What is it about?

Soluble assemblies of amyloid-β protein (Aβ) called Aβ oligomers play a significant role in the pathological mechanism of Alzheimer’s disease (AD). We have discovered that a natural compound, tyrosol can inhibit the neurotoxicity of Aβ oligomers in neuronal cultures and effectively suppress synaptic and oxidative disturbances and mitigate cognitive impairment in the mouse model of AD. We propose that this compound is a drug candidate which can be helpful for the treatment and prevention of AD-associated cognitive disturbance.

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Why is it important?

This study suggests a novel strategy against the AD-associated cognitive disturbance through the reduction of Aβ oligomers neurotoxicity by a natural compound.

Perspectives

We propose a new approach for the early intervention at the stage of mild cognitive impairment due to AD. We are currently seeking to proceed to the drug development step.

Dr. Wataru Araki
National Center of Neurology and Psychiatry

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This page is a summary of: Tyrosol Reduces Amyloid-β Oligomer Neurotoxicity and Alleviates Synaptic, Oxidative, and Cognitive Disturbances in Alzheimer’s Disease Model Mice, Journal of Alzheimer s Disease, August 2019, IOS Press, DOI: 10.3233/jad-190098.
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