All Stories

  1. Further Studies on the Antiparasitic Activity of Quinoxaline-1,4-di-N-Oxides Containing a Glycine Side Chain
  2. Mechanochemical Reductive Amination of Aldehydes and Ketones: Solid-State Synthesis of the Antiparkinsonian Drugs Rasagiline and Safinamide
  3. 2-Styrylquinolines with Push-Pull Architectures as Sensors for β-Amyloid Aggregation with Theranostic Properties
  4. Regioselective N-2 Alkylation of Tetrazoles with Phenacyl Halides under Mechanochemical Conditions and Its Application to a Solid-State Synthesis of the Antiepileptic Drug Cenobamate
  5. Network-Based Drug Optimization toward the Treatment of Parkinson’s Disease: NRF2, MAO-B, Oxidative Stress, and Chronic Neuroinflammation
  6. Twenty-first century antiepileptic drugs. An overview of their targets and synthetic approaches
  7. Dual Antitubercular and Antileishmanial Profiles of Quinoxaline Di-N-Oxides Containing an Amino Acidic Side Chain
  8. Fluorimetric Detection of Insulin Misfolding by Probes Derived from Functionalized Fluorene Frameworks
  9. Structure-Antitumor Activity Relationships of Aza- and Diaza-Anthracene-2,9,10-Triones and Their Partially Saturated Derivatives
  10. Cyclodextrin Inclusion Complexes for Improved Drug Bioavailability and Activity: Synthetic and Analytical Aspects
  11. Rapid Assembly of Functionalized 2H-Chromenes and 1,2-Dihydroquinolines via Microwave-Assisted Secondary Amine-Catalyzed Cascade Annulation of 2-O/N-Propargylarylaldehydes with 2,6-Dialkylphenols
  12. Quinones as Neuroprotective Agents
  13. m-Terphenylamines, Acting as Selective COX-1 Inhibitors, Block Microglia Inflammatory Response and Exert Neuroprotective Activity
  14. Small-molecule theranostics in Alzheimer's disease
  15. A New Method for the Introduction of an Acylsulfonamide Moiety Applied to a 3-Substituted Functionalized Indole Framework ­Related to the Welwitindolinone Alkaloids
  16. 2-(3-Bromophenyl)imidazo[2,1-b]oxazole
  17. Anticancer drugs acting on signaling pathways, part 1: Tyrosine kinase inhibitors
  18. Anticancer drugs acting on signaling pathways, part 2: Inhibitors of serine-threonine kinases and miscellaneous signaling pathways
  19. Anticancer drugs targeting tubulin and microtubules
  20. Anticancer drugs that interact with the DNA minor groove
  21. Anticancer drugs that modulate hormone action
  22. Anticancer strategies involving radical species
  23. Antimetabolites
  24. Cancer chemoprevention
  25. Cancer immunotherapy
  26. DNA alkylating agents
  27. DNA intercalation and topoisomerase inhibition
  28. Drug targeting in anticancer chemotherapy
  29. Drugs that modulate resistance to antitumor agents
  30. Epigenetic therapy of cancer
  31. General aspects of cancer therapy
  32. Miscellaneous small- molecule and biological approaches to targeted cancer therapy
  33. Protein degradation-based cancer therapy
  34. Small Molecules as Toll-like Receptor 4 Modulators Drug and In-House Computational Repurposing
  35. An Efficient Synthesis of a Highly Functionalized Dihydrobenzo­thiophene Derivative: A Ring-Contracted Analogue of the Anti-inflammatory Drug Propoxicam
  36. Fluorescence Sensors Based on Hydroxycarbazole for the Determination of Neurodegeneration-Related Halide Anions
  37. Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry Perspective
  38. Enantioselective Synthesis and Pharmacological Evaluation of Aza-CGP37157–Lipoic Acid Hybrids for the Treatment of Alzheimer’s Disease
  39. Enantioselective catalytic Povarov reactions
  40. Curcumin-Piperlongumine Hybrids with a Multitarget Profile Elicit Neuroprotection in In Vitro Models of Oxidative Stress and Hyperphosphorylation
  41. Enhanced Stability and Bioactivity of Natural Anticancer Topoisomerase I Inhibitors through Cyclodextrin Complexation
  42. Mechanochemical Synthesis of Primary Amides
  43. Neuroprotective Action of Multitarget 7-Aminophenanthridin-6(5H)-one Derivatives against Metal-Induced Cell Death and Oxidative Stress in SN56 Cells
  44. Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation
  45. (2S*,4S*)-4-[(E)-(2,2-Dimethylhydrazono)methyl]-6-methoxy-4-methyl-2-[(E)-styryl]-1,2,3,4-tetrahydroquinoline
  46. (E)-3-((2-Fluorophenyl)(hydroxy)methylene)imidazo[1,2-a]pyridin-2(3H)-one
  47. Mechanochemical Aza-Vinylogous Povarov Reactions for the Synthesis of Highly Functionalized 1,2,3,4-Tetrahydroquinolines and 1,2,3,4-Tetrahydro-1,5-Naphthyridines
  48. Sustainable Access to Acridin-9-(10H)ones with an Embedded m-Terphenyl Moiety Based on a Three-Component Reaction
  49. Synthesis of 1,4-Diazepanes and Benzo[b][1,4]diazepines by a Domino Process Involving the In Situ Generation of an Aza-Nazarov Reagent
  50. Antioxidant, Anti-inflammatory and Neuroprotective Profiles of Novel 1,4-Dihydropyridine Derivatives for the Treatment of Alzheimer’s Disease
  51. Antioxidants as Molecular Probes: Structurally Novel Dihydro-m-Terphenyls as Turn-On Fluorescence Chemodosimeters for Biologically Relevant Oxidants
  52. NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
  53. D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity
  54. Front Cover: Rearrangement Reactions in Aza-Vinylogous Povarov Products: Metal-Free Synthesis of C3 -Functionalized Quinolines and Studies on their Synthetic Application (Eur. J. Org. Chem. 38/2019)
