What is it about?
Hydrophilic matrix tablets represent a widely used technology for oral controlled release formulations. Understanding the interplay of factors that control drug release in these systems and awareness of the tools available to explore these is important to designing optimally-performing products. This review shares current knowledge in this field.
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Why is it important?
Hydrophilic matrix tablets are frequently used to provide for oral controlled release drug products. Rapid, rational design of these products can be achieved through proper understanding of how rate of drug release can be modulated. Evolution of tools to develop this understanding has continued and this review brings this together along with perspectives on how to use them and the information they can provide.
Perspectives
The review not only provides an update of current literature but includes a personal view of how to use understanding of rate control mechanisms to rapidly produce early prototype products for clinical investigation.
Prof Peter Timmins
University of Huddersfield
Read the Original
This page is a summary of: Advances in mechanistic understanding of release rate control mechanisms of extended-release hydrophilic matrix tablets, Therapeutic Delivery, August 2016, Future Science,
DOI: 10.4155/tde-2016-0026.
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