All Stories

  1. A preliminary assessment of a stool-based microRNA profile for early colorectal cancer screening

    Article • Scientific Reports, August 2025, Springer Science + Business Media

    Professor Luis Lima

  2. Exosome-derived hsa-miR-200c-3p, hsa-miR-25-3p and hsa-miR-301a-3p as potential biomarkers and therapeutic targets for restoration of PTEN expression in clear cell renal cell carcinoma

    Article • International Journal of Biological Macromolecules, April 2025, Elsevier

    Professor Luis Lima

  3. Advancing Non-Invasive Colorectal Cancer Screening: Exploring the Potential of Monoclonal Antibody L2A5

    Article • International Journal of Molecular Sciences, March 2025, MDPI AG

    Paula Videira, Professor Luis Lima

  4. Multilevel plasticity and altered glycosylation drive aggressiveness in hypoxic and glucose-deprived bladder cancer cells

    Article • iScience, February 2025, Elsevier

    Professor Luis Lima

  5. ABCB1 C1236T, G2677TA and C3435T Genetic Polymorphisms and Antidepressant Response Phenotypes: Results from a Portuguese Major Depressive Disorder Cohort

    Article • International Journal of Molecular Sciences, May 2024, MDPI AG

    Professor Luis Lima

  6. Stool Glycoproteomics Signatures of Pre-Cancerous Lesions and Colorectal Cancer

    Article • International Journal of Molecular Sciences, March 2024, MDPI AG

    Professor Luis Lima

  7. Aberrantly Glycosylated GLUT1 as a Poor Prognosis Marker in Aggressive Bladder Cancer

    Article • International Journal of Molecular Sciences, March 2024, MDPI AG

    Professor Luis Lima

  8. Minimizing false positives for CTC identification

    Article • Analytica Chimica Acta, February 2024, Elsevier

    Professor Luis Lima

  9. Multilevel Plasticity and Altered Glycosylation Drive Aggressiveness in Hypoxic and Glucose-Deprived Bladder Cancer Cells

    Article • October 2023, Cold Spring Harbor Laboratory Press

    Filipe Teixeira, Professor Luis Lima

  10. MicroRNA Biomarkers as Promising Tools for Early Colorectal Cancer Screening—A Comprehensive Review

    Article • International Journal of Molecular Sciences, July 2023, MDPI AG

    Professor Luis Lima

  11. Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival

    Article • Proceedings of the National Academy of Sciences, May 2023, Proceedings of the National Academy of Sciences

    Professor Luis Lima

  12. Discriminating Epithelial to Mesenchymal Transition Phenotypes in Circulating Tumor Cells Isolated from Advanced Gastrointestinal Cancer Patients

    Article • Cells, January 2022, MDPI AG

    Professor Luis Lima

  13. Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion

    Article • Theranostics, January 2022, Ivyspring International Publisher

    Professor Luis Lima

  14. Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer

    Article • Journal of Experimental & Clinical Cancer Research, June 2021, Springer Science + Business Media

    Professor Luis Lima

  15. Profiling DNA mutation patterns by SERS fingerprinting for supervised cancer classification

    Article • Biosensors and Bioelectronics, October 2020, Elsevier

    Professor Luis Lima

  16. Phenotypic Analysis of Urothelial Exfoliated Cells in Bladder Cancer via Microfluidic Immunoassays: Sialyl-Tn as a Novel Biomarker in Liquid Biopsies

    Article • Frontiers in Oncology, September 2020, Frontiers

    Professor Luis Lima

  17. TERT Promoter Mutation as a Potential Predictive Biomarker in BCG-Treated Bladder Cancer Patients

    Article • International Journal of Molecular Sciences, January 2020, MDPI AG

    Paula Soares, Professor Luis Lima

  18. Exploring sialyl-Tn expression in microfluidic-isolated circulating tumour cells: A novel biomarker and an analytical tool for precision oncology applications

    Article • New Biotechnology, March 2019, Elsevier

    Professor Luis Lima, Paula Videira

  19. Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2–6 sialic acids

    Article • Scientific Reports, August 2018, Springer Science + Business Media

    Professor Luis Lima, Paula Videira

  20. Glycan affinity magnetic nanoplatforms for urinary glycobiomarkers discovery in bladder cancer

    Article • Talanta, July 2018, Elsevier

    Professor Luis Lima

  21. CD44 glycoprotein in cancer: a molecular conundrum hampering clinical applications

    Article • Clinical Proteomics, June 2018, Springer Science + Business Media

    Professor Luis Lima

  22. Circulating tumor cells in bladder cancer: Emerging technologies and clinical implications foreseeing precision oncology

    Article • Urologic Oncology Seminars and Original Investigations, May 2018, Elsevier

