What is it about?

This paper describes the repositioning of known drugs using computational methods. We used ligand and sctructure based virtual screening approaches. This furnished us the identification of 7 drugs approved for other therapies which could have potential to also treat COVID-19.

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Why is it important?

Finding drug-based therapies to treat COVID-19 would increase the success of preventing symptoms, reduce the number of deaths, and combating this pandemic that represents a global health issue.


I hope that the drugs revealed in this paper are soon to be effective in experimental assays which are ongoing. Also that the findings presented here produce a significant impact in drug design subjects, as well as related science fields, which has been striving to aid the world from this harmful pandemic.

Guilherme Martins Silva
Harvard Medical School

Read the Original

This page is a summary of: Identification of known drugs as potential SARS-CoV-2 Mpro inhibitors using ligand- and structure-based virtual screening, Future Medicinal Chemistry, June 2021, Future Science,
DOI: 10.4155/fmc-2021-0025.
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