What is it about?

Various tear proteins have been used to detect a change in lacrimal function or increase in inflammation. These include alarmins, tear enzymes, antimicrobial peptides, differentiation related proteins, immunoglobulins, etc.

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Why is it important?

Since dry eye symptoms don't correlate well with clinical signs like corneal staining, it is good to have a more objective parameter that is correlated to treatable underlying pathology.


Use of point of care devices (eg., laminar flow devices) has made the development of biomarkers more relevant and useful.

Prof Louis Tong
National University of Singapore

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This page is a summary of: Role of tear film biomarkers in the diagnosis and management of dry eye disease, Taiwan Journal of Ophthalmology, January 2019, Medknow, DOI: 10.4103/tjo.tjo_56_19.
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