Can a Nation be forced to be part of a larger polity?

What is it about?

This is about claims to secession, through the democratic exercise of the right to decide or of self-determination, made by Nations or national regions in order to sever themselves from a larger State (Member State of the EU) in which they are constitutionally locked-in for different reasons. A powerful argument for secession is that it would be contrary to democratic principles to force these regions or nations to form part of the larger Nation-State without giving them a chance to decide on this status.

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Why is it important?

This problem situation concerns the claims made by many people in different narional regions in Europe (Scotland, Northern Ireland, Quebec, Catalonia, Corsica, Wales, ...), the Americas, and all over the world