All Stories

  1. Gnotobiotic pig model of human norovirus infection and disease

    Article • Viruses, September 2024, MDPI AG

    Dr Lijuan Yuan

  2. Probiotic as Adjuvant Significantly Improves Protection of the Lanzhou Trivalent Rotavirus Vaccine against Heterologous Challenge in a Gnotobiotic Pig Model of Human Rotavirus Infection and Disease

    Article • Vaccines, September 2022, MDPI AG

    Dr Lijuan Yuan

  3. Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease

    Article • Gut Pathogens, June 2022, Springer Science + Business Media

    Dr Lijuan Yuan

  4. Introduction

    Article • March 2022, Taylor & Francis

    Dr Lijuan Yuan

  5. Simvastatin Reduces Protection and Intestinal T Cell Responses Induced by a Norovirus P Particle Vaccine in Gnotobiotic Pigs

    Article • Pathogens, July 2021, MDPI AG

    Dr Lijuan Yuan

  6. Thermostable, Dissolvable Buccal Film Rotavirus Vaccine Is Highly Effective in Neonatal Gnotobiotic Pig Challenge Model

    Article • Vaccines, April 2021, MDPI AG

    Dr Lijuan Yuan

  7. Evaluation of the 50% Infectious Dose of Human Norovirus Cin-2 in Gnotobiotic Pigs: A Comparison of Classical and Contemporary Methods for Endpoint Estimation

    Article • Viruses, August 2020, MDPI AG

    Philip Schmidt, Dr Lijuan Yuan

  8. Rotavirus

    Article • October 2018, Taylor & Francis

    Dr Lijuan Yuan

  9. Infection Dynamics of Hepatitis E Virus in Wild-Type and Immunoglobulin Heavy Chain Knockout JH−/− Gnotobiotic Piglets

    Article • Journal of Virology, August 2018, ASM Journals

    Dr Lijuan Yuan

  10. Immunomodulation and signaling mechanism of Lactobacillus rhamnosus GG and its components on porcine intestinal epithelial cells stimulated by lipopolysaccharide

    Article • Journal of Microbiology Immunology and Infection, October 2017, Elsevier

    Dr Lijuan Yuan

  11. Pig model mimicking chronic hepatitis E virus infection in immunocompromised patients to assess immune correlates during chronicity

    Article • Proceedings of the National Academy of Sciences, June 2017, Proceedings of the National Academy of Sciences

    Dr Lijuan Yuan

  12. Rotavirus

    Article • March 2017, Taylor & Francis

    Dr Lijuan Yuan

  13. Gnotobiotic Pigs

    Article • January 2017, Elsevier

    Dr Lijuan Yuan

  14. Real-time PCR-based infectivity assay for the titration of turkey hemorrhagic enteritis virus, an adenovirus, in live vaccines

    Article • Journal of Virological Methods, January 2017, Elsevier

    Dr Lijuan Yuan

  15. Lactobacillus rhamnosus GG modulates innate signaling pathway and cytokine responses to rotavirus vaccine in intestinal mononuclear cells of gnotobiotic pigs transplanted with human gut microbiota

    Article • BMC Microbiology, June 2016, Springer Science + Business Media

    Dr Lijuan Yuan

  16. Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency

    Article • Scientific Reports, April 2016, Springer Science + Business Media

    Dr Lijuan Yuan

  17. Enterobacter cloacae inhibits human norovirus infectivity in gnotobiotic pigs

    Article • Scientific Reports, April 2016, Springer Science + Business Media

    Dr Lijuan Yuan

  18. B-Cell-Deficient and CD8 T-Cell-Depleted Gnotobiotic Pigs for the Study of Human Rotavirus Vaccine-Induced Protective Immune Responses

    Article • Viral Immunology, March 2016, Mary Ann Liebert Inc

    Dr Lijuan Yuan

  19. High protective efficacy of rice bran against human rotavirus diarrhea via enhancing probiotic growth, gut barrier function and innate immunity

    Article • Scientific Reports, October 2015, Springer Science + Business Media

    Dr Lijuan Yuan

  20. Norovirus Vaccines and Potential Antinorovirus Drugs: Recent Advances and Future Perspectives

    Article • Future Virology, July 2015, Taylor & Francis

    Dr Lijuan Yuan

  21. Tandem truncated rotavirus VP8* subunit protein with T cell epitope as non-replicating parenteral vaccine is highly immunogenic

