All Stories

  1. Genomic and transcriptomic characterization of the mitochondrial-rich oncocytic phenotype on a thyroid carcinoma background

    Article • Mitochondrion, April 2018, Elsevier

    Valdemar Máximo, Paula Soares

  2. Dynamin-Related Protein 1 at the Crossroads of Cancer

    Article • Genes, February 2018, MDPI AG

    Valdemar Máximo, Paula Soares

  3. Etiopathogenesis of oncocytomas

    Article • Seminars in Cancer Biology, December 2017, Elsevier

    Valdemar Máximo, Paula Soares

  4. Telomerase and N-Cadherin in Adrenocortical Tumors

    Article • Journal of Cellular Biochemistry, April 2017, Wiley

    Duarte Pignatelli, Valdemar Máximo, Paula Soares, Susana Gomes Gomes Guerreiro

  5. An overview on the role of autophagy in cancer therapy

    Article • Hematology & Medical Oncology, January 2017, Open Access Text Pvt, Ltd.

    Valdemar Máximo

  6. The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism

    Article • International Journal of Cancer, March 2016, Wiley

    Valdemar Máximo, Paula Soares, MD, PhD José Manuel Lopes

  7. Thyroid and Parathyroid Glands

    Article • January 2016, Springer Science + Business Media

    Valdemar Máximo, Paula Soares

  8. STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment

    Article • Tumor Biology, November 2015, Springer Science + Business Media

    Valdemar Máximo

  9. A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy

    Article • The Journal of Pathology, July 2015, Wiley

    Valdemar Máximo, Dr. Fatima Baltazar

  10. Overexpression of pyruvate dehydrogenase kinase supports dichloroacetate as a candidate for cutaneous melanoma therapy

    Article • Expert Opinion on Therapeutic Targets, May 2015, Informa Healthcare

    Valdemar Máximo, Paula Soares, MD, PhD José Manuel Lopes

  11. Mitochondrial Dynamics Protein Drp1 Is Overexpressed in Oncocytic Thyroid Tumors and Regulates Cancer Cell Migration

    Article • PLoS ONE, March 2015, PLOS

    Valdemar Máximo, Paula Soares

  12. Loss of Mitochondrial SDHB Expression: What is its Role in Diffuse Thyroid Lipomatosis?

    Article • Hormone and Metabolic Research, February 2015, Thieme Publishing Group

    Valdemar Máximo

  13. OXPHOS dysfunction regulates integrin- 1 modifications and enhances cell motility and migration

    Article • Human Molecular Genetics, December 2014, Oxford University Press (OUP)

    Valdemar Máximo, Paula Soares

  14. Telomerase promoter mutations in cancer: an emerging molecular biomarker?

    Article • Virchows Archiv, July 2014, Springer Science + Business Media

    Valdemar Máximo, Paula Soares, MD, PhD José Manuel Lopes

  15. TERT Promoter Mutations Are a Major Indicator of Poor Outcome in Differentiated Thyroid Carcinomas

    Article • The Journal of Clinical Endocrinology & Metabolism, May 2014, Endocrine Society

    Valdemar Máximo, Paula Soares

  16. Mitochondria dynamism: of shape, transport and cell migration

    Article • Cellular and Molecular Life Sciences, January 2014, Springer Science + Business Media

    Valdemar Máximo

  17. Oncocytic Lesions of the Thyroid, Kidney, Salivary Glands, Adrenal Cortex, and Parathyroid Glands

    Article • International Journal of Surgical Pathology, January 2014, SAGE Publications

    Valdemar Máximo

  18. Mitochondrial D310 D-Loop instability and histological subtypes in radiation-induced cutaneous basal cell carcinomas

    Article • Journal of Dermatological Science, January 2014, Elsevier

    Valdemar Máximo, Paula Soares, MD, PhD José Manuel Lopes

  19. A founder SDHB mutation in Portuguese paraganglioma patients

    Article • October 2013, Bioscientifica

    Valdemar Máximo, Paula Soares

  20. Frequency of TERT promoter mutations in human cancers

    Article • Nature Communications, July 2013, Springer Science + Business Media

    Professor Luis Lima, Valdemar Máximo, Paula Soares, MD, PhD José Manuel Lopes

  21. Molecular alterations and expression of succinate dehydrogenase complex in wild-type KIT/PDGFRA/BRAF gastrointestinal stromal tumors

    Article • European Journal of Human Genetics, September 2012, Nature

    Valdemar Máximo, Paula Soares, MD, PhD José Manuel Lopes

  22. STAT3 negatively regulates thyroid tumorigenesis

    Article • Proceedings of the National Academy of Sciences, August 2012, Proceedings of the National Academy of Sciences