    Professor Luis Lima

  23. Over forty years of bladder cancer glycobiology: Where do glycans stand facing precision oncology?

    Article • Oncotarget, July 2017, Impact Journals, LLC

    Professor Luis Lima

  24. TargetedO-glycoproteomics explored increased sialylation and identified MUC16 as a poor prognosis biomarker in advanced-stage bladder tumours

    Article • Molecular Oncology, March 2017, Wiley

    Professor Luis Lima

  25. Reference Genes for Addressing Gene Expression of Bladder Cancer Cell Models under Hypoxia: A Step Towards Transcriptomic Studies

    Article • PLOS One, November 2016, PLOS

    Professor Luis Lima

  26. IL6-174G > C genetic polymorphism influences antidepressant treatment outcome

    Article • Nordic Journal of Psychiatry, October 2016, Taylor & Francis

    Professor Luis Lima

  27. Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension

    Article • Oncotarget, September 2016, Impact Journals, LLC

    Filipe Teixeira, Professor Luis Lima

  28. The role of IL18-607C > A and IL18-137G > C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report

    Article • Neuroscience Letters, May 2016, Elsevier

    Professor Luis Lima

  29. Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics

    Article • PLOS One, November 2015, PLOS

    Professor Luis Lima

  30. FAS -670A>G genetic polymorphism Is associated with Treatment Resistant Depression

    Article • Journal of Affective Disorders, October 2015, Elsevier

    Professor Luis Lima

  31. New trends in guided nanotherapies for digestive cancers: A systematic review

    Article • Journal of Controlled Release, July 2015, Elsevier

    Professor Luis Lima

  32. The role of functional polymorphisms in immune response genes as biomarkers of bacille Calmette-Guérin (BCG) immunotherapy outcome in bladder cancer: establishment of a predictive profile in a Southern Europe population

    Article • BJU International, May 2015, Wiley

    Professor Luis Lima

  33. Su1939 Influence of Genetic Polymorphisms in Prostaglandin E2 (PGE2) Pathway on mRNA Expression of COX-2, Hpgd, Abcc4 and Slco2a1 Genes in Colorectal Tumors

    Article • Gastroenterology, April 2015, Elsevier

    Professor Luis Lima

  34. P53 and Cancer-Associated Sialylated Glycans Are Surrogate Markers of Cancerization of the Bladder Associated with Schistosoma haematobium Infection

    Article • PLoS Neglected Tropical Diseases, December 2014, PLOS

    Professor Luis Lima

  35. The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladder tumors is associated with BCG immunotherapy failure11The first author has a PhD Grant (SFRH/BD/43399/2008) and J.A.F. has a Postdoctoral Grant (SFRH/BPD/66288/2009) from ...

    Article • Urologic Oncology Seminars and Original Investigations, May 2014, Elsevier

    Professor Luis Lima

  36. FASL polymorphism is associated with response to bacillus Calmette-Guérin immunotherapy in bladder cancer

    Article • Urologic Oncology Seminars and Original Investigations, January 2014, Elsevier

    Professor Luis Lima, Paula Videira

  37. Common Genetic Polymorphisms in the ABCB1 Gene Are Associated with Risk of Major Depressive Disorder in Male Portuguese Individuals

    Article • Genetic Testing and Molecular Biomarkers, January 2014, Mary Ann Liebert Inc

    Professor Luis Lima

  38. Response of high-risk of recurrence/progression bladder tumours expressing sialyl-Tn and sialyl-6-T to BCG immunotherapy

    Article • British Journal of Cancer, September 2013, Springer Science + Business Media

    Professor Luis Lima, Paula Videira

  39. Frequency of TERT promoter mutations in human cancers

    Article • Nature Communications, July 2013, Springer Science + Business Media

    Professor Luis Lima, Valdemar Máximo, Paula Soares, MD, PhD,IFCAP José Manuel Lopes

  40. Overexpression of tumour-ssociated carbohydrate antigen sialyl-Tn in advanced bladder tumours

    Article • Molecular Oncology, March 2013, Wiley

    Professor Luis Lima, Paula Videira

  41. Predictive Biomarkers of Bacillus Calmette-Guérin Immunotherapy Response in Bladder Cancer: Where Are We Now?

    Article • Advances in Urology, January 2012, Hindawi Publishing Corporation

    Professor Luis Lima

  42. CIS is a surrogate marker of genetic instability and field carcinogenesis in the urothelial mucosa

    Article • Urologic Oncology Seminars and Original Investigations, March 2011, Elsevier

    Professor Luis Lima

  43. IL-4 and TNF-α Polymorphisms Are Associated with Risk of Multiple Superficial Tumors or Carcinoma in situ Development

    Article • Urologia Internationalis, January 2011, Karger Publishers

    Professor Luis Lima, Paula Videira

  44. Association between FAS polymorphism and prostate cancer development

    Article • Prostate Cancer and Prostatic Diseases, July 2007, Springer Science + Business Media

    Professor Luis Lima