All Stories

  1. Fluorimetric Detection of Insulin Misfolding by Probes Derived from Functionalized Fluorene Frameworks
  2. Structure-Antitumor Activity Relationships of Aza- and Diaza-Anthracene-2,9,10-Triones and Their Partially Saturated Derivatives
  3. Cyclodextrin Inclusion Complexes for Improved Drug Bioavailability and Activity: Synthetic and Analytical Aspects
  4. Rapid Assembly of Functionalized 2H-Chromenes and 1,2-Dihydroquinolines via Microwave-Assisted Secondary Amine-Catalyzed Cascade Annulation of 2-O/N-Propargylarylaldehydes with 2,6-Dialkylphenols
  5. Quinones as Neuroprotective Agents
  6. m-Terphenylamines, Acting as Selective COX-1 Inhibitors, Block Microglia Inflammatory Response and Exert Neuroprotective Activity
  7. Small-molecule theranostics in Alzheimer's disease
  8. A New Method for the Introduction of an Acylsulfonamide Moiety Applied to a 3-Substituted Functionalized Indole Framework ­Related to the Welwitindolinone Alkaloids
  9. 2-(3-Bromophenyl)imidazo[2,1-b]oxazole
  10. Anticancer drugs acting on signaling pathways, part 1: Tyrosine kinase inhibitors
  11. Anticancer drugs acting on signaling pathways, part 2: Inhibitors of serine-threonine kinases and miscellaneous signaling pathways
  12. Anticancer drugs targeting tubulin and microtubules
  13. Anticancer drugs that interact with the DNA minor groove
  14. Anticancer drugs that modulate hormone action
  15. Anticancer strategies involving radical species
  16. Antimetabolites
  17. Cancer chemoprevention
  18. Cancer immunotherapy
  19. DNA alkylating agents
  20. DNA intercalation and topoisomerase inhibition
  21. Drug targeting in anticancer chemotherapy
  22. Drugs that modulate resistance to antitumor agents
  23. Epigenetic therapy of cancer
  24. General aspects of cancer therapy
  25. Miscellaneous small- molecule and biological approaches to targeted cancer therapy
  26. Protein degradation-based cancer therapy
  27. Small Molecules as Toll-like Receptor 4 Modulators Drug and In-House Computational Repurposing
  28. An Efficient Synthesis of a Highly Functionalized Dihydrobenzo­thiophene Derivative: A Ring-Contracted Analogue of the Anti-inflammatory Drug Propoxicam
  29. Fluorescence Sensors Based on Hydroxycarbazole for the Determination of Neurodegeneration-Related Halide Anions
  30. Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry Perspective
  31. Enantioselective Synthesis and Pharmacological Evaluation of Aza-CGP37157–Lipoic Acid Hybrids for the Treatment of Alzheimer’s Disease
  32. Enantioselective catalytic Povarov reactions
  33. Curcumin-Piperlongumine Hybrids with a Multitarget Profile Elicit Neuroprotection in In Vitro Models of Oxidative Stress and Hyperphosphorylation
  34. Enhanced Stability and Bioactivity of Natural Anticancer Topoisomerase I Inhibitors through Cyclodextrin Complexation
  35. Mechanochemical Synthesis of Primary Amides
  36. Neuroprotective Action of Multitarget 7-Aminophenanthridin-6(5H)-one Derivatives against Metal-Induced Cell Death and Oxidative Stress in SN56 Cells
  37. Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation
  38. (2S*,4S*)-4-[(E)-(2,2-Dimethylhydrazono)methyl]-6-methoxy-4-methyl-2-[(E)-styryl]-1,2,3,4-tetrahydroquinoline
  39. (E)-3-((2-Fluorophenyl)(hydroxy)methylene)imidazo[1,2-a]pyridin-2(3H)-one
  40. Mechanochemical Aza-Vinylogous Povarov Reactions for the Synthesis of Highly Functionalized 1,2,3,4-Tetrahydroquinolines and 1,2,3,4-Tetrahydro-1,5-Naphthyridines
  41. Sustainable Access to Acridin-9-(10H)ones with an Embedded m-Terphenyl Moiety Based on a Three-Component Reaction
  42. Synthesis of 1,4-Diazepanes and Benzo[b][1,4]diazepines by a Domino Process Involving the In Situ Generation of an Aza-Nazarov Reagent
  43. Antioxidant, Anti-inflammatory and Neuroprotective Profiles of Novel 1,4-Dihydropyridine Derivatives for the Treatment of Alzheimer’s Disease
  44. Antioxidants as Molecular Probes: Structurally Novel Dihydro-m-Terphenyls as Turn-On Fluorescence Chemodosimeters for Biologically Relevant Oxidants
  45. NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
  46. D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity
  47. Front Cover: Rearrangement Reactions in Aza-Vinylogous Povarov Products: Metal-Free Synthesis of C3 -Functionalized Quinolines and Studies on their Synthetic Application (Eur. J. Org. Chem. 38/2019)
  48. Proline and its Derivatives as Organocatalysts for Multi‐ Component Reactions in Aqueous Media: Synergic Pathways to the Green Synthesis of Heterocycles
  49. Rearrangement Reactions in Aza-Vinylogous Povarov Products: Metal-Free Synthesis of C3 -Functionalized Quinolines and Studies on their Synthetic Application
  50. Design and synthesis of A- and D ring-modified analogues of luotonin A with reduced planarity
  51. Spirooxindole-pyrrolidine heterocyclic hybrids promotes apoptosis through activation of caspase-3
  52. Structure-activity relationships and mechanistic studies of novel mitochondria-targeted, leishmanicidal derivatives of the 4-aminostyrylquinoline scaffold
  53. Progress in the Chemistry of Tetrahydroquinolines
  54. Diversity‐Oriented Synthesis of Complex Pyrrole‐Based Architectures from Very Simple Starting Materials
  55. Multicomponent domino protocol for the stereoselective synthesis of novel pyrrolo[3,2-c]quinolinone hybrid heterocycles
  56. Heterogeneous Amberlyst-15-catalyzed synthesis of complex hybrid heterocycles containing [1,6]-naphthyridine under metal-free green conditions
