What is it about?

This study examined the relationship between body mass index and cognitive function, as well as Alzheimer's disease (AD) biomarkers, in the elderly with different cognitive status. Additionally, the influence of APOE ε4 status and Aβ status on this association was also investigated. This study also provided some information regarding AD screening.

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Why is it important?

AD is the leading cause of dementia, and BMI is a well-known modifiable factor for AD. The relationship between the two is not yet fully understood. Further investigating their association can help in implementing appropriate disease prevention strategies and also contribute to a deeper understanding of the mechanisms underlying AD.


In individuals with normal cognition, it is important to maintain a normal BMI range. For individuals with cognitive impairment, particularly those who are APOE ε4 carriers or Aβ-positive status, monitoring BMI and avoiding excessively low levels is recommended. Additionally, in individuals with cognitive impairment, higher diastolic blood pressure is associated with higher hippocampal volume and better cognitive performance.

Qin Li
Chongqing Medical University

Read the Original

This page is a summary of: The Association of Body Mass Index with Cognition and Alzheimer’s Disease Biomarkers in the Elderly with Different Cognitive Status: A Study from the Alzheimer’s Disease Neuroimaging Initiative Database, Journal of Alzheimer s Disease Reports, January 2024, IOS Press,
DOI: 10.3233/adr-230163.
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