What is it about?
A sensitive bioanalytical method using peptide nucleic acid-fluorescence probe and HPLC analysis was developed and validated according to FDA/EMA guidance on bioanalytical method validation. The method provides 3-fold dynamic range and only requires 25 microliter of plasma sample. The validated method was successfully applied to support toxicokinetic sample analyses.
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This page is a summary of: Quantitative Determination of A Sirna (Ad00370) in Rat Plasma Using Peptide Nucleic Acid Probe and HPLC with Fluorescence Detection, Bioanalysis, June 2017, Taylor & Francis,
DOI: 10.4155/bio-2017-0017.
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