Expanding the Clinical Spectrum of IgLON5-Syndrome

What is it about?

IgLON5-Syndrome is a recently known antibody-mediated disease that was originally associated with sleep-related disturbancies and central symptom like parkinsonism, chorea and limb ataxia. We describe the first case of a patient with IgLON5-syndrome and generalized neuromyotonia, resembling a peripheral involvement in this previously described mainly central disease.

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Why is it important?

This case illustrates the expanding clinical spectrum of IgLON5-syndrome. Besides his central symptoms, this patient had signs for peripheral involvement with neuromyotonic discharges, muscle weakness and wasting, suggesting an affection of the second motor neuron or peripheral nerve.