How the DNA of elderly people changes so their bodies are getting old?

What is it about?

**This chapter hypothesized how our bodies are getting old and proposed a possibility to reverse it.** When we are getting old, our bodies become deteriorated and prone to have a number of non-communicable diseases such as essential hypertension, cancer, osteoporosis or losing bone mass, increasing cholesterol, loss of brain function and loss of heart function etc. This aging process is caused by our DNA losses certain epigenetic properties. Consequently, our genome becomes unstable and spontaneously accumulates DNA damage. Here I described the epigenetic marks that prevent genomic instability in the elderly. Molecular editing to increase these epigenetic marks reduces DNA damage and improves cellular function.

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Why is it important?

This chapter hypothesizes a main pathogenesis mechanism of non-communicable diseases such as essential hypertension, cancer, osteoporosis or losing bone mass, increasing cholesterol, loss of brain function and loss of heart function etc. Understand this mechanism will be a crucial clue to cure body deteriorations from aging process.

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