    Article • Human Vaccines & Immunotherapeutics, June 2015, Taylor & Francis

    Dr Lijuan Yuan

  22. Lactobacillus rhamnosus GG Dosage Affects the Adjuvanticity and Protection Against Rotavirus Diarrhea in Gnotobiotic Pigs

    Article • Journal of Pediatric Gastroenterology and Nutrition, June 2015, Wiley

    Dr Lijuan Yuan

  23. Cloning and nucleotide sequence analyses of 11 genome segments of two American and one British equine rotavirus strains

    Article • Veterinary Microbiology, March 2015, Elsevier

    Dr Lijuan Yuan

  24. Probiotics and virulent human rotavirus modulate the transplanted human gut microbiota in gnotobiotic pigs

    Article • Gut Pathogens, September 2014, Springer Science + Business Media

    Dr Lijuan Yuan

  25. Dietary Rice Bran Protects against Rotavirus Diarrhea and Promotes Th1-Type Immune Responses to Human Rotavirus Vaccine in Gnotobiotic Pigs

    Article • Clinical and Vaccine Immunology, July 2014, ASM Journals

    Dr Lijuan Yuan

  26. P2-VP8* rotavirus vaccine

    Article • Vaccine, July 2014, Elsevier

    Dr Lijuan Yuan

  27. Intranasal P Particle Vaccine Provided Partial Cross-Variant Protection against Human GII.4 Norovirus Diarrhea in Gnotobiotic Pigs

    Article • Journal of Virology, June 2014, ASM Journals

    Dr Lijuan Yuan

  28. Probiotic Lactobacillus rhamnosus GG Enhanced Th1 Cellular Immunity but Did Not Affect Antibody Responses in a Human Gut Microbiota Transplanted Neonatal Gnotobiotic Pig Model

    Article • PLOS One, April 2014, PLOS

    Dr Lijuan Yuan

  29. Dual Functions of Lactobacillus acidophilus NCFM as Protection Against Rotavirus Diarrhea

    Article • Journal of Pediatric Gastroenterology and Nutrition, February 2014, Wiley

    Dr Lijuan Yuan

  30. Consensus sequence determination and elucidation of the evolutionary history of a rotavirus Wa variant reveal a close relationship to various Wa variants derived from the original Wa strain

    Article • Infection Genetics and Evolution, December 2013, Elsevier

    Dr Lijuan Yuan

  31. Lactobacillus rhamnosus GG on Rotavirus‐Induced Injury of Ileal Epithelium in Gnotobiotic Pigs

    Article • Journal of Pediatric Gastroenterology and Nutrition, December 2013, Wiley

    Dr Lijuan Yuan

  32. Median infectious dose of human norovirus GII.4 in gnotobiotic pigs is decreased by simvastatin treatment and increased by age

    Article • Journal of General Virology, September 2013, Society for General Microbiology

    Dr Lijuan Yuan

  33. Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine

    Article • Gut Pathogens, August 2013, Springer Science + Business Media

    Dr Lijuan Yuan

  34. Nutritional protective mechanisms against gut inflammation

    Article • The Journal of Nutritional Biochemistry, June 2013, Elsevier

    Dr Lijuan Yuan

  35. Dose Effects of LAB on Modulation of Rotavirus Vaccine Induced Immune Responses

    Article • January 2013, IntechOpen

    Dr Lijuan Yuan

  36. Lactobacillus rhamnosus GG down regulates autophagy in intestinal mononuclear cells to enhance effector T cell responses induced by rotavirus vaccine

    Article • Journal of Clinical & Cellular Immunology, January 2013, OMICS Publishing Group

    Dr Lijuan Yuan

  37. The synthetic futures of vesicular stomatitis virus

    Article • Trends in Biotechnology, October 2012, Elsevier

    Dr Lijuan Yuan

  38. CD4+ CD25− FoxP3+ regulatory cells are the predominant responding regulatory T cells after human rotavirus infection or vaccination in gnotobiotic pigs

    Article • Immunology, September 2012, Wiley

    Dr Lijuan Yuan

  39. Characterization of immune modulating functions of γδ T cell subsets in a gnotobiotic pig model of human rotavirus infection

    Article • Comparative Immunology Microbiology and Infectious Diseases, July 2012, Elsevier

    Dr Lijuan Yuan

  40. Lactobacillus acidophilus and Lactobacillus reuteri modulate cytokine responses in gnotobiotic pigs infected with human rotavirus

    Article • Beneficial Microbes, March 2012, De Gruyter

    Dr Lijuan Yuan

  41. High dose and low dose Lactobacillus acidophilus exerted differential immune modulating effects on T cell immune responses induced by an oral human rotavirus vaccine in gnotobiotic pigs

