rhBMP-2-Coated Acellular Dermal Graft for Chronic Rotator Cuff Healing: Translational Tendon Repair Research

Kwang-Il Lee, Ju-Woong Jang, Kwang-Won Lee
  • November 2019, InTech
  • DOI: 10.5772/intechopen.82282

Translational tendon repair research

What is it about?

rhBMP-2-Coated Acellular Dermal Graft for Chronic Rotator Cuff Healing

Why is it important?

A rotator cuff tear is a common shoulder injury in sports medicine. However, a rotator cuff repair still has the high failure rate (57%) in large torn (>8 cm2) rotator cuff cases. One of the main reasons is failing at suture-tendon cause of continuous tensional and torsional stresses even after surgery, and thus, an ideal biologic augmentation to overcome large tears is an essential challenge. The ECM graft, the biological material can be useful for augment repair of large torn rotator cuff. Recombinant human bone morphogenetic protein 2 (rhBMP-2), which belongs to transforming growth factor-β superfamily, is well known as an osteoinductive growth factor. It plays an important role in the development of bone and cartilage. rhBMP-2 also facilitates chemotaxis in the host tissue. In this study, rhBMP-2-coated acellular dermal graft, which is isolated from human cadaveric donor, was transplanted in the rabbit with the chronic rotator cuff injury. The radiologic image, histomorphometric, histologic image analyses, and tensile test were performed to evaluate the effectiveness.


Dr. Kwang il Lee
The Scripps Research Institute

The results showed the enhancement of increased host cell infiltration, new bone formation, and tensile mechanical property. The rhBMP-2-coated acellular dermal graft will be promising for chronic rotator cuff healing.

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The following have contributed to this page: Dr. Kwang il Lee