What is it about?
Gnotobiotic pig model is the most robust platform for testing antiviral drugs and vaccine candidates. In this article, we comprehensively reviewed all the published work involving using gnotobiotic pigs for the study of human noroviruses GII variants.
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Why is it important?
Gnotobiotic pigs are the most human-like animal model that fully recapitulates all aspects of human norovirus (HuNoV) infection. None of the lower-order species develop diarrhea after inoculation with HuNoV. From elucidating viral tropism to unraveling immune responses, the insights gained from the pig model hold significant promise for translational applications.
Perspectives
My lab has studied human noroviruses using gnotobiotic pig model for over 16 years. We are making great efforts to improve the reliability of the model system. This review provides comprehensive information on the current state of the model. We believe that the well-established pig model will greatly facilitate the development of human norovirus vaccines and anti-viral drugs.
Dr Lijuan Yuan
Virginia Polytechnic Institute and State University
Read the Original
This page is a summary of: Virus Shedding and Diarrhea: A Review of Human Norovirus Genogroup II Infection in Gnotobiotic Pigs, Viruses, September 2024, MDPI AG,
DOI: 10.3390/v16091432.
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