  57. Oxidant-free, three-component synthesis of 7-amino-6H-benzo[c]chromen-6-ones under green conditions
  58. The Hantzsch Pyrrole Synthesis: Non-conventional Variations and Applications of a Neglected Classical Reaction
  59. Three-Component Synthesis of a Library of m-Terphenyl Derivatives with Embedded β-Aminoester Moieties
  60. Multicomponent Domino Synthesis, Anticancer Activity and Molecular Modeling Simulation of Complex Dispirooxindolopyrrolidines
  61. Highly functionalized pyrrolidine analogues: stereoselective synthesis and caspase-dependent apoptotic activity
  62. Multicomponent mechanochemical synthesis
  63. A systematic 1 H- and 13 C-NMR spectral analysis of bicyclo[n.3.1]alkanone systems: Determination of the relative configuration of the stereogenic centres and conformation of the six-membered ring
  64. One-Pot Synthesis of Functionalized Carbazoles via a CAN-Catalyzed Multicomponent Process Comprising a C–H Activation Step
  65. Mild and General Synthesis of Pyrrolo[2,1-a]isoquinolines and Related Polyheterocyclic Frameworks from Pyrrole Precursors Derived from a Mechanochemical Multicomponent Reaction
  66. Synthesis of 6,12-Epiminodibenzo[b,f][1,5]diazocines via an Ytterbium Triflate-Catalyzed, AB2 Three-Component Reaction
  67. Three-component synthesis of highly functionalized aziridines containing a peptide side chain and their one-step transformation into β-functionalized α-ketoamides
  68. From Simple Cyclic 1,3-Ketoamides to Complex Spirolactams by Supported Heterogeneous Organocatalysis with PS-BEMP
  69. Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents
  70. One-Pot Access to a Library of Dispiro Oxindole-pyrrolidine/pyrrolothiazole-thiochromane Hybrids via Three-Component 1,3-Dipolar Cycloaddition Reactions
  71. Three-Component Synthesis of Pyrrole-Related Nitrogen Heterocycles by a Hantzsch-Type Process: Comparison between Conventional and High-Speed Vibration Milling Conditions
  72. A Sustainable Approach to the Stereoselective Synthesis of Diazaheptacyclic Cage Systems Based on a Multicomponent Strategy in an Ionic Liquid
  73. ChemInform Abstract: Dipolar Cycloaddition-Based Multicomponent Reactions in Ionic Liquids: A Green, Fully Stereoselective Synthesis of Novel Polycyclic Cage Systems with the Generation of Two New Azaheterocyclic Rings.
  74. ChemInform Abstract: Expedient, Catalyst-Free, Three-Component Synthesis of Fused Tetrahydropyridines in Water.
  75. Efficient synthesis of 2-acylquinolines based on an aza-vinylogous Povarov reaction
  76. Three-component access to 2-pyrrolin-5-ones and their use in target-oriented and diversity-oriented synthesis
  77. Synthesis of 5,6-Dihydrodibenzo[b,h][1,6]naphthyridines via Copper Bromide Catalyzed Intramolecular [4 + 2] Hetero-Diels–Alder Reactions
  78. Straightforward synthesis of pyrrolo[3,4-b]quinolines through intramolecular Povarov reactions
  79. ChemInform Abstract: An Efficient Synthesis of N-Substituted 3-Nitrothiophen-2-amines.
  80. ChemInform Abstract: Highly Efficient Regioselective Synthesis of Pyrroles via a Tandem Enamine Formation-Michael Addition-Cyclization Sequence under Catalyst- and Solvent-Free Conditions.
  81. An efficient synthesis of N-substituted 3-nitrothiophen-2-amines
  82. An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction
  83. ChemInform Abstract: Palladium(II)-Catalyzed Intramolecular Carboxypalladation-Olefin Insertion Cascade: Direct Access to Indeno[1,2-b]furan-2-ones.
  84. Dipolar Cycloaddition-Based Multicomponent Reactions in Ionic Liquids: A Green, Fully Stereoselective Synthesis of Novel Polycyclic Cage Systems with the Generation of Two New Azaheterocyclic Rings
  85. ChemInform Abstract: Lewis Acid-Catalyzed Generation of C-C and C-N Bonds on π-Deficient Heterocyclic Substrates.
  86. Six-Membered Heterocycles
  87. ChemInform Abstract: One-Pot α-Amidosulfone-Mediated Variation of the Pictet-Spengler Tetrahydroisoquinoline Synthesis, Suitable for Amide-Type Substrates.
  88. ChemInform Abstract: A Heavy Metal- and Oxidant-Free, One-Pot Synthesis of Pyridines and Fused Pyridines Based on a Lewis Acid-Catalyzed Multicomponent Reaction.
  89. Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience
  90. Palladium(ii)-catalyzed intramolecular carboxypalladation–olefin insertion cascade: direct access to indeno[1,2-b]furan-2-ones
  91. Highly efficient regioselective synthesis of pyrroles via a tandem enamine formation–Michael addition–cyclization sequence under catalyst- and solvent-free conditions
  92. Cancer Chemoprevention
  93. Preface
  94. DNA Alkylating Agents
  95. Biological Therapy of Cancer
  96. Anticancer Drugs Targeting Tubulin and Microtubules
  97. Drug Targeting in Anticancer Chemotherapy
  98. Anticancer Drugs Acting via Radical Species
  99. Anticancer Drugs That Modulate Hormone Action
  100. Epigenetic Therapy of Cancer
  101. General Aspects of Cancer Chemotherapy
  102. Drugs That Modulate Resistance to Antitumor Agents
  103. Antimetabolites That Interfere with Nucleic Acid Biosynthesis
  104. Other Nonbiological Approaches to Targeted Cancer Chemotherapy
  105. Anticancer Drugs That Interact with the DNA Minor Groove
  106. Other Anticancer Drugs Targeting DNA and DNA-Associated Enzymes
  107. Drugs That Inhibit Signaling Pathways for Tumor Cell Growth and Proliferation
  108. ChemInform Abstract: Fully Diastereoselective Synthesis of Polysubstituted, Functionalized Piperidines and Decahydroquinolines Based on Multicomponent Reactions Catalyzed by Cerium(IV) Ammonium Nitrate.
