What is it about?

the link between the amyloid beta 1-42 , iron dysmetabolism in the blood stream , cognitive decline and the onset of Alzheimer's disease . Does amyloid beta 1-42 has a protective or instigator role ?

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Why is it important?

This is an interesting paper showing changes in levels of iron and iron-related proteins in CSF and plasma of AD patients vs controls. We think It is an important contribution to the field

Perspectives

Our findings indicate that the components of iron metabolism in the bloodstream influence the pathophysiological processes of AD and are potential therapeutic targets. In addition, the measurement of iron’s metabolism, regulation, and transporters in the bloodstream could be useful additions to existing biomarker panels in disease diagnosis.

najla jouini
Institute of Technology Tralee

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This page is a summary of: Impacts of Iron Metabolism Dysregulation on Alzheimer’s Disease, Journal of Alzheimer s Disease, April 2021, IOS Press, DOI: 10.3233/jad-201250.
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