Centrosomal AKAP350 modulates the G1/S transition

What is it about?

AKAP350 is a scaffold protein that nucleates signalling proteins including PKA,localizing them to specific cell locations. In the present work we describe that AKAP350 regulates the G1/S transition by coordinating the activity of proteins involved in multiple events required for the initiation of both DNA synthesis and centrosomal duplication. More specifically, AKAP350 recruits the mitotic kinase Cdk2 to the centrosome, thus facilitating the phosphorylation of substrates such as nucleophosmin, which are essential in centrosomal duplication.

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Why is it important?

Understanding the events that govern the G1/S transition is fundamental for comprehension of how cells control their proliferation rate and the accuracy of chromosome segregation.