What is it about?
This study identifies and characterizes a protein fraction from Lupinus albus (white lupin) seeds that can inhibit two enzymes, MMP-2 and MMP-9. These enzymes play a key role in tissue damage, inflammation, and cancer spread. The researchers isolated the active proteins and tested them in both colon cancer cells and a mouse model of colitis. Results showed that the lupin proteins strongly reduced MMP activity without harming healthy cells, and oral administration eased colon inflammation and ulceration in mice. The proteins remained stable during digestion and were water-soluble, making them promising as food-based bioactives or nutraceuticals.
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Why is it important?
MMP-2 and MMP-9 are major therapeutic targets, but previous synthetic inhibitors often failed due to toxicity and side effects. Discovering a safe, edible, plant-derived protein inhibitor is a breakthrough. This work shows that lupin seeds, already part of Mediterranean diets, could provide a natural tool to help prevent or manage inflammatory bowel disease and reduce cancer risk. It positions lupin proteins as candidates for functional foods and nutraceuticals with real clinical potential.
Perspectives
What excites me about this research is how a traditional food like lupin reveals hidden potential as a therapeutic tool. The idea that proteins naturally present in seeds could block enzymes driving cancer and inflammation feels both innovative and accessible. To me, this study highlights the promise of re-examining familiar foods with modern science to uncover new strategies for disease prevention and health promotion.
Dr. Rosa Direito
Universidade de Lisboa
Read the Original
This page is a summary of: Lupinus albus Protein Components Inhibit MMP-2 and MMP-9 Gelatinolytic Activity In Vitro and In Vivo, International Journal of Molecular Sciences, December 2021, MDPI AG,
DOI: 10.3390/ijms222413286.
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