What is it about?
Identification and description of plasma protein expressions that best classify subjects with cerebrospinal fluid-defined presence of AD pathology and cerebral amyloidosis.
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Why is it important?
Plasma proteins improved classification accuracy of Alzheimer disease in cognitively-impaired older adults and appeared representative of amyloid pathology.
Perspectives
The identified plasma proteins may serve to improve differential diagnosis in cognitively impaired older adults and to facilitate identification of subjects at risk that could benefit from prevention strategies or clinical trials focusing on amyloid pathology. Replication in an independent cohort will be needed before further translation to clinical use, but our findings may reveal valuable in the quest for a blood test for the diagnosis of Alzheimer disease pathology at early disease stages.
Loïc Dayon
Nestle SA
Read the Original
This page is a summary of: Plasma Proteomic Profiles of Cerebrospinal Fluid-Defined Alzheimer’s Disease Pathology in Older Adults, Journal of Alzheimer’s Disease, November 2017, IOS Press,
DOI: 10.3233/jad-170426.
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