All Stories

  1. Blockage of the peri-synaptic Schwann cell nicotinic α7 receptor inhibitory drive increases the neuromuscular performance in rats with experimental autoimmune Myasthenia gravis: repurposing dipyridamole usage in myasthenics
  2. Bisphenol A and Its Analogue Bisphenol S Inhibit Cholinergic Neurotransmission at the Tripartite Colonic Myenteric Synapse of CD1 Mice by Targeting Interstitial Cells of Cajal
  3. Physical Exercise Alleviates Oxidative Stress and Autonomic Dysregulation in a Rat Model of Inflammatory Bowel Disease
  4. Endomyocardial fibrosis: recent advances and future therapeutic targets
  5. Anti-Hyperalgesic Effect of Isopulegol Involves GABA and NMDA Receptors in a Paclitaxel-Induced Neuropathic Pain Model
  6. Differential participation of CaMKII/ROCK and NOS pathways in the cholinergic inhibitory drive operated by nicotinic α7 receptors in perisynaptic Schwann cells
  7. Mechanical stimulation-induced purinome priming fosters osteogenic differentiation and osteointegration of mesenchymal stem cells from the bone marrow of post-menopausal women
  8. Molecular pathways underlying sympathetic autonomic overshooting leading to fear and traumatic memories: looking for alternative therapeutic options for post-traumatic stress disorder
  9. 2,4,5-Triaminopyrimidines as blue fluorescent probes for cell viability monitoring: synthesis, photophysical properties, and microscopy applications
  10. Adenosinergic System and BDNF Signaling Changes as a Cross-Sectional Feature of RTT: Characterization of Mecp2 Heterozygous Mouse Females
  11. The Carcinogenic Potential of Bisphenol A in the Liver Based on Transcriptomic Studies
  12. Could hypoxia rehabilitate the osteochondral diseased interface? Lessons from the interplay of hypoxia and purinergic signals elsewhere
  13. Editorial: Cellular and molecular targets in epileptogenesis focusing on disease prevention
  14. Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension
  15. Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors
  16. Purinergic Tuning of the Tripartite Neuromuscular Synapse
  17. RNA-seq reveals that anti-obesity irisin and triiodothyronine (T3) hormones differentially affect the purinergic signaling transcriptomics in differentiated human adipocytes
  18. Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator
  19. P2X7 receptor antagonist improves gastrointestinal disorders in spontaneously hypertensive rats
  20. A2A receptor-induced overexpression of pannexin-1 channels indirectly mediates adenosine fibrogenic actions by favouring ATP release from human subcutaneous fibroblasts
  21. Mesial Temporal Lobe Epilepsy (MTLE) Drug-Refractoriness Is Associated With P2X7 Receptors Overexpression in the Human Hippocampus and Temporal Neocortex and May Be Predicted by Low Circulating Levels of miR-22
  22. REDUCTION OF HEART RATE VIA P2X4 RECEPTOR ACTIVATION AS A PROMISING TREATMENT STRATEGY IN PULMONARY ARTERIAL HYPERTENSION
  23. Pharmacological Tuning of Adenosine Signal Nuances Underlying Heart Failure With Preserved Ejection Fraction
  24. A2A Receptor-induced Overexpression of Pannexin-1 Hemichannels Indirectly Mediates Adenosine Fibrogenic Actions in Subcutaneous Human Fibroblasts by Favoring ATP Release
  25. VIPergic neuroprotection in epileptogenesis: challenges and opportunities
  26. Pitfalls and challenges of the purinergic signaling cascade in obesity
  27. Increased choroidal thickness is not a disease progression marker in keratoconus
  28. Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling
  29. Non-genomic Actions of Methylprednisolone Differentially Influence GABA and Glutamate Release From Isolated Nerve Terminals of the Rat Hippocampus
