enantiomer, and implications for biological activity
  87. Highly enantioselective intramolecular aza-spiroannulation onto indoles using chiral rhodium catalysis: asymmetric entry to the spiro-β-lactam core of chartellines
  88. The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I
  89. Synthesis and biological activities of reveromycin A and spirofungin A derivatives
  90. Distribution of photo-cross-linked products from 3-aryl-3-trifluoromethyldiazirines and alcohols
  91. Efficient Entry to the Pyrroloquinoline Core of Martinella Alkaloids via Novel Base-catalyzed Mukaiyama–Mannich Reaction
  92. Total Synthesis of Methyl Sarcophytoate.
  93. Synthesis of Methyl Sarcophytoate
  94. Total Synthesis of Methyl Sarcophytoate
  95. Photo-Cross-Linked Small-Molecule Microarrays as Chemical Genomic Tools for Dissecting Protein–Ligand Interactions
  96. Small-Molecule Microarrays as Tools for Facilitating Chemical Genomics: Recent Advances
  97. SPR Imaging of Photo-Cross-Linked Small-Molecule Arrays on Gold
  98. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts
  99. ケミカルゲノミクス研究用ツールとしての低分子有機化合物のマイクロアレイ化技術
  100. Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics
  101. Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics
  102. Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics
  103. Photo‐Cross‐Linked Small‐Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics
  104. Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells
  105. Synthetic studies on biscembranoids: asymmetric total synthesis of methyl sarcoate
  106. Oxidative Deprotection of 1,3-Dithiane Group Using NaClO2 and NaH2PO4 in Aqueous Methanol.
  107. The Anticancer Natural Product Pironetin Selectively Targets Lys352 of α-Tubulin
  108. Formal Total Synthesis of Altohyrtin C (I) (Spongistatin 2). Part 1. Aldol Approach to Unite AB (II) and CD (III) Spiroacetals.
  109. Oxidative Deprotection of 1,3-Dithiane Group Using NaClO 2 and NaH 2 PO 4 in Aqueous Methanol
  110. Immobilization of Natural Products on Glass Slides by Using a Photoaffinity Reaction and the Detection of Protein–Small-Molecule Interactions
  111. Immobilization of Natural Products on Glass Slides by Using a Photoaffinity Reaction and the Detection of Protein–Small-Molecule Interactions
  112. Formal total synthesis of altohyrtin C (spongistatin 2). Part 1: Aldol approach to unite AB and CD spiroacetals
  113. Formal total synthesis of altohyrtin C (spongistatin 2). Part 2: Construction of fully elaborated ABCD and EF fragments
  114. Tremorgenic Indole Alkaloids. The Total Synthesis of (−)-Penitrem D
  115. Practical deracemization of NM-3, a synthetic angiogenesis inhibitor
  116. Studies Aimed at the Total Synthesis of Azadirachtin. A Modeled Connection of C-8 and C-14 in Azadirachtin
  117. Synthetic studies on altohyrtins (spongistatins): synthesis of the C29–C44 (EF) portion
  118. Total Synthesis of (−)-Penitrem D
  119. Synthetic studies on altohyrtins (spongistatins): synthesis of the C15–C28 (CD) spiroacetal portion
  120. Synthetic Studies on Azadirachtin: Asymmetric Synthesis of the Tetracyclic Decalin Part of Azadirachtin
  121. Synthetic Studies on Azadirachtin: An Efficient Asymmetric Synthesis of the Highly Functionalized Tricyclic Decalin Part of Azadirachtin
  122. Tremorgenic Indole Alkaloids. Studies Directed toward the Assembly of the A, F, and I Rings of Penitrem D:  Observation of an Unexpected Stereochemical Outcome
  123. Synthetic studies on azadirachtin: Construction of the highly functionalized decalin moiety of azadirachtin
  124. Synthetic Study on Azadirachtin: Asymmetric Synthesis of the Tetracyclic Decalin Part of Azadirachtin
  125. Conversion of prelaureatin into laurallene, a bromo-allene compound, by enzymatic and chemical bromo-etherification reactions
  126. Construction of the Tricyclic trans-Decalin Framework of Azadirachtins via Intramolecular Diels-Alder Reaction
  127. Enzymatic reaction of (3E,6S,7S)-laurediol and the molecular modeling studies on the cyclization of laurediols
  128. Isomerization of the (Z)-Enyne Unit to the (E)-Enyne Unit. Conversion of Laureatin to (E)-Isolaureatin.
  129. Recent Developments and Advances in Chemical Arrays