  55. Proline and its Derivatives as Organocatalysts for Multi‐ Component Reactions in Aqueous Media: Synergic Pathways to the Green Synthesis of Heterocycles
  56. Rearrangement Reactions in Aza-Vinylogous Povarov Products: Metal-Free Synthesis of C3 -Functionalized Quinolines and Studies on their Synthetic Application
  57. Design and synthesis of A- and D ring-modified analogues of luotonin A with reduced planarity
  58. Spirooxindole-pyrrolidine heterocyclic hybrids promotes apoptosis through activation of caspase-3
  59. Structure-activity relationships and mechanistic studies of novel mitochondria-targeted, leishmanicidal derivatives of the 4-aminostyrylquinoline scaffold
  60. Progress in the Chemistry of Tetrahydroquinolines
  61. Diversity‐Oriented Synthesis of Complex Pyrrole‐Based Architectures from Very Simple Starting Materials
  62. Multicomponent domino protocol for the stereoselective synthesis of novel pyrrolo[3,2-c]quinolinone hybrid heterocycles
  63. Heterogeneous Amberlyst-15-catalyzed synthesis of complex hybrid heterocycles containing [1,6]-naphthyridine under metal-free green conditions
  64. Oxidant-free, three-component synthesis of 7-amino-6H-benzo[c]chromen-6-ones under green conditions
  65. The Hantzsch Pyrrole Synthesis: Non-conventional Variations and Applications of a Neglected Classical Reaction
  66. Three-Component Synthesis of a Library of m-Terphenyl Derivatives with Embedded β-Aminoester Moieties
  67. Multicomponent Domino Synthesis, Anticancer Activity and Molecular Modeling Simulation of Complex Dispirooxindolopyrrolidines
  68. Highly functionalized pyrrolidine analogues: stereoselective synthesis and caspase-dependent apoptotic activity
  69. Multicomponent mechanochemical synthesis
  70. A systematic 1 H- and 13 C-NMR spectral analysis of bicyclo[n.3.1]alkanone systems: Determination of the relative configuration of the stereogenic centres and conformation of the six-membered ring
  71. One-Pot Synthesis of Functionalized Carbazoles via a CAN-Catalyzed Multicomponent Process Comprising a C–H Activation Step
  72. Mild and General Synthesis of Pyrrolo[2,1-a]isoquinolines and Related Polyheterocyclic Frameworks from Pyrrole Precursors Derived from a Mechanochemical Multicomponent Reaction
  73. Synthesis of 6,12-Epiminodibenzo[b,f][1,5]diazocines via an Ytterbium Triflate-Catalyzed, AB2 Three-Component Reaction
  74. Three-component synthesis of highly functionalized aziridines containing a peptide side chain and their one-step transformation into β-functionalized α-ketoamides
  75. From Simple Cyclic 1,3-Ketoamides to Complex Spirolactams by Supported Heterogeneous Organocatalysis with PS-BEMP
  76. Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents
  77. One-Pot Access to a Library of Dispiro Oxindole-pyrrolidine/pyrrolothiazole-thiochromane Hybrids via Three-Component 1,3-Dipolar Cycloaddition Reactions
  78. Three-Component Synthesis of Pyrrole-Related Nitrogen Heterocycles by a Hantzsch-Type Process: Comparison between Conventional and High-Speed Vibration Milling Conditions
  79. A Sustainable Approach to the Stereoselective Synthesis of Diazaheptacyclic Cage Systems Based on a Multicomponent Strategy in an Ionic Liquid
  80. ChemInform Abstract: Dipolar Cycloaddition-Based Multicomponent Reactions in Ionic Liquids: A Green, Fully Stereoselective Synthesis of Novel Polycyclic Cage Systems with the Generation of Two New Azaheterocyclic Rings.
  81. ChemInform Abstract: Expedient, Catalyst-Free, Three-Component Synthesis of Fused Tetrahydropyridines in Water.
  82. Efficient synthesis of 2-acylquinolines based on an aza-vinylogous Povarov reaction
  83. Three-component access to 2-pyrrolin-5-ones and their use in target-oriented and diversity-oriented synthesis
  84. Synthesis of 5,6-Dihydrodibenzo[b,h][1,6]naphthyridines via Copper Bromide Catalyzed Intramolecular [4 + 2] Hetero-Diels–Alder Reactions
  85. Straightforward synthesis of pyrrolo[3,4-b]quinolines through intramolecular Povarov reactions
  86. ChemInform Abstract: An Efficient Synthesis of N-Substituted 3-Nitrothiophen-2-amines.
  87. ChemInform Abstract: Highly Efficient Regioselective Synthesis of Pyrroles via a Tandem Enamine Formation-Michael Addition-Cyclization Sequence under Catalyst- and Solvent-Free Conditions.
  88. An efficient synthesis of N-substituted 3-nitrothiophen-2-amines
  89. An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction
  90. ChemInform Abstract: Palladium(II)-Catalyzed Intramolecular Carboxypalladation-Olefin Insertion Cascade: Direct Access to Indeno[1,2-b]furan-2-ones.
  91. Dipolar Cycloaddition-Based Multicomponent Reactions in Ionic Liquids: A Green, Fully Stereoselective Synthesis of Novel Polycyclic Cage Systems with the Generation of Two New Azaheterocyclic Rings
  92. ChemInform Abstract: Lewis Acid-Catalyzed Generation of C-C and C-N Bonds on π-Deficient Heterocyclic Substrates.
  93. Six-Membered Heterocycles
  94. ChemInform Abstract: One-Pot α-Amidosulfone-Mediated Variation of the Pictet-Spengler Tetrahydroisoquinoline Synthesis, Suitable for Amide-Type Substrates.
  95. ChemInform Abstract: A Heavy Metal- and Oxidant-Free, One-Pot Synthesis of Pyridines and Fused Pyridines Based on a Lewis Acid-Catalyzed Multicomponent Reaction.