  30. Resolving the Ionotropic P2X4 Receptor Mystery Points towards a New Therapeutic Target for Cardiovascular Diseases
  31. Adenosinergic signalling in chondrogenesis and cartilage homeostasis: Friend or foe?
  32. Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers
  33. Nicotinic α7 receptor‐induced adenosine release from perisynaptic Schwann cells controls acetylcholine spillover from motor endplates
  34. β 3 Adrenoceptor‐induced cholinergic inhibition in human and rat urinary bladders involves the exchange protein directly activated by cyclic AMP 1 favoring adenosine release
  35. Endomyocardial Fibrosis: an Update After 70 Years
  36. Activation of Prejunctional P2x2/3 Heterotrimers by ATP Enhances the Cholinergic Tone in Obstructed Human Urinary Bladders
  37. ß3-adrenoceptor inhibition of cholinergic bladder nerves requires retrograde adenosine release triggered by EPAC/PKC/ENT1 pathway in the human and rat detrusor
  38. The Ionotropic P2X4 Receptor has Unique Properties in the Heart by Mediating the Negative Chronotropic Effect of ATP While Increasing the Ventricular Inotropy
  39. Tetanic Facilitation of Neuromuscular Transmission by Adenosine A2A and Muscarinic M1 Receptors is Dependent on the Uptake of Choline via High-Affinity Transporters
  40. Regulation of corneal noradrenaline release and topography of sympathetic innervation: Functional implications for adrenergic mechanisms in the human cornea
  41. Is the adenosine A 2B ‘biased’ receptor a valuable target for the treatment of pulmonary arterial hypertension?
  42. Under stressful conditions activation of the ionotropic P2X7 receptor differentially regulates GABA and glutamate release from nerve terminals of the rat cerebral cortex
  43. Post-inflammatory Ileitis Induces Non-neuronal Purinergic Signaling Adjustments of Cholinergic Neurotransmission in the Myenteric Plexus
  44. Neuromuscular paralysis by the basic phospholipase A 2 subunit of crotoxin from Crotalus durissus terrificus snake venom needs its acid chaperone to concurrently inhibit acetylcholine release and produce muscle blockage
  45. Inverse correlation between miR-22 serum levels and p2x7r-mediated inflammatory response in mesial temporal lobe epilepsy patients
  46. Methylprednisolone as a memory enhancer in rats: Effects on aversive memory, long-term potentiation and calcium influx
  47. Inhibition of cholinergic neurotransmission by β3-adrenoceptors depends on adenosine release and A1 receptors activation in human and rat urinary bladders
  48. The Use of Laser Microdissection in Forensic Sexual Assault Casework: Pros and Cons Compared to Standard Methods
  49. Assessment of DNA and mtDNA Degradation in Sperm Cells Collected by Laser Micro-dissection
  50. ADP-Induced Ca2+ Signaling and Proliferation of Rat Ventricular Myofibroblasts Depend on Phospholipase C-Linked TRP Channels Activation Within Lipid Rafts
  51. Adenosine A2A receptor and ecto-5′-nucleotidase/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE)
  52. Increased Urinary Adenosine Triphosphate in Patients With Bladder Outlet Obstruction Due to Benign Prostate Hyperplasia
  53. Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria
  54. Mesenchymal Stem Cells Ageing: Targeting the “Purinome” to Promote Osteogenic Differentiation and Bone Repair
  55. Up-regulation of P2X7 receptor-mediated inhibition of GABA uptake by nerve terminals of the human epileptic neocortex
  56. Biomarker sensitivity of plasma adenosine levels to predict heart failure in dogs
  57. Adenosine A2A receptor-mediated facilitation of myenteric cholinergic neurotransmission is impaired in the ileum of diabetic rats
  58. Novel anti-fibrotic effect of the UTP-sensitive P2Y11 receptor in rat cardiac myofibroblasts
  59. Blockage of UDP-sensitive P2Y6 receptors as a novel therapeutic strategy to control urine storage symptoms in men with bladder outlet obstruction
  60. Neuronal to non-neuronal shift of purine resources in the tripartite myenteric synapse of postinflammatory ileitis
  61. Calcium signaling and the novel anti-proliferative effect of the UTP-sensitive P2Y11 receptor in rat cardiac myofibroblasts
  62. Impairment of ATP hydrolysis decreases adenosine A1 receptor tonus favoring cholinergic nerve hyperactivity in the obstructed human urinary bladder