    Valdemar Máximo, Paula Soares

  23. RET/PTCrearrangement is prevalent in follicular Hürthle cell carcinomas

    Article • Histopathology, July 2012, Wiley

    Valdemar Máximo, Paula Soares

  24. The biology and the genetics of Hurthle cell tumors of the thyroid

    Article • April 2012, Bioscientifica

    Valdemar Máximo, Paula Soares

  25. Absence of theBRAFand theGRIM-19Mutations in Oncocytic (Hürthle Cell) Solid Cell Nests of the Thyroid

    Article • American Journal of Clinical Pathology, April 2012, Oxford University Press (OUP)

    Valdemar Máximo, Paula Soares

  26. Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

    Article • BMC Cancer, February 2012, Springer Science + Business Media

    Valdemar Máximo

  27. A novel germline SDHB mutation in a gastrointestinal stromal tumor patient without bona fide features of the Carney–Stratakis dyad

    Article • Familial Cancer, December 2011, Springer Science + Business Media

    Valdemar Máximo, Paula Soares, MD, PhD José Manuel Lopes

  28. Genetic Alterations in Poorly Differentiated and Undifferentiated Thyroid Carcinomas

    Article • Current Genomics, December 2011, Bentham Science Publishers

    Valdemar Máximo, Paula Soares

  29. GRIM-19 function in cancer development

    Article • Mitochondrion, September 2011, Elsevier

    Valdemar Máximo, Paula Soares

  30. Orthovanadate-induced cell death in RET/PTC1-harboring cancer cells involves the activation of caspases and altered signaling through PI3K/Akt/mTOR

    Article • Life Sciences, September 2011, Elsevier

    Valdemar Máximo, Paula Soares

  31. Synergistic growth inhibition of cancer cells harboring the RET/PTC1 oncogene by staurosporine and rotenone involves enhanced cell death

    Article • Journal of Biosciences, September 2011, Springer Science + Business Media

    Valdemar Máximo, Paula Soares

  32. Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, March 2011, Elsevier

    Valdemar Máximo, Paula Soares

  33. An assessment of the clonality of the components of canine mixed mammary tumours by mitochondrial DNA analysis

    Article • The Veterinary Journal, November 2009, Elsevier

    Valdemar Máximo, Paula Soares

  34. The Diversity Present in 5140 Human Mitochondrial Genomes

    Article • The American Journal of Human Genetics, May 2009, Elsevier

    Valdemar Máximo

  35. Helicobacter pylori Infection Induces Genetic Instability of Nuclear and Mitochondrial DNA in Gastric Cells

    Article • Clinical Cancer Research, April 2009, American Association for Cancer Research (AACR)

    Valdemar Máximo

  36. Mitochondria and cancer

    Article • Virchows Archiv, April 2009, Springer Science + Business Media

    Valdemar Máximo, Paula Soares

  37. How molecular pathology is changing and will change the therapeutics of patients with follicular cell-derived thyroid cancer

    Article • Journal of Clinical Pathology, January 2009, BMJ

    Valdemar Máximo, Paula Soares

  38. Mitochondria and Oncocytomas

    Article • December 2008, Springer Science + Business Media

    Valdemar Máximo, Paula Soares

  39. Optimization of methods to assess mitochondrial DNA in archival paraffin-embedded tissues from mammary canine tumors

    Article • Jornal Brasileiro de Patologia e Medicina Laboratorial, August 2008, FapUNIFESP (SciELO)

    Valdemar Máximo, Paula Soares

  40. Intragenic Mutations in Thyroid Cancer

    Article • Endocrinology and Metabolism Clinics of North America, June 2008, Elsevier

    Valdemar Máximo, Paula Soares

  41. GRIM-19 mutations are not associated with Crohnʼs disease

    Article • Inflammatory Bowel Diseases, March 2008, Wolters Kluwer Health

    Valdemar Máximo

  42. GRIM-19 in Health and Disease

    Article • Advances in Anatomic Pathology, January 2008, Wolters Kluwer Health

    Valdemar Máximo, Paula Soares

  43. High Frequency of Germline Succinate Dehydrogenase Mutations in Sporadic Cervical Paragangliomas in Northern Spain: Mitochondrial Succinate Dehydrogenase Structure-Function Relationships and Clinical-Pathological Correlations

    Article • The Journal of Clinical Endocrinology & Metabolism, December 2007, Endocrine Society