  96. Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience
  97. Palladium(ii)-catalyzed intramolecular carboxypalladation–olefin insertion cascade: direct access to indeno[1,2-b]furan-2-ones
  98. Highly efficient regioselective synthesis of pyrroles via a tandem enamine formation–Michael addition–cyclization sequence under catalyst- and solvent-free conditions
  99. Cancer Chemoprevention
  100. Preface
  101. DNA Alkylating Agents
  102. Biological Therapy of Cancer
  103. Anticancer Drugs Targeting Tubulin and Microtubules
  104. Drug Targeting in Anticancer Chemotherapy
  105. Anticancer Drugs Acting via Radical Species
  106. Anticancer Drugs That Modulate Hormone Action
  107. Epigenetic Therapy of Cancer
  108. General Aspects of Cancer Chemotherapy
  109. Drugs That Modulate Resistance to Antitumor Agents
  110. Antimetabolites That Interfere with Nucleic Acid Biosynthesis
  111. Other Nonbiological Approaches to Targeted Cancer Chemotherapy
  112. Anticancer Drugs That Interact with the DNA Minor Groove
  113. Other Anticancer Drugs Targeting DNA and DNA-Associated Enzymes
  114. Drugs That Inhibit Signaling Pathways for Tumor Cell Growth and Proliferation
  115. ChemInform Abstract: Fully Diastereoselective Synthesis of Polysubstituted, Functionalized Piperidines and Decahydroquinolines Based on Multicomponent Reactions Catalyzed by Cerium(IV) Ammonium Nitrate.
  116. Expedient, catalyst-free, three-component synthesis of fused tetrahydropyridines in water
  117. Lewis Acid-Catalyzed Generation of CC and CN Bonds on π-Deficient Heterocyclic Substrates
  118. Axial Chirality of 4-Arylpyrazolo[3,4-b]pyridines. Conformational Analysis and Absolute Configuration
  119. ChemInform Abstract: Recent Advances in the Synthesis of Pyrroles by Multicomponent Reactions
  120. One-Pot α-Amidosulfone-Mediated Variation of the Pictet-Spengler Tetrahydroisoquinoline Synthesis, Suitable for Amide-Type Substrates
  121. Fully Diastereoselective Synthesis of Polysubstituted, Functionalized Piperidines and Decahydroquinolines Based on Multicomponent Reactions Catalyzed by Cerium(IV) Ammonium Nitrate
  122. Montmorillonite Clay-Promoted, Solvent-Free Cross-Aldol Condensations under Focused Microwave Irradiation
  123. B-Ring-Aryl Substituted Luotonin A Analogues with a New Binding Mode to the Topoisomerase 1-DNA Complex Show Enhanced Cytotoxic Activity
  124. New 5-Unsubstituted Dihydropyridines with Improved CaV1.3 Selectivity as Potential Neuroprotective Agents against Ischemic Injury
  125. A catalyst-free multicomponent domino sequence for the diastereoselective synthesis of (E)-3-[2-arylcarbonyl-3-(arylamino)allyl]chromen-4-ones
  126. ChemInform Abstract: A β-Enaminone-Initiated Multicomponent Domino Reaction for the Synthesis of Indoloquinolizines and Benzoquinolizines from Acyclic Precursors.
  127. Concise synthesis of atorvastatin lactone under high-speed vibration milling conditions
  128. Recent advances in the synthesis of pyrroles by multicomponent reactions
  129. A heavy metal- and oxidant-free, one-pot synthesis of pyridines and fused pyridines based on a Lewis acid-catalyzed multicomponent reaction
  130. Synthesis of Heterocycles Through Multicomponent Reactions in Water
  131. ChemInform Abstract: A New CAN-Catalyzed Domino Process Related to the Nenitzescu Reaction: Very Concise Access to Fused ortho-Indolequinones from Simple Precursors.
  132. Modulation of Prion by Small Molecules: From Monovalent to Bivalent and Multivalent Ligands
  133. ChemInform Abstract: Chemodivergent, Multicomponent Domino Reactions in Aqueous Media: L-Proline-Catalyzed Assembly of Densely Functionalized 4H-Pyrano[2,3-c]pyrazoles and Bispyrazolyl Propanoates from Simple, Acyclic Starting Materials.
  134. ChemInform Abstract: Michael Additions in Aqueous Media: “On-Water” and “In-Water” Processes from α-Nitro Ketones and Their Anions.
  135. A β-Enaminone-Initiated Multicomponent Domino Reaction for the Synthesis of Indoloquinolizines and Benzoquinolizines from Acyclic Precursors
  136. A new CAN-catalyzed domino process related to the Nenitzescu reaction: very concise access to fused ortho-indolequinones from simple precursors
  137. Editorial (Hot Topic: Multibond Forming Reactions: A New Frontier in the Synthesis of Heterocycles)
  138. L-Proline Catalysed Domino Reactions for the Synthesis of Heterocycles
  139. ChemInform Abstract: Diastereoselective, Multicomponent Access to trans-2-Aryl-4-arylamino-1,2,3,4-tetrahydroquinolines via an AA′BC Sequential Four-Component Reaction and Their Application to 2-Arylquinoline Synthesis.
  140. ChemInform Abstract: Microwave-Assisted, Sequential Four-Component Synthesis of Polysubstituted 5,6-Dihydroquinazolinones (IV) from Acyclic Precursors and a Mild, Halogenation-Initiated Method for Their Aromatization [→(V)] under Focused Microwave Irradia
  141. ChemInform Abstract: Three-Component Access to Pyrroles Promoted by the CAN-Silver Nitrate System under High-Speed Vibration Milling Conditions: A Generalization of the Hantzsch Pyrrole Synthesis.
  142. Synthesis of a D Ring-Functionalized Derivative of the Epiwelwistatin Tetracyclic Core
  143. Michael Additions in Aqueous Media: “On-Water” and “In-Water” Processes from α-Nitro Ketones and Their Anions
  144. ChemInform Abstract: Privileged Scaffolds in Synthesis: 2,5-Piperazinediones as Templates for the Preparation of Structurally Diverse Heterocycles
  145. A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer’s and Prion Diseases
  146. Three-component access to pyrroles promoted by the CAN–silver nitrate system under high-speed vibration milling conditions: a generalization of the Hantzsch pyrrole synthesis
  147. Identification of 4,6-diaryl-1,4-dihydropyridines as a new class of neuroprotective agents
  148. Diastereoselective, multicomponent access to trans-2-aryl-4-arylamino-1,2,3,4-tetrahydroquinolines via an AA′BC sequential four-component reaction and their application to 2-arylquinoline synthesis
  149. Chemodivergent, multicomponent domino reactions in aqueous media: l-proline-catalyzed assembly of densely functionalized 4H-pyrano[2,3-c]pyrazoles and bispyrazolyl propanoates from simple, acyclic starting materials
  150. Microwave-assisted, sequential four-component synthesis of polysubstituted 5,6-dihydroquinazolinones from acyclic precursors and a mild, halogenation-initiated method for their aromatization under focused microwave irradiation
  151. Solvent- and chromatography-free amination of π-deficient nitrogen heterocycles under microwave irradiation. A fast, efficient and green route to 9-aminoacridines, 4-aminoquinolines and 4-aminoquinazolines and its application to the synthesis of the dr...
