CD15s/CD62E Interaction Mediates the Adhesion of Non-Small Cell Lung Cancer Cells on Brain Endothelial Cells: Implications for Cerebral Metastasis

Samah Jassam, Zaynah Maherally, James Smith, Keyoumars Ashkan, Federico Roncaroli, Helen Fillmore, Geoffrey Pilkington
  • International Journal of Molecular Sciences, July 2017, MDPI AG
  • DOI: 10.3390/ijms18071474

Spread of lung cancer to the brain

Photo by Natanael Melchor on Unsplash

Photo by Natanael Melchor on Unsplash

What is it about?

The amount of a polysaccharide molecule CD15s that exists on the surfaces of cells is dramatically increased in lung (and brain) cancer cells. We have shown this molecule can bind to the protein CD62E found on the surfaces of healthy brain cells. The binding event therefore aids the spread of lung cancers to the brain, where their prognosis is much worse.

Why is it important?

This paper identifies a mechanism of the spread of lung cancer to the brain (metastasis) where the prognosis is much worse. The identification of a mechanism is a step towards finding a cure.


Dr James R Smith
University of Portsmouth

This paper is open access.

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The following have contributed to this page: Dr James R Smith