    Valdemar Máximo

  44. Molecular and Genotypic Characterization of Human Thyroid Follicular Cell Carcinoma–Derived Cell Lines

    Article • Thyroid, August 2007, Mary Ann Liebert Inc

    Valdemar Máximo, Paula Soares

  45. Molecular genetics of papillary thyroid carcinoma: great expectations...

    Article • Arquivos Brasileiros de Endocrinologia & Metabologia, July 2007, FapUNIFESP (SciELO)

    Valdemar Máximo

  46. Warthin's tumour

    Article • Virchows Archiv, April 2006, Springer Science + Business Media

    Valdemar Máximo

  47. Reply to: Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas

    Article • Cancer Letters, December 2005, Elsevier

    Valdemar Máximo, Paula Soares

  48. Mitochondrial D-Loop instability in thyroid tumours is not a marker of malignancy

    Article • Mitochondrion, October 2005, Elsevier

    Valdemar Máximo, Paula Soares

  49. Molecular pathology of well-differentiated thyroid carcinomas

    Article • Virchows Archiv, September 2005, Springer Science + Business Media

    Valdemar Máximo, Paula Soares

  50. Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients’ age but not with tumour aggressiveness

    Article • Virchows Archiv, May 2005, Springer Science + Business Media

    Valdemar Máximo, Paula Soares

  51. Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumours of the thyroid

    Article • British Journal of Cancer, April 2005, Nature

    Valdemar Máximo, Paula Soares

  52. Hürthle (Oncocytic) Cell Tumors of Thyroid: Etiopathogenesis, Diagnosis and Clinical Significance

    Article • International Journal of Surgical Pathology, January 2005, SAGE Publications

    Valdemar Máximo

  53. BRAFMutations Are Not a Major Event in Post-Chernobyl Childhood Thyroid Carcinomas

    Article • The Journal of Clinical Endocrinology & Metabolism, September 2004, Endocrine Society

    Valdemar Máximo, Paula Soares

  54. Core I gene is overexpressed in Hürthle and non-Hürthle cell microfollicular adenomas and follicular carcinomas of the thyroid

    Article • BMC Cancer, March 2004, Springer Science + Business Media

    Valdemar Máximo, Paula Soares

  55. BRAF mutations are associated with some histological types of papillary thyroid carcinoma

    Article • The Journal of Pathology, January 2004, Wiley

    Valdemar Máximo, Paula Soares

  56. Germline Succinate Dehydrogenase Subunit D Mutation Segregating with Familial Non-RET C Cell Hyperplasia

    Article • The Journal of Clinical Endocrinology & Metabolism, October 2003, Endocrine Society

    Valdemar Máximo, Paula Soares

  57. BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC

    Article • Oncogene, July 2003, Nature

    Valdemar Máximo, Paula Soares

  58. Letter to the editor

    Article • Genes Chromosomes and Cancer, January 2003, Wiley

    Valdemar Máximo

  59. Mucoepidermoid carcinoma of the thyroid: a tumour histotype characterised by P-cadherin neoexpression and marked abnormalities of E-cadherin/catenins complex

    Article • Virchows Archiv, May 2002, Springer Science + Business Media

    Valdemar Máximo, Paula Soares

  60. Microsatellite instability, mitochondrial DNA large deletions, and mitochondrial DNA mutations in gastric carcinoma

    Article • Genes Chromosomes and Cancer, August 2001, Wiley

    Valdemar Máximo, Paula Soares

  61. Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant

    Article • The Journal of Pathology, May 2001, Wiley

    Valdemar Máximo, Paula Soares

  62. Mitochondrial DNA ‘common’ deletion in Hürthle cell lesions of the thyroid

    Article • The Journal of Pathology, December 2000, Wiley

    Valdemar Máximo

  63. Mitochondrial DNA alteration in gastric cancer

    Article • Gastroenterology, December 2000, Elsevier

    Valdemar Máximo

  64. A new PKLR gene mutation in the R-type promoter region affects the gene transcription causing pyruvate kinase deficiency

    Article • British Journal of Haematology, September 2000, Wiley

    Valdemar Máximo

  65. Hürthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance

    Article • Virchows Archiv, August 2000, Springer Science + Business Media

    Valdemar Máximo

  66. Comments on: Mutations in Mitochondrial Control Region DNA in Gastric Tumours of Japanese Patients, Tamura, et al. Eur J Cancer 1999, 35, 316–319

    Article • European Journal of Cancer, September 1999, Elsevier

    Valdemar Máximo, Paula Soares

  67. The Common Deletion of Mitochondrial DNA is Found in Goiters and Thyroid Tumors with and Without Oxyphil Cell Change

    Article • Ultrastructural Pathology, January 1998, Taylor & Francis

    Valdemar Máximo