    Article • Vaccine, February 2012, Elsevier

    Dr Lijuan Yuan

  42. Development of γδ T cell subset responses in gnotobiotic pigs infected with human rotaviruses and colonized with probiotic lactobacilli

    Article • Veterinary Immunology and Immunopathology, June 2011, Elsevier

    Dr Lijuan Yuan

  43. Porcine Small Intestinal Epithelial Cell Line (IPEC-J2) of Rotavirus Infection As a New Model for the Study of Innate Immune Responses to Rotaviruses and Probiotics

    Article • Viral Immunology, April 2010, Mary Ann Liebert Inc

    Dr Lijuan Yuan

  44. An Oral versus Intranasal Prime/Boost Regimen Using Attenuated Human Rotavirus or VP2 and VP6 Virus-Like Particles with Immunostimulating Complexes Influences Protection and Antibody-Secreting Cell Responses to Rotavirus in a Neonatal Gnotobiotic Pig M...

    Article • Clinical and Vaccine Immunology, January 2010, ASM Journals

    Dr Lijuan Yuan

  45. Simian Rotaviruses Possess Divergent Gene Constellations That Originated from Interspecies Transmission and Reassortment

    Article • Journal of Virology, November 2009, ASM Journals

    Dr Lijuan Yuan

  46. Resistance to Rotavirus Infection in Adult Volunteers Challenged with a Virulent G1P1A[8] Virus Correlated with Serum Immunoglobulin G Antibodies to Homotypic Viral Proteins 7 and 4

    Article • The Journal of Infectious Diseases, November 2009, Oxford University Press (OUP)

    Dr Lijuan Yuan

  47. A longitudinal cohort study in calves evaluated for rotavirus infections from 1 to 12 months of age by sequential serological assays

    Article • Archives of Virology, April 2009, Springer Science + Business Media

    Dr Lijuan Yuan

  48. Toll-like receptor and innate cytokine responses induced by lactobacilli colonization and human rotavirus infection in gnotobiotic pigs

    Article • Veterinary Immunology and Immunopathology, February 2009, Elsevier

    Dr Lijuan Yuan

  49. Probiotic Lactobacillus acidophilus enhances the immunogenicity of an oral rotavirus vaccine in gnotobiotic pigs

    Article • Vaccine, July 2008, Elsevier

    Dr Lijuan Yuan

  50. Virus-specific intestinal IFN-γ producing T cell responses induced by human rotavirus infection and vaccines are correlated with protection against rotavirus diarrhea in gnotobiotic pigs

    Article • Vaccine, June 2008, Elsevier

    Dr Lijuan Yuan

  51. Influence of probiotic Lactobacilli colonization on neonatal B cell responses in a gnotobiotic pig model of human rotavirus infection and disease

    Article • Veterinary Immunology and Immunopathology, March 2008, Elsevier

    Dr Lijuan Yuan

  52. Lactic acid bacterial colonization and human rotavirus infection influence distribution and frequencies of monocytes/macrophages and dendritic cells in neonatal gnotobiotic pigs

    Article • Veterinary Immunology and Immunopathology, February 2008, Elsevier

    Dr Lijuan Yuan

  53. Transfer of maternal cytokines to suckling piglets: In vivo and in vitro models with implications for immunomodulation of neonatal immunity

    Article • Veterinary Immunology and Immunopathology, June 2007, Elsevier

    Dr Lijuan Yuan

  54. High Titers of Circulating Maternal Antibodies Suppress Effector and Memory B-Cell Responses Induced by an Attenuated Rotavirus Priming and Rotavirus-Like Particle-Immunostimulating Complex Boosting Vaccine Regimen

    Article • Clinical and Vaccine Immunology, April 2006, ASM Journals

    Dr Lijuan Yuan

  55. Low titer maternal antibodies can both enhance and suppress B cell responses to a combined live attenuated human rotavirus and VLP-ISCOM vaccine

    Article • Vaccine, March 2006, Elsevier

    Dr Lijuan Yuan

  56. Cytokine Responses in Gnotobiotic Pigs after Infection with Virulent or Attenuated Human Rotavirus

    Article • Journal of Virology, January 2006, ASM Journals

    Dr Lijuan Yuan

  57. Mucosal and systemic antibody responses and protection induced by a prime/boost rotavirus-DNA vaccine in a gnotobiotic pig model

    Article • Vaccine, June 2005, Elsevier

    Dr Lijuan Yuan

  58. Viremia and Nasal and Rectal Shedding of Rotavirus in Gnotobiotic Pigs Inoculated with Wa Human Rotavirus

    Article • Journal of Virology, May 2005, ASM Journals

    Dr Lijuan Yuan

  59. Mucosal Veterinary Vaccines: Comparative Vaccinology

    Article • January 2005, Elsevier

    Dr Lijuan Yuan

  60. Erratum to “Species-specific but not genotype-specific primary and secondary isotype-specific NSP4 antibody responses in gnotobiotic calves and piglets infected with homologous host bovine (NSP4[A]) or porcine (NSP4[B]) rotavirus ” [Virology 330 (2004)...