  109. Expedient, catalyst-free, three-component synthesis of fused tetrahydropyridines in water
  110. Lewis Acid-Catalyzed Generation of CC and CN Bonds on π-Deficient Heterocyclic Substrates
  111. Axial Chirality of 4-Arylpyrazolo[3,4-b]pyridines. Conformational Analysis and Absolute Configuration
  112. ChemInform Abstract: Recent Advances in the Synthesis of Pyrroles by Multicomponent Reactions
  113. One-Pot α-Amidosulfone-Mediated Variation of the Pictet-Spengler Tetrahydroisoquinoline Synthesis, Suitable for Amide-Type Substrates
  114. Fully Diastereoselective Synthesis of Polysubstituted, Functionalized Piperidines and Decahydroquinolines Based on Multicomponent Reactions Catalyzed by Cerium(IV) Ammonium Nitrate
  115. Montmorillonite Clay-Promoted, Solvent-Free Cross-Aldol Condensations under Focused Microwave Irradiation
  116. B-Ring-Aryl Substituted Luotonin A Analogues with a New Binding Mode to the Topoisomerase 1-DNA Complex Show Enhanced Cytotoxic Activity
  117. New 5-Unsubstituted Dihydropyridines with Improved CaV1.3 Selectivity as Potential Neuroprotective Agents against Ischemic Injury
  118. A catalyst-free multicomponent domino sequence for the diastereoselective synthesis of (E)-3-[2-arylcarbonyl-3-(arylamino)allyl]chromen-4-ones
  119. ChemInform Abstract: A β-Enaminone-Initiated Multicomponent Domino Reaction for the Synthesis of Indoloquinolizines and Benzoquinolizines from Acyclic Precursors.
  120. Concise synthesis of atorvastatin lactone under high-speed vibration milling conditions
  121. Recent advances in the synthesis of pyrroles by multicomponent reactions
  122. A heavy metal- and oxidant-free, one-pot synthesis of pyridines and fused pyridines based on a Lewis acid-catalyzed multicomponent reaction
  123. Synthesis of Heterocycles Through Multicomponent Reactions in Water
  124. ChemInform Abstract: A New CAN-Catalyzed Domino Process Related to the Nenitzescu Reaction: Very Concise Access to Fused ortho-Indolequinones from Simple Precursors.
  125. Modulation of Prion by Small Molecules: From Monovalent to Bivalent and Multivalent Ligands
  126. ChemInform Abstract: Chemodivergent, Multicomponent Domino Reactions in Aqueous Media: L-Proline-Catalyzed Assembly of Densely Functionalized 4H-Pyrano[2,3-c]pyrazoles and Bispyrazolyl Propanoates from Simple, Acyclic Starting Materials.
  127. ChemInform Abstract: Michael Additions in Aqueous Media: “On-Water” and “In-Water” Processes from α-Nitro Ketones and Their Anions.
  128. A β-Enaminone-Initiated Multicomponent Domino Reaction for the Synthesis of Indoloquinolizines and Benzoquinolizines from Acyclic Precursors
  129. A new CAN-catalyzed domino process related to the Nenitzescu reaction: very concise access to fused ortho-indolequinones from simple precursors
  130. Editorial (Hot Topic: Multibond Forming Reactions: A New Frontier in the Synthesis of Heterocycles)
  131. L-Proline Catalysed Domino Reactions for the Synthesis of Heterocycles
  132. ChemInform Abstract: Diastereoselective, Multicomponent Access to trans-2-Aryl-4-arylamino-1,2,3,4-tetrahydroquinolines via an AA′BC Sequential Four-Component Reaction and Their Application to 2-Arylquinoline Synthesis.
  133. ChemInform Abstract: Microwave-Assisted, Sequential Four-Component Synthesis of Polysubstituted 5,6-Dihydroquinazolinones (IV) from Acyclic Precursors and a Mild, Halogenation-Initiated Method for Their Aromatization [→(V)] under Focused Microwave Irradia
  134. ChemInform Abstract: Three-Component Access to Pyrroles Promoted by the CAN-Silver Nitrate System under High-Speed Vibration Milling Conditions: A Generalization of the Hantzsch Pyrrole Synthesis.
  135. Synthesis of a D Ring-Functionalized Derivative of the Epiwelwistatin Tetracyclic Core
  136. Michael Additions in Aqueous Media: “On-Water” and “In-Water” Processes from α-Nitro Ketones and Their Anions
  137. ChemInform Abstract: Privileged Scaffolds in Synthesis: 2,5-Piperazinediones as Templates for the Preparation of Structurally Diverse Heterocycles
  138. A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer’s and Prion Diseases
  139. Three-component access to pyrroles promoted by the CAN–silver nitrate system under high-speed vibration milling conditions: a generalization of the Hantzsch pyrrole synthesis
  140. Identification of 4,6-diaryl-1,4-dihydropyridines as a new class of neuroprotective agents
  141. Diastereoselective, multicomponent access to trans-2-aryl-4-arylamino-1,2,3,4-tetrahydroquinolines via an AA′BC sequential four-component reaction and their application to 2-arylquinoline synthesis
  142. Chemodivergent, multicomponent domino reactions in aqueous media: l-proline-catalyzed assembly of densely functionalized 4H-pyrano[2,3-c]pyrazoles and bispyrazolyl propanoates from simple, acyclic starting materials
  143. Microwave-assisted, sequential four-component synthesis of polysubstituted 5,6-dihydroquinazolinones from acyclic precursors and a mild, halogenation-initiated method for their aromatization under focused microwave irradiation
  144. Solvent- and chromatography-free amination of π-deficient nitrogen heterocycles under microwave irradiation. A fast, efficient and green route to 9-aminoacridines, 4-aminoquinolines and 4-aminoquinazolines and its application to the synthesis of the dr...