  63. P2X7 receptor activation downmodulates Na+-dependent high-affinity GABA and glutamate transport into rat brain cortex synaptosomes
  64. Activation of P2Y6 Receptors Facilitates Nonneuronal Adenosine Triphosphate and Acetylcholine Release from Urothelium with the Lamina Propria of Men with Bladder Outlet Obstruction
  65. Involvement of mitochondrial proteins in calcium signaling and cell death induced by staurosporine in Neurospora crassa
  66. Inverse gradient of nitrergic and purinergic inhibitory cotransmission in the mouse colon
  67. Impact of ectonucleotidases in autonomic nervous functions
  68. The Effect of Ischemia and Reperfusion on Enteric Glial Cells and Contractile Activity in the Ileum
  69. Amplification of neuromuscular transmission by methylprednisolone involves activation of presynaptic facilitatory adenosine A2A receptors and redistribution of synaptic vesicles
  70. Deficits in Endogenous Adenosine Formation by Ecto-5′-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis
  71. Abstracts from Purines 2014, an International Conference on Nucleotides, Nucleosides and Nucleobases, held in Bonn, Germany, from July 23–27, 2014
  72. Extracellular calcium triggers unique transcriptional programs and modulates staurosporine-induced cell death in Neurospora crassa
  73. P2X7-induced zeiosis promotes osteogenic differentiation and mineralization of postmenopausal bone marrow-derived mesenchymal stem cells
  74. Lack of Endogenous Adenosine Tonus on Sympathetic Neurotransmission in Spontaneously Hypertensive Rat Mesenteric Artery
  75. Attenuated Aortic Vasodilation and Sympathetic Prejunctional Facilitation in Epinephrine-Deficient Mice: Selective Impairment of β2-Adrenoceptor Responses
  76. Activation of a TRP-like channel and intracellular Ca2+ dynamics during phospholipase-C-mediated cell death
  77. P109Opposite actions of atrial adenosine A1 receptor on G protein-coupled inwardly-rectifying potassium (GIRK/Kir3.1/3.4) and small Ca2+-activated K+ outward (KCa2/SK) currents
  78. P609Activation of the P2X4 receptor selectively reduces heart rate with preservation of the ventricular function by reversing of Na+/Ca2+ exchanger (NCX) mode in the rat
  79. Activation of P2Y6receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium
  80. Age-related Pharmacology
  81. Paradoxical neostigmine-induced TOFfade: On the role of presynaptic cholinergic and adenosine receptors
  82. ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors
  83. Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis
  84. Dual role of P2Y6 receptors in the human urinary bladder: On the role of ATP released from the urothelium
  85. Changes in the fine-tuning adenosine control of acetylcholine release from myenteric motoneurons in TNBS-inflamed rat ileum
  86. Expression of adenosine kinase in human mesial temporal lobe epilepsy with hippocampal sclerosis: A preliminary study
  87. Histamine Induces ATP Release from Human Subcutaneous Fibroblasts, via Pannexin-1 Hemichannels, Leading to Ca 2+ Mobilization and Cell Proliferation
  88. Overactive bladder syndrome: Evidence that urinary ATP is a dynamic biomarker of detrusor overactivity
  89. Urinary ATP May Be a Dynamic Biomarker of Detrusor Overactivity in Women with Overactive Bladder Syndrome
  90. Doxorubicin decreases paraquat accumulation and toxicity in Caco-2 cells
  91. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation
  92. Bothropstoxin-I reduces evoked acetylcholine release from rat motor nerve terminals: Radiochemical and real-time video-microscopy studies
  93. Adenosine A2Areceptor antagonists are broad facilitators of antinicotinic neuromuscular blockade monitored either with 2 Hz train-of-four or 50 Hz tetanic stimuli
  94. Synthesis of new chiral xanthone derivatives acting as nerve conduction blockers in the rat sciatic nerve
  95. Adenosine A2Areceptor antagonists are broad facilitators of antinicotinic neuromuscular blockade monitored either with 2-Hz train-of-four or 50-Hz tetanic stimuli
  96. Bradykinin activation of fibroblasts of the rat subcutaneous tissue triggers the release of ATP and P2 purinoceptors activation
  97. Role of ecto‐NTPDases on UDP‐sensitive P2Y6receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women