    Article • Virology, January 2005, Elsevier

    Dr Lijuan Yuan

  61. Species-specific but not genotype-specific primary and secondary isotype-specific NSP4 antibody responses in gnotobiotic calves and piglets infected with homologous host bovine (NSP4[A]) or porcine (NSP4[B]) rotavirus

    Article • Virology, December 2004, Elsevier

    Dr Lijuan Yuan

  62. Modulation by colostrum-acquired maternal antibodies of systemic and mucosal antibody responses to rotavirus in calves experimentally challenged with bovine rotavirus

    Article • Veterinary Immunology and Immunopathology, July 2004, Elsevier

    Dr Lijuan Yuan

  63. Homotypic and Heterotypic Serum Isotype–Specific Antibody Responses to Rotavirus Nonstructural Protein 4 and Viral Protein (VP) 4, VP6, and VP7 in Infants Who Received Selected Live Oral Rotavirus Vaccines

    Article • The Journal of Infectious Diseases, May 2004, Oxford University Press (OUP)

    Dr Lijuan Yuan

  64. Magnitude of Serum and Intestinal Antibody Responses Induced by Sequential Replicating and Nonreplicating Rotavirus Vaccines in Gnotobiotic Pigs and Correlation with Protection

    Article • Clinical and Diagnostic Laboratory Immunology, January 2004, ASM Journals

    Dr Lijuan Yuan

  65. Protection and antibody responses to oral priming by attenuated human rotavirus followed by oral boosting with 2/6-rotavirus-like particles with immunostimulating complexes in gnotobiotic pigs

    Article • Vaccine, September 2003, Elsevier

    Dr Lijuan Yuan

  66. II, 14. Rotavirus-like particle vaccines evaluated in a pig model of human rotavirus diarrhea and in cattle

    Article • January 2003, Elsevier

    Dr Lijuan Yuan

  67. Induction of mucosal immune responses and protection against enteric viruses: rotavirus infection of gnotobiotic pigs as a model

    Article • Veterinary Immunology and Immunopathology, September 2002, Elsevier

    Dr Lijuan Yuan

  68. Systemic and intestinal antibody secreting cell responses and protection in gnotobiotic pigs immunized orally with attenuated Wa human rotavirus and Wa 2/6-rotavirus-like-particles associated with immunostimulating complexes

    Article • Vaccine, March 2002, Elsevier

    Dr Lijuan Yuan

  69. Protective Immunity and Antibody-Secreting Cell Responses Elicited by Combined Oral Attenuated Wa Human Rotavirus and Intranasal Wa 2/6-VLPs with Mutant Escherichia coli Heat-Labile Toxin in Gnotobiotic Pigs

    Article • Journal of Virology, October 2001, ASM Journals

    Dr Lijuan Yuan

  70. Antibody-Secreting Cell Responses to Rotavirus Proteins in Gnotobiotic Pigs Inoculated with Attenuated or Virulent Human Rotavirus

    Article • Journal of Clinical Microbiology, August 2001, ASM Journals

    Dr Lijuan Yuan

  71. Short-term immunoglobulin A B-cell memory resides in intestinal lymphoid tissues but not in bone marrow of gnotobiotic pigs inoculated with Wa human rotavirus

    Article • Immunology, June 2001, Wiley

    Dr Lijuan Yuan

  72. Intranasal Administration of 2/6-Rotavirus-Like Particles with Mutant Escherichia coli Heat-Labile Toxin (LT-R192G) Induces Antibody-Secreting Cell Responses but Not Protective Immunity in Gnotobiotic Pigs

    Article • Journal of Virology, October 2000, ASM Journals

    Dr Lijuan Yuan

  73. Pathogenesis of an attenuated and a virulent strain of group A human rotavirus in neonatal gnotobiotic pigs

    Article • Journal of General Virology, July 1996, Society for General Microbiology

    Dr Lijuan Yuan