What is it about?
Overall pattern of antiepileptic drug use, as well as differences between single antiepileptic drug substances with adjustment on the incidence of epilepsy diagnosis in persons with Alzheimer's disease compared to matched persons without Alzheimer's disease. Large cohort register-based study of community-dwelling persons (n=70718) was utilized for this study.
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Why is it important?
Persons with Alzheimer disease used antiepileptic drugs more frequently than those without Alzheimer disease, and the majority of them used older generation of antiepileptics despite their possible adverse effects on cognition and high potential to drug-drug interactions.
Perspectives
The pathological changes in Alzheimer disease may increase the susceptibility to the adverse events of antiepileptic drugs, and careful clinical consideration is needed before prescribing them to a person with Alzheimer's disease.
Tatyana Sarycheva
University of Eastern Finland
Read the Original
This page is a summary of: Incidence and Prevalence of Antiepileptic Medication Use in Community-Dwelling Persons with and without Alzheimer’s Disease, Journal of Alzheimer s Disease, October 2018, IOS Press,
DOI: 10.3233/jad-180594.
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