What is it about?
The study shows that there is an underlying epidemiological structure of several neurodegenerative diseases and that the misfolded protein deposit may explain it.
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Why is it important?
Because it links risk factor epidemiology (general) with biomarkers epidemiology (clinical) and because shows that there could be shared modifiers of risk or disease course (progression). Identification of molrcules or drugs which might act across diseases may arise from such deductive idea. The driver notion opens a research field aimed to validate it and may uncover keys to understand results of epidemiological studies for single disorders.
Perspectives
International collaboration either with clinical preventive attitude or with public health perspective is essential. Use of already registered data may provide results rapidly. Scientists most appropriate for benefits are those with deep knowledge of epidemiology or models for single diseases. Isolated work on single disorders can be renewed and reinteroreted from thie drivers view,
Jesús de Pedro-Cuesta
Read the Original
This page is a summary of: Drivers: A Biologically Contextualized, Cross-Inferential View of the Epidemiology of Neurodegenerative Disorders, Journal of Alzheimer s Disease, April 2016, IOS Press,
DOI: 10.3233/jad-150884.
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Contributors
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