  98. Localization and function of adenosine receptor subtypes at the longitudinal muscle – Myenteric plexus of the rat ileum
  99. Presynaptic muscarinic and adenosine receptors are involved in 2 Hz-induced train-of-four fade caused by antinicotinic neuromuscular relaxants in the rat
  100. Bladder overactivity due to global impairment of ecto-NTPDases in humans with lower urinary tract disorders exhibiting unbalanced ATP/adenosine formation
  101. Amplification of cholinergic neurotransmission by adenosine released from Interstitial Cells of Cajal at a tripartite myenteric synapse of the rat ileum
  102. Tetanic failure due to decreased endogenous adenosine A2A tonus operating neuronal Cav1 (L-type) influx in Myasthenia gravis
  103. Presynaptic facilitatory adenosine A2A receptors mediate fade induced by neuromuscular relaxants that exhibit anticholinesterase activity
  104. On the role of subtype selective adenosine receptor agonists during proliferation and osteogenic differentiation of human primary bone marrow stromal cells
  105. Free Communications in Focused Conferences
  106. Purines 2010: Adenine Nucleosides and Nucleotides in Biomedicine
  107. Determinantes clínicos com influência no prognóstico da discectomia lombar: análise multifatorial
  108. Apamin reduces neuromuscular transmission by activating inhibitory muscarinic M2 receptors on motor nerve terminals
  109. Functional Transient Receptor Potential Vanilloid 1 is Expressed in Human Urothelial Cells
  110. Muscarinic M3facilitation of acetylcholine release from rat myenteric neurons depends on adenosine outflow leading to activation of excitatory A2Areceptors
  111. Osteoblastic Behavior of Human Bone Marrow Cells Cultured Over Adsorbed Collagen Layer, Over Surface of Collagen Gels, and Inside Collagen Gels
  112. Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate
  113. S5.7 Sustained P2X3 facilitation of acetylcholine release contributes to bladder hyperactivity in humans with benign prostatic hyperplasia
  114. P4.20 On the role of adenosine (A2A) tonus and cross talk with NK1 and M3 receptors regulating acetylcholine release from myenteric neurons of the rat ileum
  115. 276 ACTIVATION OF P2×1 PURINOCEPTORS FACILITATE EVOKED ACETYLCHOLINE RELEASE IN HUMAN OBSTRUCTED BLADDERS
  116. Relative contribution of ecto-ATPase and ecto-ATPDase pathways to the biphasic effect of ATP on acetylcholine release from myenteric motoneurons
  117. ATP released from the urothelium contributes to bladder hyperactivity induced by acetic acid in the rat
  118. Neonatal Capsaicin-treated rats have reduced extracellular purine levels in the Myenteric Plexus
  119. On the mechanism by which newly synthesized xanthone derivatives cause conduction blockade of the rat sciatic nerve
  120. Cross talk between facilitatory adenosine A2A, Tachykinin NK1 and Muscarinic M3 receptors in the rat Mynteric plexus: on the role of Capsaicin-sensitive Tachykinergic neurons
  121. Impairment of the adaptive shift from CAv2.1 (p/q type) to CAv1 (L-type) channels contributes to tetanic failure in myasthenia gravis: On the role of adenosine A2A receptors
  122. Adenosine Tonus is Impaired in Toxin Induced Myasthenia Gravis
  123. Physical, chemical and in vitro biological profile of chitosan hybrid membrane as a function of organosiloxane concentration☆
  124. Decreased Ecto-Ntpdase1/Cd39 Activity Leads to Desensitization of P2 Purinoceptors Regulating Tonus of Corpora Cavernosa in Impotent Men with Endothelial Dysfunction
  125. Tuning adenosine A1 and A2A receptors activation mediates l-citrulline-induced inhibition of [3H]-acetylcholine release depending on nerve stimulation pattern
  126. Muscarinic M3 facilitation of acetylcholine release from rat myenteric neurons depends on A2A receptors activation
  127. Hyperactivity of cholinergic nerves associated with decreased hydrolysis of ATP in obstructed human bladders
  128. L -Citrulline inhibits [3 H]acetylcholine release from rat motor nerve terminals by increasing adenosine outflow and activation of A1 receptors
  129. 786: Decreased ECTO-NTPDASE 1 Activity Reduces Adenosine Formation from the Hydrolysis of Adenine Nucleotides in the Corpus Cavernosum from Impotent Men