  145. ChemInform Abstract: Facile Ionic Liquid-Mediated, Three-Component Sequential Reactions for the Green, Regio- and Diastereoselective Synthesis of Furocoumarins.
  146. One-Pot Access to a Library of Structurally Diverse Nicotinamide Derivatives via a Three-Component Formal Aza [3 + 3] Cycloaddition
  147. Fluorescence properties of the anti-tumour alkaloid luotonin A and new synthetic analogues: pH modulation as an approach to their fluorimetric quantitation in biological samples
  148. ChemInform Abstract: Aryl Grignard Reagents in Chemodivergent N- and C-Arylations: Concise Access to Two Families of Tetracyclic Fused Carbazoles from 6-Nitroquinolines.
  149. ChemInform Abstract: Domino Reactions in Water: Diastereoselective Synthesis of Densely Functionalized Indolyldihydrofuran Derivatives.
  150. Facile ionic liquid-mediated, three-component sequential reactions for the green, regio- and diastereoselective synthesis of furocoumarins
  151. ChemInform Abstract: Synthesis of Polysubstituted, Functionalized Quinolines Through a Metal-Free Domino Process Involving a C4-C3Functional Group Rearrangement.
  152. Synthesis of Polysubstituted, Functionalized Quinolines through a Metal-Free Domino Process Involving a C 4 –C 3 Functional Group Rearrangement
  153. Aryl Grignard Reagents in Chemodivergent N- and C-Arylations: Concise Access to Two Families of Tetracyclic Fused Carbazoles from 6-Nitroquinolines
  154. ChemInform Abstract: L-Proline-Catalyzed Sequential Four-Component “On Water” Protocol for the Synthesis of Structurally Complex Heterocyclic ortho-Quinones.
  155. New Types of Reactivity of α,β‐Unsaturated N , N ‐Dimethylhydrazones: Chemodivergent Diastereoselective Synthesis of Functionalized Tetrahydroquinolines and Hexahydropyrrolo[3,2‐ b ...
  156. ChemInform Abstract: A General Protocol for the Solvent- and Catalyst-Free Synthesis of 2-Styrylquinolines under Focused Microwave Irradiation.
  157. ChemInform Abstract: Brief, Efficient and Highly Diastereoselective Synthesis of (.+-.)-Pumiliotoxin C Based on the Generation of an Octahydroquinoline Precursor via a Four-Component Reaction.
  158. ChemInform Abstract: L-Proline-Catalyzed Three-Component Domino Reactions for the Diastereoselective Synthesis of 5,6-Disubstituted 3-Thiomorpholinones.
  159. Privileged scaffolds in synthesis: 2,5-piperazinediones as templates for the preparation of structurally diverse heterocycles
  160. A one-pot sequence for the efficient synthesis of highly functionalized macrocarbocycles or bridged 2,8-dioxabicyclo[3.2.1]octanes from 1-nitrobicyclic compounds
  161. Domino reactions in water: diastereoselective synthesis of densely functionalized indolyldihydrofuran derivatives
  162. A systematic study of two complementary protocols allowing the general, mild and efficient deprotection of N-pivaloylindoles
  163. ChemInform Abstract: Advances in the Chemistry of Tetrahydroquinolines
  164. ChemInform Abstract: A Facile, Three-Component Domino Protocol for the Microwave-Assisted Synthesis of Functionalized Naphtho[2,3-b]furan-4,9-diones in Water.
  165. Advances in the Chemistry of Tetrahydroquinolines
  166. ChemInform Abstract: Domino Reactions for the Synthesis of Bridged Bicyclic Frameworks: Fast Access to Bicyclo[n.3.1]alkanes
  167. A General Protocol for the Solvent- and Catalyst-Free Synthesis of 2-Styrylquinolines under Focused Microwave Irradiation
  168. l-Proline-catalysed three-component domino reactions for the diastereoselective synthesis of 5,6-disubstituted 3-thiomorpholinones
  169. Two chemodivergent anionic domino processes from cyclic α-nitroketones and aromatic aldehydes
  170. ChemInform Abstract: A Facile Three-Component [3 + 2]-Cycloaddition/Annulation Domino Protocol for the Regio- and Diastereoselective Synthesis of Novel Penta- and Hexacyclic Cage Systems, Involving the Generation of Two Heterocyclic Rings and Five Contigu
  171. ChemInform Abstract: Synthesis of Benzo- and Naphtho-Fused Bicyclo[n.3.1]alkane Frameworks with a Bridgehead Nitrogen Function by Palladium-Catalyzed Intramolecular α′-Arylation of α-Nitroketones.
  172. Antimycobacterial activity of novel 1,2,4-oxadiazole-pyranopyridine/chromene hybrids generated by chemoselective 1,3-dipolar cycloadditions of nitrile oxides
  173. ChemInform Abstract: A Three-Component Domino Protocol for the Facile Synthesis of Highly Functionalized Tetrahydroisoquinolines by Creation of Their Benzene Ring.
  174. New four-component reactions in water: a convergent approach to the metal-free synthesis of spiro[indoline/acenaphthylene-3,4′-pyrazolo[3,4-b]pyridine derivatives
  175. A facile three-component [3+2]-cycloaddition/annulation domino protocol for the regio- and diastereoselective synthesis of novel penta- and hexacyclic cage systems, involving the generation of two heterocyclic rings and five contiguous stereocenters
  176. A General, Diastereoselective Synthesis of Highly Functionalized Bicyclo[n.3.1]alkane Systems Based on an Anionic Domino Reaction of α-Nitrocycloalkanones
  177. ChemInform Abstract: CAN-Promoted, Diastereoselective Synthesis of Fused 2,3-Dihydrofurans and Their Transformation into Tetrahydroindoles.
  178. A three-component domino protocol for the facile synthesis of highly functionalized tetrahydroisoquinolines by creation of their benzene ring
  179. ChemInform Abstract: Multicomponent Reactions for the Synthesis of Pyrroles
  180. ChemInform Abstract: Three-Component, Diastereoselective Synthesis of Highly Functionalized Indan Derivatives Based on an Anionic Domino Sequence from α-Nitroketones.