  152. ChemInform Abstract: Facile Ionic Liquid-Mediated, Three-Component Sequential Reactions for the Green, Regio- and Diastereoselective Synthesis of Furocoumarins.
  153. One-Pot Access to a Library of Structurally Diverse Nicotinamide Derivatives via a Three-Component Formal Aza [3 + 3] Cycloaddition
  154. Fluorescence properties of the anti-tumour alkaloid luotonin A and new synthetic analogues: pH modulation as an approach to their fluorimetric quantitation in biological samples
  155. ChemInform Abstract: Aryl Grignard Reagents in Chemodivergent N- and C-Arylations: Concise Access to Two Families of Tetracyclic Fused Carbazoles from 6-Nitroquinolines.
  156. ChemInform Abstract: Domino Reactions in Water: Diastereoselective Synthesis of Densely Functionalized Indolyldihydrofuran Derivatives.
  157. Facile ionic liquid-mediated, three-component sequential reactions for the green, regio- and diastereoselective synthesis of furocoumarins
  158. ChemInform Abstract: Synthesis of Polysubstituted, Functionalized Quinolines Through a Metal-Free Domino Process Involving a C4-C3Functional Group Rearrangement.
  159. Synthesis of Polysubstituted, Functionalized Quinolines through a Metal-Free Domino Process Involving a C 4 –C 3 Functional Group Rearrangement
  160. Aryl Grignard Reagents in Chemodivergent N- and C-Arylations: Concise Access to Two Families of Tetracyclic Fused Carbazoles from 6-Nitroquinolines
  161. ChemInform Abstract: L-Proline-Catalyzed Sequential Four-Component “On Water” Protocol for the Synthesis of Structurally Complex Heterocyclic ortho-Quinones.
  162. New Types of Reactivity of α,β‐Unsaturated N , N ‐Dimethylhydrazones: Chemodivergent Diastereoselective Synthesis of Functionalized Tetrahydroquinolines and Hexahydropyrrolo[3,2‐ b ...
  163. ChemInform Abstract: A General Protocol for the Solvent- and Catalyst-Free Synthesis of 2-Styrylquinolines under Focused Microwave Irradiation.
  164. ChemInform Abstract: Brief, Efficient and Highly Diastereoselective Synthesis of (.+-.)-Pumiliotoxin C Based on the Generation of an Octahydroquinoline Precursor via a Four-Component Reaction.
  165. ChemInform Abstract: L-Proline-Catalyzed Three-Component Domino Reactions for the Diastereoselective Synthesis of 5,6-Disubstituted 3-Thiomorpholinones.
  166. Privileged scaffolds in synthesis: 2,5-piperazinediones as templates for the preparation of structurally diverse heterocycles
  167. A one-pot sequence for the efficient synthesis of highly functionalized macrocarbocycles or bridged 2,8-dioxabicyclo[3.2.1]octanes from 1-nitrobicyclic compounds
  168. Domino reactions in water: diastereoselective synthesis of densely functionalized indolyldihydrofuran derivatives
  169. A systematic study of two complementary protocols allowing the general, mild and efficient deprotection of N-pivaloylindoles
  170. ChemInform Abstract: Advances in the Chemistry of Tetrahydroquinolines
  171. ChemInform Abstract: A Facile, Three-Component Domino Protocol for the Microwave-Assisted Synthesis of Functionalized Naphtho[2,3-b]furan-4,9-diones in Water.
  172. Advances in the Chemistry of Tetrahydroquinolines
  173. ChemInform Abstract: Domino Reactions for the Synthesis of Bridged Bicyclic Frameworks: Fast Access to Bicyclo[n.3.1]alkanes
  174. A General Protocol for the Solvent- and Catalyst-Free Synthesis of 2-Styrylquinolines under Focused Microwave Irradiation
  175. l-Proline-catalysed three-component domino reactions for the diastereoselective synthesis of 5,6-disubstituted 3-thiomorpholinones
  176. Two chemodivergent anionic domino processes from cyclic α-nitroketones and aromatic aldehydes
  177. ChemInform Abstract: A Facile Three-Component [3 + 2]-Cycloaddition/Annulation Domino Protocol for the Regio- and Diastereoselective Synthesis of Novel Penta- and Hexacyclic Cage Systems, Involving the Generation of Two Heterocyclic Rings and Five Contigu
  178. ChemInform Abstract: Synthesis of Benzo- and Naphtho-Fused Bicyclo[n.3.1]alkane Frameworks with a Bridgehead Nitrogen Function by Palladium-Catalyzed Intramolecular α′-Arylation of α-Nitroketones.
  179. Antimycobacterial activity of novel 1,2,4-oxadiazole-pyranopyridine/chromene hybrids generated by chemoselective 1,3-dipolar cycloadditions of nitrile oxides
  180. ChemInform Abstract: A Three-Component Domino Protocol for the Facile Synthesis of Highly Functionalized Tetrahydroisoquinolines by Creation of Their Benzene Ring.
  181. New four-component reactions in water: a convergent approach to the metal-free synthesis of spiro[indoline/acenaphthylene-3,4′-pyrazolo[3,4-b]pyridine derivatives
  182. A facile three-component [3+2]-cycloaddition/annulation domino protocol for the regio- and diastereoselective synthesis of novel penta- and hexacyclic cage systems, involving the generation of two heterocyclic rings and five contiguous stereocenters
  183. A General, Diastereoselective Synthesis of Highly Functionalized Bicyclo[n.3.1]alkane Systems Based on an Anionic Domino Reaction of α-Nitrocycloalkanones
  184. ChemInform Abstract: CAN-Promoted, Diastereoselective Synthesis of Fused 2,3-Dihydrofurans and Their Transformation into Tetrahydroindoles.
