Towards understanding mechanisms governing cytotoxicity of metal oxides nanoparticles: Hints from nano-QSAR studies

Agnieszka Gajewicz, Nicole Schaeublin, Bakhtiyor Rasulev, Saber Hussain, Danuta Leszczynska, Tomasz Puzyn, Jerzy Leszczynski
  • Nanotoxicology, July 2014, Taylor & Francis
  • DOI: 10.3109/17435390.2014.930195

Cytotoxicity Mechanisms of metal oxides nanoparticles: Nano-QSAR studies

What is it about?

We proposed two types of mechanisms of toxic action supported by the nano-QSAR model, which collectively govern the toxicity of the metal oxide nanoparticles. The combined experimental-theoretical study allowed us to develop an interpretative nano-QSAR model describing toxicity of 18 nano-metal oxides to a HaCaT cell line as a model for dermal exposure. In result, by the comparison of the toxicity of metal oxide nanoparticles to bacteria Escherichia coli (prokaryotic system) and a human keratinocyte cell line (eukaryotic system), we hypothesized different modes of toxic action occur between prokaryotic and eukaryotic systems.

Why is it important?

A first time was offered a hypothesis for different modes of toxic action that occur between prokaryotic and eukaryotic systems.

Perspectives

Professor Bakhtiyor Rasulev
North Dakota State University

A new hypothesis for metal oxide nanoparticles toxicity was proposed.

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http://dx.doi.org/10.3109/17435390.2014.930195

The following have contributed to this page: Professor Jerzy Leszczynski and Professor Bakhtiyor Rasulev