  181. Brief, efficient and highly diastereoselective synthesis of (±)-pumiliotoxin C based on the generation of an octahydroquinoline precursor via a four-component reaction
  182. Domino reactions for the synthesis of bridged bicyclic frameworks: fast access to bicyclo[n.3.1]alkanes
  183. Antimycobacterial activity of spirooxindolo-pyrrolidine, pyrrolizine and pyrrolothiazole hybrids obtained by a three-component regio- and stereoselective 1,3-dipolar cycloaddition
  184. 1,3-Dipolar cycloadditions from tricyclic hemiaminals. Synthesis of the quinocarcin core through catalyst-free generation of azomethine ylides
  185. Synthesis of benzo- and naphtho-fused bicyclo[n.3.1]alkane frameworks with a bridgehead nitrogen function by palladium-catalyzed intramolecular α′-arylation of α-nitroketones
  186. Eco-friendly liquid chromatographic separations based on the use of cyclodextrins as mobile phase additives
  187. l-Proline-catalysed sequential four-component “on water” protocol for the synthesis of structurally complex heterocyclic ortho-quinones
  188. A facile, three-component domino protocol for the microwave-assisted synthesis of functionalized naphtho[2,3-b]furan-4,9-diones in water
  189. CAN-promoted, diastereoselective synthesis of fused 2,3-dihydrofurans and their transformation into tetrahydroindoles
  190. ChemInform Abstract: Expedient, One-Pot Preparation of Fused Indoles via CAN-Catalyzed Three-Component Domino Sequences and Their Transformation into Polyheterocyclic Compounds Containing Pyrrolo[1,2-a]azepine Fragments.
  191. Environmental Effects on the Fluorescence of the Reaction Products of 2,3-Diphenylquinolizinium Bromide and Amines
  192. Half-Wave Potentials of 1-AZA- and 1,8-Diazaanthraquinones
  193. Corrigendum: Cover Picture: Discovery of a Class of Diketopiperazines as Antiprion Compounds (ChemMedChem 8/2010)
  194. Three-Component, Diastereoselective Synthesis of Highly Functionalized Indane Derivatives Based on an Anionic Domino Sequence from α-Nitroketones
  195. ChemInform Abstract: Cerium(IV) Ammonium Nitrate as a Catalyst in Organic Synthesis
  196. Cover Picture: Discovery of a Class of Diketopiperazines as Antiprion Compounds (ChemMedChem 8/2010)
  197. Synthesis of a Library of 5,6-Unsubstituted 1,4-Dihydropyridines Based on a One-Pot 4CR/Elimination Process and Their Application to the Generation of Structurally Diverse Fused Nitrogen Heterocycles
  198. ChemInform Abstract: Concise Synthesis of Tetrahydro Derivatives of the Pyrido[2,3-b]acridine and Pyrido[3,2-b]acridine Ring Systems.
  199. Discovery of a Class of Diketopiperazines as Antiprion Compounds
  200. ChemInform Abstract: Improvements in the Hetero Diels-Alder Reactions of 1-Dimethylamino-1-azadienes in the Presence of an Electrophilic Scavenger Resin.
  201. ChemInform Abstract: Hetero Diels-Alder Reactions of 1-Acetylamino- and 1-Dimethylamino-1-azadienes with Benzoquinones.
  202. ChemInform Abstract: A New Route Toward 4-Substituted Pyrazino[2,1-b]quinazoline-3,6-dione Systems. Total Synthesis of Glyantrypine.
  203. ChemInform Abstract: (o-Trifluoroacetamido)cinnamaldehyde Dimethylhydrazone, a Useful Azadiene in the Hetero Diels-Alder Approach to the Pyrido[2,3,4-kl]acridine System.
  204. ChemInform Abstract: Versatile Synthesis of Malonamic Acid Derivatives from a β-Ketothioester.
  205. ChemInform Abstract: L-Proline-Catalyzed Three-Component Domino [3 + 2 + 1] Annulation for the Regio- and Diastereoselective Synthesis of Highly Substituted Thienothiopyrans Containing Three or Four Stereocenters.
  206. ChemInform Abstract: Efficient Generation of Highly Functionalized Fused Oxazepine Frameworks Based on a CAN-Catalyzed Four-Component Tetrahydropyridine Synthesis/Ring-Closing Metathesis Sequence.
  207. Cerium(IV) Ammonium Nitrate as a Catalyst in Organic Synthesis
  208. ChemInform Abstract: Vinylation of Nitro-Substituted Indoles, Quinolinones, and Anilides with Grignard Reagents.
  209. ChemInform Abstract: A Mild Protocol for the Efficient Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridines.
  210. ChemInform Abstract: Cerium(IV) Ammonium Nitrate Is an Excellent, General Catalyst for the Friedlaender and Friedlaender—Borsche Quinoline Syntheses: Very Efficient Access to the Antitumor Alkaloid Luotonin A.
  211. Concise and very efficient synthesis of the N-methylwelwistatin tetracyclic core based on an anionic domino process
  212. Expedient, one-pot preparation of fused indoles via CAN-catalyzed three-component domino sequences and their transformation into polyheterocyclic compounds containing pyrrolo[1,2-a]azepine fragments
  213. Multicomponent reactions for the synthesis of pyrroles
  214. ChemInform Abstract: Acid‐Free Synthesis of Carbazoles and Carbazolequinones by Intramolecular Pd‐Catalyzed, Microwave‐Assisted Oxidative Biaryl Coupling Reactions — Efficient Syntheses of Murrayafoline A, 2‐Methoxy‐3‐methylcarbazole, and Glycozolidine.