  185. A three-component domino protocol for the facile synthesis of highly functionalized tetrahydroisoquinolines by creation of their benzene ring
  186. ChemInform Abstract: Multicomponent Reactions for the Synthesis of Pyrroles
  187. ChemInform Abstract: Three-Component, Diastereoselective Synthesis of Highly Functionalized Indan Derivatives Based on an Anionic Domino Sequence from α-Nitroketones.
  188. Brief, efficient and highly diastereoselective synthesis of (±)-pumiliotoxin C based on the generation of an octahydroquinoline precursor via a four-component reaction
  189. Domino reactions for the synthesis of bridged bicyclic frameworks: fast access to bicyclo[n.3.1]alkanes
  190. Antimycobacterial activity of spirooxindolo-pyrrolidine, pyrrolizine and pyrrolothiazole hybrids obtained by a three-component regio- and stereoselective 1,3-dipolar cycloaddition
  191. 1,3-Dipolar cycloadditions from tricyclic hemiaminals. Synthesis of the quinocarcin core through catalyst-free generation of azomethine ylides
  192. Synthesis of benzo- and naphtho-fused bicyclo[n.3.1]alkane frameworks with a bridgehead nitrogen function by palladium-catalyzed intramolecular α′-arylation of α-nitroketones
  193. Eco-friendly liquid chromatographic separations based on the use of cyclodextrins as mobile phase additives
  194. l-Proline-catalysed sequential four-component “on water” protocol for the synthesis of structurally complex heterocyclic ortho-quinones
  195. A facile, three-component domino protocol for the microwave-assisted synthesis of functionalized naphtho[2,3-b]furan-4,9-diones in water
  196. CAN-promoted, diastereoselective synthesis of fused 2,3-dihydrofurans and their transformation into tetrahydroindoles
  197. ChemInform Abstract: Expedient, One-Pot Preparation of Fused Indoles via CAN-Catalyzed Three-Component Domino Sequences and Their Transformation into Polyheterocyclic Compounds Containing Pyrrolo[1,2-a]azepine Fragments.
  198. Environmental Effects on the Fluorescence of the Reaction Products of 2,3-Diphenylquinolizinium Bromide and Amines
  199. Half-Wave Potentials of 1-AZA- and 1,8-Diazaanthraquinones
  200. Corrigendum: Cover Picture: Discovery of a Class of Diketopiperazines as Antiprion Compounds (ChemMedChem 8/2010)
  201. Three-Component, Diastereoselective Synthesis of Highly Functionalized Indane Derivatives Based on an Anionic Domino Sequence from α-Nitroketones
  202. ChemInform Abstract: Cerium(IV) Ammonium Nitrate as a Catalyst in Organic Synthesis
  203. Cover Picture: Discovery of a Class of Diketopiperazines as Antiprion Compounds (ChemMedChem 8/2010)
  204. Synthesis of a Library of 5,6-Unsubstituted 1,4-Dihydropyridines Based on a One-Pot 4CR/Elimination Process and Their Application to the Generation of Structurally Diverse Fused Nitrogen Heterocycles
  205. ChemInform Abstract: Concise Synthesis of Tetrahydro Derivatives of the Pyrido[2,3-b]acridine and Pyrido[3,2-b]acridine Ring Systems.
  206. Discovery of a Class of Diketopiperazines as Antiprion Compounds
  207. ChemInform Abstract: Improvements in the Hetero Diels-Alder Reactions of 1-Dimethylamino-1-azadienes in the Presence of an Electrophilic Scavenger Resin.
  208. ChemInform Abstract: Hetero Diels-Alder Reactions of 1-Acetylamino- and 1-Dimethylamino-1-azadienes with Benzoquinones.
  209. ChemInform Abstract: A New Route Toward 4-Substituted Pyrazino[2,1-b]quinazoline-3,6-dione Systems. Total Synthesis of Glyantrypine.
  210. ChemInform Abstract: (o-Trifluoroacetamido)cinnamaldehyde Dimethylhydrazone, a Useful Azadiene in the Hetero Diels-Alder Approach to the Pyrido[2,3,4-kl]acridine System.
  211. ChemInform Abstract: Versatile Synthesis of Malonamic Acid Derivatives from a β-Ketothioester.
  212. ChemInform Abstract: L-Proline-Catalyzed Three-Component Domino [3 + 2 + 1] Annulation for the Regio- and Diastereoselective Synthesis of Highly Substituted Thienothiopyrans Containing Three or Four Stereocenters.
  213. ChemInform Abstract: Efficient Generation of Highly Functionalized Fused Oxazepine Frameworks Based on a CAN-Catalyzed Four-Component Tetrahydropyridine Synthesis/Ring-Closing Metathesis Sequence.
  214. Cerium(IV) Ammonium Nitrate as a Catalyst in Organic Synthesis
  215. ChemInform Abstract: Vinylation of Nitro-Substituted Indoles, Quinolinones, and Anilides with Grignard Reagents.
  216. ChemInform Abstract: A Mild Protocol for the Efficient Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridines.
  217. ChemInform Abstract: Cerium(IV) Ammonium Nitrate Is an Excellent, General Catalyst for the Friedlaender and Friedlaender—Borsche Quinoline Syntheses: Very Efficient Access to the Antitumor Alkaloid Luotonin A.
  218. Concise and very efficient synthesis of the N-methylwelwistatin tetracyclic core based on an anionic domino process
  219. Expedient, one-pot preparation of fused indoles via CAN-catalyzed three-component domino sequences and their transformation into polyheterocyclic compounds containing pyrrolo[1,2-a]azepine fragments
  220. Multicomponent reactions for the synthesis of pyrroles
  221. ChemInform Abstract: Acid‐Free Synthesis of Carbazoles and Carbazolequinones by Intramolecular Pd‐Catalyzed, Microwave‐Assisted Oxidative Biaryl Coupling Reactions — Efficient Syntheses of Murrayafoline A, 2‐Methoxy‐3‐methylcarbazole, and Glycozolidine.
