What is it about?
Reacting pyrazoles 2a-c with aromatic aldehydes and/or methyl glycinate produced Schiff's bases 7a-d and pyrazolo[3,4-b]-pyrazinone derivative 8, respectively. Treating 7 with ammonium acetate and/or hydrazine hydrate, furnished the imidazolopyrazole and pyrazolotriazine derivatives 9 and 10, respectively. Reaction of 8 with chloroacetic acid and/or diethyl malonate gave tricyclic compound 11 and triketone 12, respectively.
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Why is it important?
compound 1 was reacted with active methylene precursors, e.g., acetylacetone and/or cyclopentanone producing adducts 14a,b which upon fusion with ammonium acetate furnished the 3-pyridone derivatives 15a,b, respectively.
Perspectives
Some of newly synthesized compounds were screened for activity against bacterial and fungal strains and most of the newly synthesized compounds showed high antimicrobial activities
Professor Sameh Ahmed Rizk
ASU, Science, Chemistry
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This page is a summary of: Synthesis of Some Novel Heterocyclic and Schiff Base Derivatives as Antimicrobial Agents, Molecules, October 2015, MDPI AG,
DOI: 10.3390/molecules201018201.
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