  215. l-Proline-Catalyzed Three-Component Domino [3+2+1] Annulation for the Regio- and Diastereoselective Synthesis of Highly Substituted Thienothiopyrans Containing Three or Four Stereocenters
  216. Mild and High-Yielding Synthesis of β-Keto Esters and β-Ketoamides
  217. Efficient Generation of Highly Functionalized Fused Oxazepine Frameworks Based on a CAN-Catalyzed Four-Component Tetrahydropyridine Synthesis/Ring-Closing Metathesis Sequence
  218. Vinylation of Nitro-Substituted Indoles, Quinolinones, and Anilides with Grignard Reagents
  219. Acid‐Free Synthesis of Carbazoles and Carbazolequinones by Intramolecular Pd‐Catalyzed, Microwave‐Assisted Oxidative Biaryl Coupling Reactions – Efficient Syntheses of Murrayafoline A, 2‐Methoxy‐3‐methylcarbazole, and Glycozolidine
  220. ChemInform Abstract: A Very Efficient Cerium(IV) Ammonium Nitrate Catalyzed, Four-Component Synthesis of Tetrahydropyridines and Its Application in the Concise Generation of Functionalized Homoquinolizine Frameworks.
  221. A Mild Protocol for the Efficient Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridines
  222. ChemInform Abstract: New Synthetic Approaches to Biologically Relevant Heterocyclic Quinones and Quinoneimines
  223. ChemInform Abstract: Convenient, Two-Step Synthesis of 2-Styrylquinolines: An Application of the CAN-Catalyzed Vinylogous Type-II Povarov Reaction.
  224. Cerium(IV) Ammonium Nitrate Is an Excellent, General Catalyst for the Friedländer and Friedländer−Borsche Quinoline Syntheses: Very Efficient Access to the Antitumor Alkaloid Luotonin A
  225. A Very Efficient Cerium(IV) Ammonium Nitrate Catalyzed, Four-Component Synthesis of Tetrahydropyridines and Its Application in the Concise Generation of Functionalized Homoquinolizine Frameworks
  226. Convenient, two-step synthesis of 2-styrylquinolines: an application of the CAN-catalyzed vinylogous type-II Povarov reaction
  227. ChemInform Abstract: Stereoselective Synthesis of Bicyclo[4.2.1]nonanes - A Temporary-Bridge Approach to Cyclooctanoids.
  228. ChemInform Abstract: Two-Step Stereocontrolled Synthesis of Densely Functionalized Cyclic β-Aminoesters Containing Four Stereocenters, Based on a New Cerium(IV) Ammonium Nitrate Catalyzed Sequential Three-Component Reaction.
  229. Efficient, one-pot transformation of indoles into functionalized oxindole and spirooxindole systems under Swern conditions
  230. Stereoselective Synthesis of Bicyclo[4.2.1]nonanes - a Temporary-Bridge Approach to Cyclooctanoids
  231. ChemInform Abstract: Synthesis of Pyrido[3,2-b]carbazolequinones Involving N-Arylation of 5,8-Dimethoxy-6-nitroquinolines by Aryl Grignard Reagents and a New One-Pot, Palladium-Promoted Oxidative Coupling-Oxidative Demethylation Sequence.
  232. Two-Step Stereocontrolled Synthesis of Densely Functionalized Cyclic β-Aminoesters Containing Four Stereocenters, Based on a New Cerium(IV) Ammonium Nitrate Catalyzed Sequential Three-Component Reaction
  233. ChemInform Abstract: New Findings on the Cerium(IV) Ammonium Nitrate Catalyzed Povarov Reaction: Stereoselective Synthesis of 4-Alkoxy-2-aryl-1,2,3,4-tetrahydroquinoline Derivatives.
  234. Trends in the Design and Application of Optical Chemosensors in Pharmaceutical and Biomedical Analysis
  235. Synthesis of Pyrido[3,2-b]carbazolequinones Involving N-Arylation of 5,8-Dimethoxy-6-nitroquinolines by Aryl Grignard Reagents and a New One-Pot, Palladium-Promoted Oxidative Coupling-Oxidative Demethylation Sequence
  236. ChemInform Abstract: Microwave-Assisted, Solvent-Free Synthesis of Several Quinazoline Alkaloid Frameworks.
  237. ChemInform Abstract: One-Pot Synthesis of Highly Functionalized Oxindoles under Swern Oxidation Conditions.
  238. ChemInform Abstract: The Directed Lithiation Route to 2-Amino-3-alkylquinones: Highly Regioselective Introduction of Electrophiles at the C-7 Position of 2(1H)-Quinolinones.
  239. New Findings on the Cerium(IV) Ammonium Nitrate Catalyzed Povarov Reaction: Stereoselective Synthesis of 4-Alkoxy-2-aryl-1,2,3,4-tetrahydro­quinoline Derivatives
  240. DNA Alkylating Agents
  241. Introduction
  242. Cancer Chemoprevention
  243. Antimetabolites
  244. Preface
  245. DNA Intercalators and Topoisomerase Inhibitors
  246. Anticancer Drugs Targeting Tubulin and Microtubules
  247. Other Approaches to Targeted Therapy
  248. Drug Targeting in Anticancer Chemotherapy
  249. Drugs That Modulate Resistance to Antitumor Agents
  250. Anticancer Drugs That Inhibit Hormone Action
  251. Alkylating and Non-Alkylating Compounds Interacting with the DNA Minor Groove
  252. Drugs That Inhibit Signalling Pathways for Tumor Cell Growth and Proliferation
  253. Anticancer Drugs Acting via Radical Species, Photosensitizers and Photodynamic Therapy of Cancer
  254. Medicinal Chemistry of Anticancer Drugs
  255. Convenient Synthesis of Highly Functionalized, 3,4-Disubstituted Indole Building Blocks
  256. Convenient Synthesis of Highly Functionalized, 3,4-Disubstituted Indole Building Blocks
  257. Microwave-Assisted, Solvent-Free Synthesis of Several Quinazoline Alkaloid Frameworks
  258. One-Pot Synthesis of Highly Functionalized Oxindoles under Swern Oxidation Conditions
  259. The Directed Lithiation Route to 2-Amino-3-alkylquinones: Highly Regioselective Introduction of Electrophiles at the C-7 Position of 2(1H)-Quinolinones
  260. The First Aza Diels—Alder Reaction Involving an α,β-Unsaturated Hydrazone as the Dienophile: Stereoselective Synthesis of C-4 Functionalized 1,2,3,4-Tetrahydroquinolines Containing a Quaternary Stereocenter.