  222. l-Proline-Catalyzed Three-Component Domino [3+2+1] Annulation for the Regio- and Diastereoselective Synthesis of Highly Substituted Thienothiopyrans Containing Three or Four Stereocenters
  223. Mild and High-Yielding Synthesis of β-Keto Esters and β-Ketoamides
  224. Efficient Generation of Highly Functionalized Fused Oxazepine Frameworks Based on a CAN-Catalyzed Four-Component Tetrahydropyridine Synthesis/Ring-Closing Metathesis Sequence
  225. Vinylation of Nitro-Substituted Indoles, Quinolinones, and Anilides with Grignard Reagents
  226. Acid‐Free Synthesis of Carbazoles and Carbazolequinones by Intramolecular Pd‐Catalyzed, Microwave‐Assisted Oxidative Biaryl Coupling Reactions – Efficient Syntheses of Murrayafoline A, 2‐Methoxy‐3‐methylcarbazole, and Glycozolidine
  227. ChemInform Abstract: A Very Efficient Cerium(IV) Ammonium Nitrate Catalyzed, Four-Component Synthesis of Tetrahydropyridines and Its Application in the Concise Generation of Functionalized Homoquinolizine Frameworks.
  228. A Mild Protocol for the Efficient Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridines
  229. ChemInform Abstract: New Synthetic Approaches to Biologically Relevant Heterocyclic Quinones and Quinoneimines
  230. ChemInform Abstract: Convenient, Two-Step Synthesis of 2-Styrylquinolines: An Application of the CAN-Catalyzed Vinylogous Type-II Povarov Reaction.
  231. Cerium(IV) Ammonium Nitrate Is an Excellent, General Catalyst for the Friedländer and Friedländer−Borsche Quinoline Syntheses: Very Efficient Access to the Antitumor Alkaloid Luotonin A
  232. A Very Efficient Cerium(IV) Ammonium Nitrate Catalyzed, Four-Component Synthesis of Tetrahydropyridines and Its Application in the Concise Generation of Functionalized Homoquinolizine Frameworks
  233. Convenient, two-step synthesis of 2-styrylquinolines: an application of the CAN-catalyzed vinylogous type-II Povarov reaction
  234. ChemInform Abstract: Stereoselective Synthesis of Bicyclo[4.2.1]nonanes - A Temporary-Bridge Approach to Cyclooctanoids.
  235. ChemInform Abstract: Two-Step Stereocontrolled Synthesis of Densely Functionalized Cyclic β-Aminoesters Containing Four Stereocenters, Based on a New Cerium(IV) Ammonium Nitrate Catalyzed Sequential Three-Component Reaction.
  236. Efficient, one-pot transformation of indoles into functionalized oxindole and spirooxindole systems under Swern conditions
  237. Stereoselective Synthesis of Bicyclo[4.2.1]nonanes - a Temporary-Bridge Approach to Cyclooctanoids
  238. ChemInform Abstract: Synthesis of Pyrido[3,2-b]carbazolequinones Involving N-Arylation of 5,8-Dimethoxy-6-nitroquinolines by Aryl Grignard Reagents and a New One-Pot, Palladium-Promoted Oxidative Coupling-Oxidative Demethylation Sequence.
  239. Two-Step Stereocontrolled Synthesis of Densely Functionalized Cyclic β-Aminoesters Containing Four Stereocenters, Based on a New Cerium(IV) Ammonium Nitrate Catalyzed Sequential Three-Component Reaction
  240. ChemInform Abstract: New Findings on the Cerium(IV) Ammonium Nitrate Catalyzed Povarov Reaction: Stereoselective Synthesis of 4-Alkoxy-2-aryl-1,2,3,4-tetrahydroquinoline Derivatives.
  241. Trends in the Design and Application of Optical Chemosensors in Pharmaceutical and Biomedical Analysis
  242. Synthesis of Pyrido[3,2-b]carbazolequinones Involving N-Arylation of 5,8-Dimethoxy-6-nitroquinolines by Aryl Grignard Reagents and a New One-Pot, Palladium-Promoted Oxidative Coupling-Oxidative Demethylation Sequence
  243. ChemInform Abstract: Microwave-Assisted, Solvent-Free Synthesis of Several Quinazoline Alkaloid Frameworks.
  244. ChemInform Abstract: One-Pot Synthesis of Highly Functionalized Oxindoles under Swern Oxidation Conditions.
  245. ChemInform Abstract: The Directed Lithiation Route to 2-Amino-3-alkylquinones: Highly Regioselective Introduction of Electrophiles at the C-7 Position of 2(1H)-Quinolinones.
  246. New Findings on the Cerium(IV) Ammonium Nitrate Catalyzed Povarov Reaction: Stereoselective Synthesis of 4-Alkoxy-2-aryl-1,2,3,4-tetrahydro­quinoline Derivatives
  247. DNA Alkylating Agents
  248. Introduction
  249. Cancer Chemoprevention
  250. Antimetabolites
  251. Preface
  252. DNA Intercalators and Topoisomerase Inhibitors
  253. Anticancer Drugs Targeting Tubulin and Microtubules
  254. Other Approaches to Targeted Therapy
  255. Drug Targeting in Anticancer Chemotherapy
  256. Drugs That Modulate Resistance to Antitumor Agents
  257. Anticancer Drugs That Inhibit Hormone Action
  258. Alkylating and Non-Alkylating Compounds Interacting with the DNA Minor Groove
  259. Drugs That Inhibit Signalling Pathways for Tumor Cell Growth and Proliferation
  260. Anticancer Drugs Acting via Radical Species, Photosensitizers and Photodynamic Therapy of Cancer
  261. Medicinal Chemistry of Anticancer Drugs
  262. Convenient Synthesis of Highly Functionalized, 3,4-Disubstituted Indole Building Blocks
  263. Convenient Synthesis of Highly Functionalized, 3,4-Disubstituted Indole Building Blocks
  264. Microwave-Assisted, Solvent-Free Synthesis of Several Quinazoline Alkaloid Frameworks
  265. One-Pot Synthesis of Highly Functionalized Oxindoles under Swern Oxidation Conditions
  266. The Directed Lithiation Route to 2-Amino-3-alkylquinones: Highly Regioselective Introduction of Electrophiles at the C-7 Position of 2(1H)-Quinolinones
  267. The First Aza Diels—Alder Reaction Involving an α,β-Unsaturated Hydrazone as the Dienophile: Stereoselective Synthesis of C-4 Functionalized 1,2,3,4-Tetrahydroquinolines Containing a Quaternary Stereocenter.
