What is it about?
The high complexity involved in the understanding of how these driver mutations and epigenome events dys-regulate critical cell signalling pathways, biomolecular networks, and biologic systems homeostasis leading to tumorigenesis explains the current limitations in personalized risk assessment and prevention of the disease.
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Why is it important?
Substantial progress in detecting breast cancer at an early stage has been made over recent decades. Mam-mographic breast screening in the general population and BRCA1/2 mutation testing in the subpopulation of women with significant family history of breast and ovarian cancer represent two prime paradigms of clinical success. However, breast cancer continues to be the most common female cancer, and mortality remains high.
Perspectives
Whether all these problems can be resolved by using next-generation sequencing for exome and whole-genome sequencing and rapid advances in systems and synthetic biology for predicting biomolecular networks will result in the discovery of novel robust biomarkers for early detection at a very early stage in asymptomatic women and new preventive drugs is still unknown.
Dr Demosthenes E. Ziogas
Peripheral General Hospital of Ioannina - Xatzikosta
Read the Original
This page is a summary of: Risk factors and early detection of breast cancer: facts, questions, and genome-based perspectives, Current Oncology, June 2012, MultiMed Inc.,
DOI: 10.3747/co.19.991.
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