  261. Peptidomimetics in cancer chemotherapy
  262. A New Three-Component Domino Synthesis of 1,4-Dihydropyridines.
  263. CAN-Catalyzed Vinylogous Povarov Reactions: The First Three-Component Synthesis of 2-Functionalized Tetrahydroquinolines from Anilines, Cinnamaldehyde and Vinyl Ethers.
  264. General, Mild and Efficient Synthesis of β-Enaminones Catalyzed by Ceric Ammonium Nitrate.
  265. CAN-Catalyzed Three-Component Reaction Between Anilines and Alkyl Vinyl Ethers: Stereoselective Synthesis of 2-Methyl-1,2,3,4-tetrahydroquinolines and Studies on Their Aromatization.
  266. A new three-component domino synthesis of 1,4-dihydropyridines
  267. CAN-Catalyzed Vinylogous Povarov Reactions: The First Three-Component Synthesis of 2-Functionalized Tetrahydroquinolines from Anilines, ­Cinnamaldehyde and Vinyl Ethers
  268. General, Mild and Efficient Synthesis of β-Enaminones Catalyzed by Ceric Ammonium Nitrate
  269. Changes in the reactivity of the fluorescent reagents carbazole-9-carbonyl chloride and 9-carbazolylacetic acid in the presence of cyclodextrins
  270. Synthesis of Oxygenated Carbazoles by Palladium‐Mediated Oxidative Double C—H Activation of Diarylamines Assisted by Microwave Irradiation.
  271. The first aza Diels–Alder reaction involving an α,β-unsaturated hydrazone as the dienophile: stereoselective synthesis of C-4 functionalized 1,2,3,4-tetrahydroquinolines containing a quaternary stereocenter
  272. CAN-catalyzed three-component reaction between anilines and alkyl vinyl ethers: stereoselective synthesis of 2-methyl-1,2,3,4-tetrahydroquinolines and studies on their aromatization
  273. Structural Studies on Heterocyclic Quinones and Quinonimines
  274. Synthesis of Oxygenated Carbazoles by Palladium-Mediated Oxidative Double C-H Activation of Diarylamines Assisted by Microwave Irradiation
  275. Efficient Synthesis of N -Prenylpyrroloindoline and N -Prenylindole Alkaloids Based on a New Four-Reaction Anionic Domino Process
  276. Multicomponent Reactions
  277. MDR Reversal by Deprenylated Tetracyclic and Hexacyclic Analogues of N-Acetylardeemin: Confirmation of the Ardeemin Pharmacophore
  278. Microwave-Assisted, Solvent-Free Bischler Indole Synthesis.
  279. Microwave-Assisted Synthesis of 2,5-Piperazinediones under Solvent-Free Conditions.
  280. Microwave Assisted Organic Synthesis
  281. Microwave-Assisted, Solvent-Free Bischler Indole Synthesis
  282. Solvent-Free, Efficient Synthesis of 2,5-Piperazinediones from Boc-Protected Dipeptide Esters under Microwave Irradiation.
  283. An Efficient Procedure for the Deprotection of N-Pivaloylindoles, Carbazoles and β-Carbolines with LDA.
  284. Environmental effects on the fluorescence behaviour of carbazole derivatization reagents
  285. Unique Michael Addition-Initiated Domino Reaction for the Stereoselective Synthesis of Functionalized Macrolactones from α-Nitroketones in Water
  286. Microwave-Assisted Synthesis of 2,5-Piperazinediones under Solvent-Free Conditions
  287. An Efficient Procedure for the Deprotection of N -Pivaloylindoles, Carbazoles and β-Carbolines with LDA
  288. Solvent-Free, Efficient Synthesis of 2,5-Piperazinediones from Boc-Protected Dipeptide Esters under Microwave Irradiation
  289. Synthetic Studies on N-Methylwelwitindolinone C Isothiocyanate (Welwistatin) and Related Substructures
  290. Stereoselective Synthesis of Bicyclo[4.2.1]nonane Skeletons by Ring-Closing Metathesis: A New Versatile Methodology for the Efficient Assembly of Functionalized Cyclooctanoids.
  291. Synthesis and Structure—Activity Relationships of 1,5-Diazaanthraquinones as Antitumor Compounds.
  292. Synthesis and biological evaluation of new 1,5-diazaanthraquinones with cytotoxic activity
  293. Solvent-Free Cyclocondensation of Lactim Ethers with Anthranilic Acid under Microwave Irradiation.
  294. Stereoselective Synthesis of Bicyclo[4.2.1]nonane Skeletons by Ring-Closing Metathesis:  A New Versatile Methodology for the Efficient Assembly of Functionalized Cyclooctanoids
  295. Synthesis and structure–activity relationships of 1,5-diazaanthraquinones as antitumour compounds
  296. Practical and User-Friendly Procedure for Michael Reactions of α-Nitroketones in Water.
  297. Brief Total Synthesis of the Cell Cycle Inhibitor Tryprostatin B (I) and Related Preparation of Its Alanine Analogue (II).
