Unlocking the Health Benefits of Black Soldier Fly Larvae Proteins

What is it about?

The study explores the potential of black soldier fly larvae (BSFL) proteins to release health-promoting peptides after human gastrointestinal (GI) digestion. The study virtually proteolyzed 26 BSFL proteins with GI proteases and screened the resultant peptides for high GI absorption and non-toxicity. The shortlisted peptides were searched against the BIOPEP-UWM and Scopus databases to identify their bioactivities. The potential of the peptides as inhibitors of myeloperoxidase (MPO), NADPH oxidase (NOX), and xanthine oxidase (XO), as well as a disruptor of Keap1-Nrf2 protein-protein interaction, were predicted using molecular docking and dynamics simulation.

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Photo by oktavianus mulyadi on Unsplash

Photo by oktavianus mulyadi on Unsplash

Why is it important?

This study is important because it explores the potential health benefits of consuming black soldier fly larvae (BSFL) proteins. The research question addressed in this paper has not been explored before, and therefore provides new insights into whether BSFL can release peptides that have antioxidant, anti-ACE, or other bioactivities upon consumption by humans. This information could be useful for developing functional food ingredients with significant health benefits from BSFL proteins.