  268. Peptidomimetics in cancer chemotherapy
  269. A New Three-Component Domino Synthesis of 1,4-Dihydropyridines.
  270. CAN-Catalyzed Vinylogous Povarov Reactions: The First Three-Component Synthesis of 2-Functionalized Tetrahydroquinolines from Anilines, Cinnamaldehyde and Vinyl Ethers.
  271. General, Mild and Efficient Synthesis of β-Enaminones Catalyzed by Ceric Ammonium Nitrate.
  272. CAN-Catalyzed Three-Component Reaction Between Anilines and Alkyl Vinyl Ethers: Stereoselective Synthesis of 2-Methyl-1,2,3,4-tetrahydroquinolines and Studies on Their Aromatization.
  273. A new three-component domino synthesis of 1,4-dihydropyridines
  274. CAN-Catalyzed Vinylogous Povarov Reactions: The First Three-Component Synthesis of 2-Functionalized Tetrahydroquinolines from Anilines, ­Cinnamaldehyde and Vinyl Ethers
  275. General, Mild and Efficient Synthesis of β-Enaminones Catalyzed by Ceric Ammonium Nitrate
  276. Changes in the reactivity of the fluorescent reagents carbazole-9-carbonyl chloride and 9-carbazolylacetic acid in the presence of cyclodextrins
  277. Synthesis of Oxygenated Carbazoles by Palladium‐Mediated Oxidative Double C—H Activation of Diarylamines Assisted by Microwave Irradiation.
  278. The first aza Diels–Alder reaction involving an α,β-unsaturated hydrazone as the dienophile: stereoselective synthesis of C-4 functionalized 1,2,3,4-tetrahydroquinolines containing a quaternary stereocenter
  279. CAN-catalyzed three-component reaction between anilines and alkyl vinyl ethers: stereoselective synthesis of 2-methyl-1,2,3,4-tetrahydroquinolines and studies on their aromatization
  280. Structural Studies on Heterocyclic Quinones and Quinonimines
  281. Synthesis of Oxygenated Carbazoles by Palladium-Mediated Oxidative Double C-H Activation of Diarylamines Assisted by Microwave Irradiation
  282. Efficient Synthesis of N -Prenylpyrroloindoline and N -Prenylindole Alkaloids Based on a New Four-Reaction Anionic Domino Process
  283. Multicomponent Reactions
  284. MDR Reversal by Deprenylated Tetracyclic and Hexacyclic Analogues of N-Acetylardeemin: Confirmation of the Ardeemin Pharmacophore
  285. Microwave-Assisted, Solvent-Free Bischler Indole Synthesis.
  286. Microwave-Assisted Synthesis of 2,5-Piperazinediones under Solvent-Free Conditions.
  287. Microwave Assisted Organic Synthesis
  288. Microwave-Assisted, Solvent-Free Bischler Indole Synthesis
  289. Solvent-Free, Efficient Synthesis of 2,5-Piperazinediones from Boc-Protected Dipeptide Esters under Microwave Irradiation.
  290. An Efficient Procedure for the Deprotection of N-Pivaloylindoles, Carbazoles and β-Carbolines with LDA.
  291. Environmental effects on the fluorescence behaviour of carbazole derivatization reagents
  292. Unique Michael Addition-Initiated Domino Reaction for the Stereoselective Synthesis of Functionalized Macrolactones from α-Nitroketones in Water
  293. Microwave-Assisted Synthesis of 2,5-Piperazinediones under Solvent-Free Conditions
  294. An Efficient Procedure for the Deprotection of N -Pivaloylindoles, Carbazoles and β-Carbolines with LDA
  295. Solvent-Free, Efficient Synthesis of 2,5-Piperazinediones from Boc-Protected Dipeptide Esters under Microwave Irradiation
  296. Synthetic Studies on N-Methylwelwitindolinone C Isothiocyanate (Welwistatin) and Related Substructures
  297. Stereoselective Synthesis of Bicyclo[4.2.1]nonane Skeletons by Ring-Closing Metathesis: A New Versatile Methodology for the Efficient Assembly of Functionalized Cyclooctanoids.
  298. Synthesis and Structure—Activity Relationships of 1,5-Diazaanthraquinones as Antitumor Compounds.
  299. Synthesis and biological evaluation of new 1,5-diazaanthraquinones with cytotoxic activity
  300. Solvent-Free Cyclocondensation of Lactim Ethers with Anthranilic Acid under Microwave Irradiation.
  301. Stereoselective Synthesis of Bicyclo[4.2.1]nonane Skeletons by Ring-Closing Metathesis:  A New Versatile Methodology for the Efficient Assembly of Functionalized Cyclooctanoids
  302. Synthesis and structure–activity relationships of 1,5-diazaanthraquinones as antitumour compounds
  303. Practical and User-Friendly Procedure for Michael Reactions of α-Nitroketones in Water.
  304. Brief Total Synthesis of the Cell Cycle Inhibitor Tryprostatin B (I) and Related Preparation of Its Alanine Analogue (II).
