What is it about?

Platelet activating factor (PAF) is a pro-inflammatory mediator produced by many cell types that activates not only platelets, but leukocytes and, among them, neutrophils. PAF triggers coagulation and inflammation, among other functions, and when its signaling is unregulated, it causes severe clinical conditions, as systemic inflammatory response and sepsis. In this study we detailed the molecular response of neutrophils to PAF by comparing the protein profiles of cells exposed or not to PAF. We found proteins that were not yet described in the neutrophil and found proteins presenting different abundances between the conditions. Such proteins indicate that PAF stimulation is related to increased DNA repair processes, calcium flux, protein transcription and cytoskeleton alterations that facilitate migration and degranulation, as well as the release of proteins that modulate the inflammatory response.

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Why is it important?

A better understanding of how PAF interferes with neutrophil signaling pathways will lead to new possible targets for preventing or treating the systemic inflammatory response syndrome and its consequences.

Perspectives

An article revealing proteins in the human neutrophil that are regulated by PAF stimulation. This article would be interesting for researchers working with inflammation, as it highlights pathways and provides new information on the response to the platelet aggregation factor. It is also of interest to the fields of cell motility and ROS production.

Professor Wagner Fontes
University of Brasilia

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This page is a summary of: Proteomic Analysis of Neutrophil Priming by PAF, Protein and Peptide Letters, January 2016, Bentham Science Publishers, DOI: 10.2174/0929866523666151202210604.
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