Peptides from Oilseeds as Alternatives to Antibiotics for Shrimp Disease Management

What is it about?

This research study investigates the use of peptides from oilseed meals as a potential substitute for antibiotics in managing Acute Hepatopancreatic Necrosis Disease (AHPND). An in silico analysis was conducted to identify 24 non-toxic, thermally stable, and low water soluble peptides that have the potential to bind with PirA vp/PirB vp toxins. Further screening revealed six dual-targeting peptides which could potentially intercept complex formation on both PirA vp and PirBvp. These findings provide a promising alternative approach for AHPND management without involving antibiotics.

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Photo by Máté Molnár on Unsplash

Photo by Máté Molnár on Unsplash

Why is it important?

AHPND is a severe disease which has had an enormous impact on the shrimp aquaculture industry. Overuse of antibiotics for managing AHPND can lead to antibiotic resistance, making it critical to search for alternatives. This research presents an alternative solution by exploring the use of peptides from oilseed meals as potential anti-AHPND agents without involving antibiotics, thus stopping Vibrio parahaemolyticus pathogenesis through intercepting PirAvp/PirBvp complex formation.