  305. Solvent-Free Cyclocondensation of Lactim Ethers with Anthranilic Acid under Microwave Irradiation
  306. Synthetic Studies on N-Methylwelwitindolinone C Isothiocyanate (Welwistatin) and Related Substructures
  307. Regioselective Diels-Alder Reactions of 3-Vinylindoles with Quinones
  308. Efficient Synthesis of the Pyrido[2,3,4-kl]acridin-4-one System Common to Several Cytotoxic Marine Alkaloids.
  309. Brief Total Synthesis of the Cell Cycle Inhibitor Tryprostatin B and Related Preparation of Its Alanine Analogue
  310. Regioselective Diels—Alder Reactions of 3-Indolylquinones.
  311. Detection and characterization of cyclodextrin complexes with β-carboline derivatives by spectroscopic techniques
  312. Efficient synthesis of the pyrido[2,3,4-kl]acridin-4-one system common to several cytotoxic marine alkaloids
  313. Chemistry of Pyrazino[2,1-b]quinazoline-3,6-diones
  314. Regioselective Diels–Alder reactions of 3-indolylquinones
  315. Efficient, Multigram-Scale Synthesis of Three 2,5-Dihalobenzoquinones
  316. Practical and User-Friendly Procedure for Michael Reactions of α-Nitro­ketones in Water
  317. Chemistry of Pyrazino[2,1-b]quinazoline-3,6-diones
  318. Differentiating geometrical isomers of retinoids and controlling their photo-isomerization by complexation with cyclodextrins
  319. EFFICIENT, MULTIGRAM-SCALE SYNTHESIS OF THREE 2,5-DIHALOBENZOQUINONES
  320. Inhibitors of Multidrug Resistance to Antitumor Agents (MDR)
  321. One-pot assembly of large heterocyclic quinones through three-component reactions
  322. Versatile synthesis of malonamic acid derivatives from a β-ketothioester
  323. A C-Ring Regioisomer of the Marine Alkaloid Meridine Exhibits Selective In Vitro Cytotoxicity for Solid Tumours
  324. Hydantoin and Its Derivatives
  325. ChemInform Abstract: Concise Preparation of 1,8-Diazaanthracene-2,7,9,10-tetraones. Two Alternative Syntheses of the Natural Antifolate Diazaquinomycin A.
  326. Concise Preparation of 1,8-Diazaanthracene-2,7,9,10-Tetraones. Two Alternative Syntheses of the Natural Antifolate Diazaquinomycin A
  327. Hetero Diels–Alder Reactions of 1-Acetylamino- and 1-Dimethylamino-1-azadienes with Benzoquinones
  328. A New Route toward 4-Substituted Pyrazino[2,1-b]quinazoline-3,6-dione Systems. Total Synthesis of Glyantrypine
  329. Improvements in the Hetero Diels-Alder Reactions of 1-Dimethylamino-1-azadienes in the Presence of an Electrophilic Scavenger Resin
  330. Synthesis of a Seco Analogue of Ardeemin
  331. ELECTROCHEMICAL EVIDENCE FOR OXO-ENOL TAUTOMERISM OF AZAANTHRACENE-4,9,10-TRIONES
  332. Steric and stereochemical effects on the free-radical bromination of tetracyclic and hexacyclic fragments of the MDR inhibitor N-acetylardeemin
  333. Concise synthesis of tetrahydro derivatives of the pyrido[2,3-b]acridine and pyrido[3,2-b]acridine ring systems
  334. Synthesis of 1,2,3,4-tetrahydroascididemin
  335. Quantitative determination of dimethicone in commercial tablets and capsules by Fourier transform infrared spectroscopy and antifoaming activity test
  336. Comparative study of synthetic approaches to 1-arylmethylenepyrazino[2,1-b]quinazoline-3,6-diones
  337. On the fate of the tryptophan stereocenter during the synthesis of hexacyclic analogues of N-acetylardeemin
  338. Stereochemical issues related to the synthesis and reactivity of pyrazino[2′,1′-5,1]pyrrolo[2,3-b]indole-1,4-diones
  339. A General Synthesis of Quinoline-2,5,8(1H)-triones via Acylation of 2,5-Dimethoxyaniline with S-tert-Butyl Thioacetates by Application of the Knorr Cyclization
  340. Total synthesis of diazaquinomycin A
  341. Hetero Diels-Alder reactions of 4,5,8(1H)-quinolinetriones
  342. A very efficient synthesis of 1,8-diazaanthraquinones
  343. 1,2-Dihydroquinolin-2-one (carbostyril) anions as bidentate nucleophiles in their reactions with aryllead triacetates: synthesis of 1-aryl- and 3-aryl-tetrahydroquinoline-2,5,8-triones
  344. Silica gel-supported hetero Diels-Alder reactions of quinolinetriones
  345. Analytical applications of retinoid—cyclodextrin inclusion complexes
  346. New findings in hetero Diels-Alder reactions of quinolinetriones
  347. Bicyclic 6-6 Systems with One Ring Junction Nitrogen Atom: No Extra Heteroatom
  348. New Synthetic Applications of Aryllead Triacetates. N-Arylation of Amides
  349. New synthetic applications of aryllead triacetates. N-arylation of azoles.
  350. 1-Acylamino-1-azadienes as an alternative to 1-dimethylamino-1-azadienes in the preparation of 1,8-diazaanthracene-2,9,10-triones.
  351. Solvent effects on the fluorescent emission of some new benzimidazole derivatives
  352. Regioselectivity of the Diels-Alder reactions of 2,5,8(1H)-quinolinetriones
  353. Ultrasound assisted Diels-Alder reactions of 1-azadienes with “normal” electronic demand.
  354. Re-examination of the Synthesis of 3,5-Dimethoxy-2-nitrobenzaldehyde
  355. New findings on the Vilsmeier-Haack approach to quinoline derivatives
  356. Amide N-arylation with p-tolyllead triacetate
  357. An Improved Multigram-Scale Preparation ofS-TertButyl Acetothioacetate
  358. N-arylation of azoles and their benzo derivatives by p-tolyllead triacetate
  359. Synthesis, anticonvulsant and antihypertensive activity of diastereomeric 9,10-dimethoxy-1,3,4,6,7,11b-hexahydrospiro-[benzo[a]quinolizin-2,4′-imidazolidine]-2′,5′-diones
  360. Total Synthesis of the Carboxylic Acid lonophore Antibiotic CP-61,405 (Routiennocin): Preparation of the Inherent Spiroketal Unit via a Reverse Coupling Process
  361. Total synthesis of the ionophore antibiotic CP-61,405 (routiennocin)
  362. Synthesis of 1′-substituted and 1′,3′-disubstituted (±)-2R*, 11bS*-9,10-Dimethoxy-1,3,4,6,7,11 b-Hexahydrospiro-[benzo[a]quinolizin-2,5′-imidazolidine]-2′,4′-diones
  363. Study of the Reaction Between Cyanohydrins and Chlorosulfonyl Isocyanate. A New, Efficient Method for the One-Pot Synthesis of 2,4-Oxazolidinediones
  364. The application of ultrasound to the strecker synthesis on 9,10-dimethoxy-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one
  365. Chemistry of the Welwitindolinones