The Injectable rhBMP-2-containing Collagen Gel for Tendon Healing in a Rabbit Extra-Articular Bone Tunnel Model

Kwang-Il Lee, Ju-Woong Jang, Kwang-Won Lee
  • December 2019, InTech
  • DOI: 10.5772/intechopen.82471

Extra-articular bone tunnel model

What is it about?

The Injectable rhBMP-2-containing Collagen Gel for Tendon Healing in a Rabbit Extra-Articular Bone Tunnel Model

Why is it important?

This rabbit animal study has a hypothesis that the collagen gel, which is injectable easily, can be an effective carrier for recombinant human bone morphogenetic protein 2 (rhBMP-2) for the tendon healing in a bone tunnel. The cut upper long digital extensor tendon of each rabbit was inserted into the proximal tibia bone tunnel, and rhBMP-2 conjugated collagen gel was injected into the tendon-bone tunnel interface using a syringe. Biomechanical and histological performances were analyzed at 3 and 6 weeks after surgery. The collagen sol at room temperature was transformed to a gel at 37°C. The rhBMP-2 was slowly released from the collagen gel for more than 4 weeks. The in vivo experiment showed the enhanced new fibrocartilage and bone tissue formation at 6 weeks after injecting the rhBMP-2-containing collagen gel. The calcification and enthesis-like tissue were detected radiologically in the repaired tendon-bone junction. The viscous collagen gel-containing rhBMP-2 increased the fusion rate of the repaired tendon in the bone tunnel.

Perspectives

Dr. Kwang il Lee
The Scripps Research Institute

This study showed that viscous collagen gel can be an effective carrier for rhBMP-2 for tendon healing in the bone tunnel. The rhBMP-2-containing collagen gel will be promising for tendon-bone interface healing in the future.

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http://dx.doi.org/10.5772/intechopen.82471

The following have contributed to this page: Dr. Kwang il Lee