What is it about?
This study demonstrates that the five-element ORBIT bleeding score which has been reported to have better ability to predict major bleeding in AF patients as compared with HAS-BLED and ATRIA risk scores, is associated with enhanced fibrinolysis and looser clot structure, which renders it prone to fragmentation.
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Why is it important?
Our study supports the concept of a complex clinical and biomarker-based approach in the bleeding risk assessment in patients with atrial fibrillation. This finding extends our previous studies regarding plasma fibrin clot density and lysability in AF.
Perspectives
This hypothesis-generating report suggests that tendency to form looser and more lysable fibrin clots can be observed in patients with high bleeding risk assessed by ORBIT score.
Leszek Drabik
Uniwersytet Jagiellonski w Krakowie
Read the Original
This page is a summary of: The ORBIT bleeding score is associated with lysis and permeability of fibrin clots, Kardiologia Polska, October 2019, Polskie Towarzystwo Kardiologiczne,
DOI: 10.33963/kp.15020.
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