  298. Solvent-Free Cyclocondensation of Lactim Ethers with Anthranilic Acid under Microwave Irradiation
  299. Synthetic Studies on N-Methylwelwitindolinone C Isothiocyanate (Welwistatin) and Related Substructures
  300. Regioselective Diels-Alder Reactions of 3-Vinylindoles with Quinones
  301. Efficient Synthesis of the Pyrido[2,3,4-kl]acridin-4-one System Common to Several Cytotoxic Marine Alkaloids.
  302. Brief Total Synthesis of the Cell Cycle Inhibitor Tryprostatin B and Related Preparation of Its Alanine Analogue
  303. Regioselective Diels—Alder Reactions of 3-Indolylquinones.
  304. Detection and characterization of cyclodextrin complexes with β-carboline derivatives by spectroscopic techniques
  305. Efficient synthesis of the pyrido[2,3,4-kl]acridin-4-one system common to several cytotoxic marine alkaloids
  306. Chemistry of Pyrazino[2,1-b]quinazoline-3,6-diones
  307. Regioselective Diels–Alder reactions of 3-indolylquinones
  308. Efficient, Multigram-Scale Synthesis of Three 2,5-Dihalobenzoquinones
  309. Practical and User-Friendly Procedure for Michael Reactions of α-Nitro­ketones in Water
  310. Chemistry of Pyrazino[2,1-b]quinazoline-3,6-diones
  311. Differentiating geometrical isomers of retinoids and controlling their photo-isomerization by complexation with cyclodextrins
  312. EFFICIENT, MULTIGRAM-SCALE SYNTHESIS OF THREE 2,5-DIHALOBENZOQUINONES
  313. Inhibitors of Multidrug Resistance to Antitumor Agents (MDR)
  314. One-pot assembly of large heterocyclic quinones through three-component reactions
  315. Versatile synthesis of malonamic acid derivatives from a β-ketothioester
  316. A C-Ring Regioisomer of the Marine Alkaloid Meridine Exhibits Selective In Vitro Cytotoxicity for Solid Tumours
  317. Hydantoin and Its Derivatives
  318. ChemInform Abstract: Concise Preparation of 1,8-Diazaanthracene-2,7,9,10-tetraones. Two Alternative Syntheses of the Natural Antifolate Diazaquinomycin A.
  319. Concise Preparation of 1,8-Diazaanthracene-2,7,9,10-Tetraones. Two Alternative Syntheses of the Natural Antifolate Diazaquinomycin A
  320. Hetero Diels–Alder Reactions of 1-Acetylamino- and 1-Dimethylamino-1-azadienes with Benzoquinones
  321. A New Route toward 4-Substituted Pyrazino[2,1-b]quinazoline-3,6-dione Systems. Total Synthesis of Glyantrypine
  322. Improvements in the Hetero Diels-Alder Reactions of 1-Dimethylamino-1-azadienes in the Presence of an Electrophilic Scavenger Resin
  323. Synthesis of a Seco Analogue of Ardeemin
  324. ELECTROCHEMICAL EVIDENCE FOR OXO-ENOL TAUTOMERISM OF AZAANTHRACENE-4,9,10-TRIONES
  325. Steric and stereochemical effects on the free-radical bromination of tetracyclic and hexacyclic fragments of the MDR inhibitor N-acetylardeemin
  326. Concise synthesis of tetrahydro derivatives of the pyrido[2,3-b]acridine and pyrido[3,2-b]acridine ring systems
  327. Synthesis of 1,2,3,4-tetrahydroascididemin
  328. Quantitative determination of dimethicone in commercial tablets and capsules by Fourier transform infrared spectroscopy and antifoaming activity test
  329. Comparative study of synthetic approaches to 1-arylmethylenepyrazino[2,1-b]quinazoline-3,6-diones
  330. On the fate of the tryptophan stereocenter during the synthesis of hexacyclic analogues of N-acetylardeemin
  331. Stereochemical issues related to the synthesis and reactivity of pyrazino[2′,1′-5,1]pyrrolo[2,3-b]indole-1,4-diones
  332. A General Synthesis of Quinoline-2,5,8(1H)-triones via Acylation of 2,5-Dimethoxyaniline with S-tert-Butyl Thioacetates by Application of the Knorr Cyclization
  333. Total synthesis of diazaquinomycin A
  334. Hetero Diels-Alder reactions of 4,5,8(1H)-quinolinetriones
  335. A very efficient synthesis of 1,8-diazaanthraquinones
  336. 1,2-Dihydroquinolin-2-one (carbostyril) anions as bidentate nucleophiles in their reactions with aryllead triacetates: synthesis of 1-aryl- and 3-aryl-tetrahydroquinoline-2,5,8-triones
  337. Silica gel-supported hetero Diels-Alder reactions of quinolinetriones
  338. Analytical applications of retinoid—cyclodextrin inclusion complexes
  339. New findings in hetero Diels-Alder reactions of quinolinetriones
  340. Bicyclic 6-6 Systems with One Ring Junction Nitrogen Atom: No Extra Heteroatom
  341. New Synthetic Applications of Aryllead Triacetates. N-Arylation of Amides
  342. New synthetic applications of aryllead triacetates. N-arylation of azoles.
  343. 1-Acylamino-1-azadienes as an alternative to 1-dimethylamino-1-azadienes in the preparation of 1,8-diazaanthracene-2,9,10-triones.
  344. Solvent effects on the fluorescent emission of some new benzimidazole derivatives
  345. Regioselectivity of the Diels-Alder reactions of 2,5,8(1H)-quinolinetriones
  346. Ultrasound assisted Diels-Alder reactions of 1-azadienes with “normal” electronic demand.
  347. Re-examination of the Synthesis of 3,5-Dimethoxy-2-nitrobenzaldehyde
  348. New findings on the Vilsmeier-Haack approach to quinoline derivatives
  349. Amide N-arylation with p-tolyllead triacetate
  350. An Improved Multigram-Scale Preparation ofS-TertButyl Acetothioacetate
  351. N-arylation of azoles and their benzo derivatives by p-tolyllead triacetate
  352. Synthesis, anticonvulsant and antihypertensive activity of diastereomeric 9,10-dimethoxy-1,3,4,6,7,11b-hexahydrospiro-[benzo[a]quinolizin-2,4′-imidazolidine]-2′,5′-diones
  353. Total Synthesis of the Carboxylic Acid lonophore Antibiotic CP-61,405 (Routiennocin): Preparation of the Inherent Spiroketal Unit via a Reverse Coupling Process
  354. Total synthesis of the ionophore antibiotic CP-61,405 (routiennocin)
  355. Synthesis of 1′-substituted and 1′,3′-disubstituted (±)-2R*, 11bS*-9,10-Dimethoxy-1,3,4,6,7,11 b-Hexahydrospiro-[benzo[a]quinolizin-2,5′-imidazolidine]-2′,4′-diones
  356. Study of the Reaction Between Cyanohydrins and Chlorosulfonyl Isocyanate. A New, Efficient Method for the One-Pot Synthesis of 2,4-Oxazolidinediones
  357. The application of ultrasound to the strecker synthesis on 9,10-dimethoxy-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one
  358. Chemistry of the Welwitindolinones