What is it about?

This is a review of recent work demonstrating the ability of exercise to regulate Marrow adipose tissue (fat inside bone).

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Why is it important?

The review highlights the first studies demonstrating exercise regulation of marrow adipose tissue. Investigators interested in osteoporosis and skeletal health have long noted an association between marrow adipose tissue and bone fragility. Nevertheless, the physiologic function of this fat depot remained unclear. This review summarizes work which begins to provide the field with a functional understanding of how this fat may serve as an energy store.


As more robust imaging and quantification tools emerge, conclusions can be made regarding marrow adipose tissue physiology and relationship to bone health. We have learned that marrow fat increases in obesity and with certain diabetes therapies and is significantly regulated with daily exercise.

Dr Maya Styner
University of North Carolina at Chapel Hill, Department of Medicine, Division of Endocrinology

Read the Original

This page is a summary of: Exercise Regulation of Marrow Adipose Tissue, Frontiers in Endocrinology, July 2016, Frontiers, DOI: 10.3389/fendo.2016.00094.
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