  130. 249: Decreased Hydrolysis of ATP Acting Via P2X Receptors Favour Cholinergic Nerve Hyperactivity in Human Obstructed Bladders
  131. In vitro models of periodontal cells: a comparative study of long-term gingival, periodontal ligament and alveolar bone cell cultures in the presence of β-glycerophosphate and dexamethasone
  132. Paradoxical nifedipine facilitation of 45Ca uptake into rat hippocampal synaptosomes
  133. Corpus Cavernosum from Men with Vasculogenic Impotence Is Partially Resistant to Adenosine Relaxation due to Endothelial A2B Receptor Dysfunction
  134. Fine-tuning modulation of myenteric motoneurons by endogenous adenosine: On the role of secreted adenosine deaminase
  135. Dissociation between M1-facilitation of acetylcholine release and crosstalk with A2A- and M2-receptors on rat motoneurons
  136. Protein Kinase A and Cav1 (L-Type) Channels Are Common Targets to Facilitatory Adenosine A2A and Muscarinic M1 Receptors on Rat Motoneurons
  137. Tetanic depression is overcome by tonic adenosine A2Areceptor facilitation of L-type Ca2+influx into rat motor nerve terminals
  138. Adenosine activating A2A-receptors coupled to adenylate cyclase/cyclic AMP pathway downregulates nicotinic autoreceptor function at the rat myenteric nerve terminals
  139. Fine-tuning modulation of neuronal muscarinic M1 (facilitatory) and M2 (inhibitory) receptor activation by adenosine at the rat neuromuscular junction
  140. Dual effects of adenosine on acetylcholine release from myenteric motoneurons are mediated by junctional facilitatory A2A and extrajunctional inhibitory A1 receptors
  141. Biological Activity of Two Glass Ceramics in the Meta- and Pyrophosphate Region: a Comparative Study
  142. In Vitro Mineralisation of Human Bone Marrow Cells Cultured on Bonelike®
  143. Ecto‐AMP Deaminase Blunts the ATP‐Derived Adenosine A2A Receptor Facilitation of Acetylcholine Release at Rat Motor Nerve Endings
  144. Blockade of neuronal facilitatory nicotinic receptors containing α3β2 subunits contribute to tetanic fade in the rat isolated diaphragm
  145. Endogenous adenosine prevents post-tetanic release facilitation mediated by α3β2 nicotinic autoreceptors
  146. Si3N4-bioglass composites stimulate the proliferation of MG63 osteoblast-like cells and support the osteogenic differentiation of human bone marrow cells
  147. Modulation by adenosine of both muscarinic M1-facilitation and M2-inhibition of [3H]-acetylcholine release from the rat motor nerve terminals
  148. A2A Adenosine Receptor Facilitation of Neuromuscular Transmission
  149. Synergism between A2A-adenosine receptor activation and vasoactive intestinal peptide to facilitate [3H]-acetylcholine release from the rat motor nerve terminals
  150. Adenosine receptor interactions in the hippocampus
  151. Influence of stimulation on Ca2+ recruitment triggering [3H]acetylcholine release from the rat motor-nerve endings
  152. Long-term effects of parathyroid hormone, 1,25-dihydroxyvitamin d3, and dexamethasone on the cell growth and functional activity of human osteogenic alveolar bone cell cultures
  153. 24 Neuropeptidergic facilitation of acetylcholine release from motor nerve terminals depends on tonic A2A-adenosine receptor activation
  154. Purinoceptors and synaptic plasticity
  155. Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides
  156. Adenosine uptake and deamination regulate tonic A2a receptor facilitation of evoked [3H]acetylcholine release from the rat motor nerve terminals
  157. Chapter 23 Purinergic regulation of acetylcholine release
  158. Role of A2a Receptors in the Hippocampus and Motor Nerve Endings
  159. Tonic adenosine A2A receptor activation modulates nicotinic autoreceptor function at the rat neuromuscular junction
  160. Evidence that the presynaptic A2a-adenosine receptor of the rat motor nerve endings is positively coupled to adenylate cyclase
  161. Potentiation by tonic A2a-adenosine receptor activation of CGRP-facilitated [3H]-ACh release from rat motor nerve endings
  162. Facilitation of [3H]-ACh release by forskolin depends on A2-adenosine receptor activation
  163. The excitatory effect of forskalin on 3H-acetylcholine release from rat motor nerve endings depends on the presence of adenosine
  164. Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve endings of the rat