Antiviral agents derived from novel 1-adamantyl singlet nitrenes

Andreas J Kesel, Hans-Christoph Weiss, Andreas Schönleber, Craig W Day, Dale L Barnard, Mervi A Detorio, Raymond F Schinazi
  • Antiviral Chemistry and Chemotherapy, January 2012, International Medical Press
  • DOI: 10.3851/imp2485

1-adamantanammonium 4-fluorobenzoate and 1,4-bis(4-methoxyphenyl)butane-1,4-dione

What is it about?

Synthesis as well as molecular and crystal structures of both compounds are presented and discussed.

Why is it important?

These two aromatic-aliphatic ketone-stabilized 1-adamantyl singlet nitrenes can serve as versatile synthons for the synthesis of new amantadine-related potentially antiviral drugs.

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http://dx.doi.org/10.3851/imp2485

The following have contributed to this page: Priv.-Doz. Dr. Andreas Schönleber