Conflicting Factors in Shared Links between Alzheimer's Disease and Diabetes

What is it about?

The number of people getting Alzheimer's disease has been increasing a lot in recent years. This disease is expected to become even more common because of factors like people living longer and the potential effects of things like obesity and diabetes. Since there are only a few treatments to help with Alzheimer's symptoms right now, finding ways to prevent the disease is really important. Diabetes might be one factor that's connected to Alzheimer's. In our study, we looked into whether certain genes could be linked to both Alzheimer's and diabetes. And we found some genes that do play a role in both. But it's not as simple as just one gene affecting both diseases. Indeed, one gene, called Notch Receptor 2, seems to make the risk of both Alzheimer's and diabetes higher. However, the other genes from the apolipoprotein E gene cluster and human leukocyte antigen system make the risk of Alzheimer's higher but the risk of diabetes lower. These results help us understand more about the genes that affect Alzheimer's and diabetes, and how they're connected in different ways.

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