What is it about?

Alzheimer’s disease is a devastating neurodegenerative disease and the most common form of dementia that currently affects 55 million people globally. Alzheimer’s disease is characterized by loss of memory, changes in mood and behavior and the inability to perform daily tasks. Besides its clinical symptoms, Alzheimer’s disease comprises enormous socioeconomic burdens as well as social and psychological difficulties for caretakers and families. Inflammation, a major hallmark of Alzheimer’s disease, has recently emerged as a potential therapeutic target. In this study we show that targeting TNF-α, a master regulator of the immune system, and its receptors, results in improvements in cognitive functions and attenuation of Alzheimer-related neuropathology in a mouse model of Alzheimer’s disease.

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Why is it important?

Despite decades of exhaustive research, no successful treatment has been discovered for Alzheimer’s disease. Therefore, there is an increasing urgent need to develop effective therapies for the treatment of Alzheimer’s disease and other neurodegenerative diseases. Our main finding indicates that systemically modulating the immune system via TNF-receptor signaling may be used as a therapeutic strategy for the treatment of Alzheimer’s disease.


This publication suggests that systemically modulating the immune system using a TNF receptor 2 agonist is a promising approach for the treatment of Alzheimer’s disease. We observed that our treatment approach improved cognitive functions and attenuated the brain pathology associated to Alzheimer’s disease. Even though further research is necessary, this study has provided a more in depth understanding on the role, mechanisms and effects of modulating the immune system in Alzheimer’s disease and proposed new potential therapeutic strategies that can be explored in the future for the treatment of Alzheimer’s disease.

Natalia Ortí Casañ
Rijksuniversiteit Groningen

Read the Original

This page is a summary of: Activation of TNF Receptor 2 Improves Synaptic Plasticity and Enhances Amyloid-β Clearance in an Alzheimer’s Disease Mouse Model with Humanized TNF Receptor 2, Journal of Alzheimer s Disease, August 2023, IOS Press, DOI: 10.3233/jad-221230.
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